C. Wyatt Shields IV

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Charles (Wyatt) Shields IV is an Associate Professor at the University of Colorado Boulder in the Department of Biological engineering and Chemical engineering.[1] His research involves the rational design of Colloid and supracolloidal particles for applications in drug delivery and biosensing.[2]

Education

C. Wyatt Shields IV attended the University of Virginia and received a Bachelor of Science with High Distinction in Biomedical Engineering in 2011, performing undergraduate research with Dr. Jeffrey Saucerman and Dr. William Walker.[3] He continued his career in research as a graduate student in Biomedical Engineering at Duke University for Dr. Gabriel López and obtained his PhD in 2016. During his PhD, Wyatt Shields studied magnetic and accoustic methods for isolation and analysis of cells.[4]

Career

Wyatt Shields performed postdoctoral research at North Carolina State University working with Dr. Orlin D. Velev and Dr. Stefan Zauscher in 2017[5] and at Harvard University with Dr. Samir Mitragotri in 2018. At Harvard's Wyss Institute for Biologically Inspired Engineering, Shields developed cytokine-releasing macrophage "backpacks" that maintain a tumor-killing state in cells, travel to tumor sites, and slow their growth.[6][7][8]

Wyatt Shields became an Assistant Professor at the University of Colorado Boulder in 2020 in Biological and Chemical Engineering.[8] He is also an Affiliate Professor in the Biomedical Engineering Program and in the Materials Science and Engineering Program. Working at the intersection of materials, soft matter physics, and bioengineering, Shields focuses on understanding how stimuli-responsive particles behave in physiological settings and controlling their assembly and motion for biological applications.[1] His lab has numerous clinical collaborations.[9] Current research includes investigating the role of immune cells in decompression sickness using lung-on-a-chip devices,[10][11] developing "bottom-up" multifunctional magnetic microrobots,[12][13] and using accoustically responsive particles for capture and purification of disease biomarkers.[14]

Shields' early career has been highly successful, with numerous high profile awards, 5 patents filed,[15] and over 40 articles published in journals such as Science Advances,[16][17] Advanced Materials,[18] Advanced Functional Materials,[19] and Journal of Controlled Release.[20] Additionally, he is a Guest Associate Editor for the journal Bioengineering & Translational Medicine.

Another hallmark of Shields' career is his commitment to scientific outreach and mentorship. For several years, his group has worked with a local high school to provide engineering problems related to the lab's work in drug delivery and biosensing, giving students the opportunity to design prototypes and work on real life engineering problems.[21] Shields also was recognized for his mentorship of students of diverse and underrepresented backgrounds in 2016 while working under Dr. Gabriel López.[22]

Awards and Honors

In his third year at the University of Colorado Boulder, Shields received five distinguished research awards, including a National Science Foundation (NSF) CAREER award,[21][23][24] Office of Naval Research (ONR) Young Investigator Program award,[25] Pew Biomedical Scholars award,[26][27] David and Lucile Packard Foundation,[13] and an National Institutes of Health National Institute of General Medical Sciences (NIGMS) Maximizing Investigators' Research Award (MIRA).[13] Shields is one of only 20 recipients of the prestigious Packard Fellowship at the University of Colorado Boulder.[28]

Other awards and honors include:

  • CU Boulder Lab Venture Challenge Awardee (2022) [29]
  • Outreach Partner of the Year, Northglenn High School (2022)
  • Beckman Young Investigators Award Finalist (2022)
  • NIH Exploratory/Developmental Research Grant Award (2021)[14]
  • Best On-Demand Talk by the Controlled Release Society (2020)
  • Dean’s Award for Excellence in Mentoring, Duke University (2016)[22]
  • NSF Graduate Research Fellowship (2012)[30]
  • NSF Research Triangle MRSEC Fellowship (2011) [22]

References

  1. ↑ 1.0 1.1 "C. Wyatt Shields IV". Chemical and Biological Engineering. 2018-09-19. Retrieved 2022-12-03.
  2. ↑ "Home | Shields Lab". www.colorado.edu. Retrieved 2022-12-03.
  3. ↑ Han, Koohee; Shields, C. Wyatt; Velev, Orlin D. (18 December 2017). "Engineering of Self‐Propelling Microbots and Microdevices Powered by Magnetic and Electric Fields". Advanced Functional Materials. 28 (25): 1705953. doi:10.1002/adfm.201705953. ISSN 1616-301X. S2CID 103633421.
  4. ↑ Iv, Shields; Wyatt, Charles (2016). "Acoustic and Magnetic Techniques for the Isolation and Analysis of Cells in Microfluidic Platforms". {{cite journal}}: Cite journal requires |journal= (help)
  5. ↑ University, North Carolina State. "Microbot origami can capture, transport single cells". phys.org. Retrieved 2022-12-04.
  6. ↑ Ktori, Sophia (2020-04-30). "Cytokine "Backpacks" Keep Macrophages in Cancer-Killing State". GEN - Genetic Engineering and Biotechnology News. Retrieved 2022-12-04.
  7. ↑ "Researchers Develop Macrophage 'Backpacks' to Combat Tumors in Mice". BioSpace. Retrieved 2022-12-04.
  8. ↑ 8.0 8.1 ""Backpacks" boost immune cells' ability to kill cancer". seas.harvard.edu. Retrieved 2022-12-04.
  9. ↑ "New collaborative grants advance innovative interdisciplinary research to improve human health and well-being". Research & Innovation Office. 2022-06-02. Retrieved 2022-12-04.
  10. ↑ Group, SAE Media. "University of Colorado Boulder". www.techbriefs.com. Retrieved 2022-12-04.
  11. ↑ "Fighting "the bends": Shields receives Office of Naval Research Young Investigator Program Award for decompression sickness study". Chemical and Biological Engineering. 2022-03-07. Retrieved 2022-12-04.
  12. ↑ packardwpadmin (2022-10-18). "Meet the 2022 Class of Packard Fellows for Science and Engineering". The David and Lucile Packard Foundation. Retrieved 2022-12-04.
  13. ↑ 13.0 13.1 13.2 "CU Boulder's Wyatt Shields wins 2022 Packard Fellowship for microscale robotics". Chemical and Biological Engineering. 2022-10-19. Retrieved 2022-12-04.
  14. ↑ 14.0 14.1 "Shields Lab receives NIH grant to help quickly diagnose fungal infections". Chemical and Biological Engineering. 2021-05-18. Retrieved 2022-12-04.
  15. ↑ "C. Wyatt Shields IV". scholar.google.com. Retrieved 2022-12-04.
  16. ↑ Shields, C. Wyatt; Evans, Michael A.; Wang, Lily Li-Wen; Baugh, Neil; Iyer, Siddharth; Wu, Debra; Zhao, Zongmin; Pusuluri, Anusha; Ukidve, Anvay; Pan, Daniel C.; Mitragotri, Samir (29 Apr 2020). "Cellular backpacks for macrophage immunotherapy". Science Advances. 6 (18): eaaz6579. Bibcode:2020SciA....6.6579S. doi:10.1126/sciadv.aaz6579. ISSN 2375-2548. PMC 7190308. PMID 32494680.
  17. ↑ Han, Koohee; Shields, C. Wyatt; Diwakar, Nidhi M.; Bharti, Bhuvnesh; López, Gabriel P.; Velev, Orlin D. (2017-08-04). "Sequence-encoded colloidal origami and microbot assemblies from patchy magnetic cubes". Science Advances. 3 (8): e1701108. Bibcode:2017SciA....3E1108H. doi:10.1126/sciadv.1701108. ISSN 2375-2548. PMC 5544397. PMID 28798960.
  18. ↑ Shields, C. Wyatt; Wang, Lily Li‐Wen; Evans, Michael A.; Mitragotri, Samir (28 June 2019). "Materials for Immunotherapy". Advanced Materials. 32 (13): 1901633. doi:10.1002/adma.201901633. ISSN 0935-9648. PMID 31250498. S2CID 195765229.
  19. ↑ Shields, Charles Wyatt; Han, Koohee; Ma, Fuduo; Miloh, Touvia; Yossifon, Gilad; Velev, Orlin D. (5 July 2018). "Supercolloidal Spinners: Complex Active Particles for Electrically Powered and Switchable Rotation". Advanced Functional Materials. 28 (35): 1803465. doi:10.1002/adfm.201803465. ISSN 1616-301X. S2CID 103270967.
  20. ↑ Shields, C. Wyatt; White, John P.; Osta, Erica G.; Patel, Jerishma; Rajkumar, Shashank; Kirby, Nickolas; Therrien, Jean-Philippe; Zauscher, Stefan (2018-05-28). "Encapsulation and controlled release of retinol from silicone particles for topical delivery". Journal of Controlled Release. 278: 37–48. doi:10.1016/j.jconrel.2018.03.023. ISSN 0168-3659. PMID 29604311. S2CID 4792307.
  21. ↑ 21.0 21.1 "Shields earns NSF CAREER Award for biomarkers research tied to high school outreach". Chemical and Biological Engineering. 2022-03-01. Retrieved 2022-12-04.
  22. ↑ 22.0 22.1 22.2 School, The Graduate. "C. Wyatt Shields IV, 2016 Dean's Award Winner". gradschool.duke.edu. Retrieved 2022-12-04.
  23. ↑ "NSF Award Search: Award # 2143419 - CAREER: Shape-Encoded Electrokinetic Particles for Multiplexed Biosensing". www.nsf.gov. Retrieved 2022-12-04.
  24. ↑ "College of engineering celebrates 6 NSF CAREER award winners in 2022". College of Engineering & Applied Science. 2022-06-26. Retrieved 2022-12-04.
  25. ↑ "2022 Young Investigator Award Recipients". Office of Naval Research. Retrieved 2022-12-04.{{cite web}}: CS1 maint: url-status (link)
  26. ↑ "C. Wyatt Shields IV, Ph.D." pew.org. Retrieved 2022-12-04.
  27. ↑ "Wyatt Shields named Pew Scholar in Biomedical Sciences". College of Engineering & Applied Science. 2022-06-13. Retrieved 2022-12-04.
  28. ↑ "Fellowship Directory". The David and Lucile Packard Foundation. Retrieved 2022-12-04.
  29. ↑ "CU Boulder innovators awarded $1.25 million in commercialization funding". Venture Partners at CU Boulder. 2022-11-09. Retrieved 2022-12-04.
  30. ↑ "NSF Graduate Research Fellowship and Major External Fellowship Recipients". Duke Pratt School of Engineering. 2016-10-31. Retrieved 2022-12-04.

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