Wolfgang M. Kuebler

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Wolfgang Michael Kuebler (* July 19, 1967 in Cologne) is a German-Canadian physiologist and Director of the Institute of Physiology at the Charité-Universitätsmedizin Berlin.[1]

Life

Kuebler studied medicine at the Ludwig Maximilian University of Munich (1987 - 1994) and received his doctorate summa cum laude in 1997 at the Institute of Surgical Research for his thesis on "Leukocyte kinetics in the pulmonary microcirculation". After a postdoctoral period at Columbia University New York with a fellowship of the German Research Foundation (DFG), he completed his habilitation for experimental surgery in 2001 at the Ludwig Maximilian University Munich. In 2002, he accepted an appointment to an endowed Associate Professorship of the Deutsches Herzzentrum Berlin at the Institute of Physiology of the Free University of Berlin, which became part of the Charité Berlin in 2003. In 2008, he moved to St. Michael's Hospital (Toronto) in Toronto, where he holds a Full Professorship in the Departments of Surgery and Physiology at the University of Toronto since 2015.[2] In 2016, he succeeded Axel Radlach Pries as Director of the Institute of Physiology at the Charité-Universitätsmedizin Berlin.[3]

Wolfgang M. Kuebler is the son of the cardiologist Wolfgang E. Kuebler. Wolfgang M. Kuebler is married and has two children.

Work

Kuebler's scientific work focuses on the physiology and pathophysiology of the pulmonary circulation. Particular foci of his research, which comprises almost 300 peer-reviewed articles in international journals, are the (patho-)mechanisms of hypoxic pulmonary vasoconstriction, endothelial barrier failure in ARDS and pneumonia, and vascular remodeling in pulmonary hypertension. Other areas of Kuebler's research work address the dynamics of inflammatory cells in the lung, alveolar dynamics during mechanical ventilation, the regulation of fluid homeostasis in the lung by epithelial ion channels and the development of pulmonary edema, and near-infrared spectroscopy.

Awards (selection)

  • 1999: Hermann Rein Award of the German Society for Microcirculation and Vascular Biology e. V. [4]
  • 2000: Lafon Award of the European Society for Microcirculation[5]
  • 2016: Arthur Weber Award "Research to help" of the Deutsche Gesellschaft für Kardiologie|German Cardiac Society[6]
  • 2016: Appointed a Member of the College of the Royal Society of Canada[7]
  • 2019: Fellow of the European Respiratory Society (FERS)[8]
  • 2019: Fellow of the American Physiological Society (FAPS)[9]

Activity in committees, professional societies and journals

At the American Physiological Society, Kuebler has served as Chair of the Respiratory Section (2011-2014), the Strategic Advisory Committee (2014-2017), and the Publications Committee (2023-present)[10]. For the German Society for Microcirculation and Vascular Biology e.V., he chaired the 2004 and 2022 annual meetings as President. Since 2014, Kuebler is Associate Editor of the American Journal of Physiology - Lung Cellular and Molecular Physiology [11] and since 2017 Associate Editor of the European Respiratory Journal [12]. He is a member of the editorial board of various other journals. He is an Associate Principal Investigator at the German Center for Lung Research (DZL) and the German Center for Cardiovascular Research (DZHK). Since 2019, Kuebler serves as Vice Chair of the Faculty Board at the Charité-Universitätsmedizin Berlin.

Publications (selection)

  1. L. Erfinanda, L. Zou, B. Gutbier, L. Kneller, S. Weidenfeld, L. Michalick, D. Lei, K. Reppe, L.G. Teixeira Alves, B. Schneider, Q. Zhang, C. Li, D. Fatykhova, P. Schneider, W. Liedtke, E. Sohara, T.J. Mitchell, A. Grube, A. Hocke, S. Hippenstiel, N. Suttorp, A. Oleschewski, M.A. Mall, M. Witzenrath, W.M. Kuebler: Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation. Sci Transl Med 14: eabg8577, 2022.[13]
  2. T. Jiang, R. Samapati, S. Klassen, D. Lei, V. Jankowski, S. Simmons, J. Yin, C. Arenz, A. Dietrich, T. Gudermann, D. Adam, M. Schaefer, J. Jankowski, V. Flockerzi, R. Nüsing, S. Uhlig, W.M. Kuebler: Stimulation of the EP3 receptor causes lung edema by activation of TRPC6 in pulmonary endothelial cells. Eur Respir J 60: 2102635, 2022.[14]
  3. M.J. McVey, M. Maishan, C. Spring, M. Kim, A. Tabuchi, V. Srbely, A. Takabe-French, C. Arenz, J.W. Semple, W.M. Kuebler: Platelet-derived extracellular vesicles mediate transfusion-related acute lung injury by imbalancing the bioactive sphingolipid rheostat. Blood 137: 690-701, 2021.[15]
  4. L. Erfinanda, K. Ravindran, F. Kohse, K. Gallo, R. Preissner, T. Walther, W.M. Kuebler: Estrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation. Eur Respir J 57: 2000921, 2021.[16]
  5. Y. Fan, X. Gu, J. Zhang, K. Sinn, W. Klepetko, N. Wu, V. Foris, P. Solymosi, G. Kwapiszewska, W.M. Kuebler: TWIST1 Drives Smooth Muscle Cell Proliferation in Pulmonary Hypertension via Loss of GATA-6 and BMPR2. Am J Respir Crit Care Med 202: 1283-1296, 2020.[17]
  6. D. Zabini, E. Granton, Y. Hu, M.Z. Miranda, U. Weichelt, S. Breuils Bonnet, S. Bonnet, N. Morrell, K. Connelly, S. Provencher, B. Ghanim, W. Klepetko, A. Olschewski, A. Kapus, W.M. Kuebler: Loss of SMAD3 promotes vascular remodeling in pulmonary arterial hypertension via MRTF disinhibition. Am J Respir Crit Care Med 197: 244-260, 2018.[18]
  7. A. Tabuchi, H.T. Nickles, M. Kim, J.W. Semple, E. Koch, L. Brochard, A.S. Slutsky, A.R. Pries, W.M. Kuebler: Acute lung injury causes asynchronous alveolar ventilation which can be corrected by individual sighs. Am J Respir Crit Care Med 193: 396-406, 2016.[19]
  8. C. Tabeling, H. Yu, L. Wang, H. Ranke, N. Goldenberg, D. Zabini, E. Noe, A. Krauszman, B. Gutbier, J. Yin, M. Schaefer, C. Arenz, A. Hocke, N. Suttorp, R.L. Proia, M. Witzenrath, W.M. Kuebler: Cystic fibrosis transmembrane conductance regulator and sphingolipids mediate hypoxic pulmonary vasoconstriction through transient receptor potential canonical 6. Proc Natl Acad Sci USA 112: E1614-E1623, 2015.[20]
  9. A. Tabuchi, B. Styp-Rekowska, A.S. Slutsky, P.D. Wagner, A.R. Pries*, W.M. Kuebler*: Pre-capillary oxygenation contributes relevantly to gas exchange in the intact lung. Am J Respir Crit Care Med 188: 474-481, 2013.[21]
  10. E.A. Solymosi, S.M. Gembardt, I. Vadász, L. Wang, N. Neye, C. Chupin, S. Rozowsky, R. Ruehl, A. Tabuchi, Holger Schulz, A. Kapus, R.E. Morty, W.M. Kuebler: Chloride-transport driven alveolar fluid secretion as a novel mechanism in cardiogenic lung edema. Proc Natl Acad Sci USA 110: E2308-E2316, 2013.[22]
  11. L. Wang, J. Yin, H.T. Nickles, H. Ranke, A. Tabuchi, J. Hoffmann, C. Tabeling, E. Barbosa-Sicard, M. Chanson, B.R. Kwak, H.S. Shin, S. Wu, B.E. Isakson, M. Witzenrath, C. de Wit, I. Fleming, H. Kuppe, W.M. Kuebler: Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction. J Clin Invest 122: 4218-4230, 2012.[23]

References

  1. ↑ Hoffmann, Björn. "Institute of Physiology". Institute of Physiology. Retrieved 2023-02-07.
  2. ↑ "Wolfgang Kuebler | Research at St. Michael's Hospital". research.unityhealth.to. Retrieved 2023-02-07.
  3. ↑ CV. In: https://journals.physiology.org/ajplung/edboard The American Physiological Society. 2023-02-14 (see section "associate editors")
  4. ↑ Ärzteblatt, Deutscher Ärzteverlag GmbH, Redaktion Deutsches (2000-03-31). "Verleihungen". Deutsches Ärzteblatt (in Deutsch). Retrieved 2023-02-07.{{cite web}}: CS1 maint: multiple names: authors list (link)
  5. ↑ Lafon Microcirculation Award for Outstanding Publications 2000 https://www.karger.com/Article/Pdf/48999
  6. ↑ "Arthur-Weber Preis" (in Deutsch). Retrieved 2023-02-07.
  7. ↑ "Member Directory | The Royal Society of Canada". rsc-src.ca. Retrieved 2023-02-07.
  8. ↑ "Awards and Fellows". ERS - European Respiratory Society. Retrieved 2023-02-07.
  9. ↑ "FAPS Awardees". Default. Retrieved 2023-02-07.
  10. ↑ "Publications Committee". Default. Retrieved 2023-02-07.
  11. ↑ Associate Editors. In: https://journals.physiology.org/ajplung/edboard The American Physiological Society. 2023-02-14 (see section "associate editors")
  12. ↑ "Editorial Board | European Respiratory Society". erj.ersjournals.com. Retrieved 2023-02-14.
  13. ↑ Erfinanda, Lasti; Zou, Lin; Gutbier, Birgitt; Kneller, Laura; Weidenfeld, Sarah; Michalick, Laura; Lei, Disi; Reppe, Katrin; Teixeira Alves, Luiz Gustavo; Schneider, Bill; Zhang, Qi; Li, Caihong; Fatykhova, Diana; Schneider, Paul; Liedtke, Wolfgang (2022-12-07). "Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation". Science Translational Medicine. 14 (674): eabg8577. doi:10.1126/scitranslmed.abg8577. ISSN 1946-6242. PMID 36475904.
  14. ↑ Jiang, Tian; Samapati, Rudi; Klassen, Sergej; Lei, Disi; Erfinanda, Lasti; Jankowski, Vera; Simmons, Szandor; Yin, Jun; Arenz, Christoph; Dietrich, Alexander; Gudermann, Thomas; Adam, Dieter; Schaefer, Michael; Jankowski, Joachim; Flockerzi, Veit (2022-10-01). "Stimulation of the EP3 receptor causes lung oedema by activation of TRPC6 in pulmonary endothelial cells". European Respiratory Journal. 60 (4). doi:10.1183/13993003.02635-2021. ISSN 0903-1936. PMID 35450969.
  15. ↑ McVey, Mark J.; Weidenfeld, Sarah; Maishan, Mazharul; Spring, Chris; Kim, Michael; Tabuchi, Arata; Srbely, Victoria; Takabe-French, Alisa; Simmons, Szandor; Arenz, Christoph; Semple, John W.; Kuebler, Wolfgang M. (2021-02-04). "Platelet extracellular vesicles mediate transfusion-related acute lung injury by imbalancing the sphingolipid rheostat". Blood. 137 (5): 690–701. doi:10.1182/blood.2020005985. ISSN 0006-4971.
  16. ↑ Erfinanda, Lasti; Ravindran, Krishnan; Kohse, Franziska; Gallo, Kathleen; Preissner, Robert; Walther, Thomas; Kuebler, Wolfgang M. (2020-08-06). "Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation". European Respiratory Journal. 57 (1): 2000921. doi:10.1183/13993003.00921-2020. ISSN 0903-1936.
  17. ↑ Fan, Ye; Gu, Xia; Zhang, Jing; Sinn, Katharina; Klepetko, Walter; Wu, Na; Foris, Vasile; Solymosi, Philip; Kwapiszewska, Grazyna; Kuebler, Wolfgang M. (2020-11-01). "TWIST1 Drives Smooth Muscle Cell Proliferation in Pulmonary Hypertension via Loss of GATA-6 and BMPR2". American Journal of Respiratory and Critical Care Medicine. 202 (9): 1283–1296. doi:10.1164/rccm.201909-1884OC. ISSN 1535-4970. PMID 32692930.
  18. ↑ Zabini, Diana; Granton, Elise; Hu, Yijie; Miranda, Maria Zena; Weichelt, Ulrike; Breuils Bonnet, Sandra; Bonnet, Sébastien; Morrell, Nicholas W.; Connelly, Kim A.; Provencher, Steeve; Ghanim, Bahil; Klepetko, Walter; Olschewski, Andrea; Kapus, Andras; Kuebler, Wolfgang M. (2018-01-15). "Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition". American Journal of Respiratory and Critical Care Medicine. 197 (2): 244–260. doi:10.1164/rccm.201702-0386OC. ISSN 1535-4970. PMID 29095649.
  19. ↑ Tabuchi, Arata; Nickles, Hannah T.; Kim, Michael; Semple, John W.; Koch, Edmund; Brochard, Laurent; Slutsky, Arthur S.; Pries, Axel R.; Kuebler, Wolfgang M. (2016-02-15). "Acute Lung Injury Causes Asynchronous Alveolar Ventilation That Can Be Corrected by Individual Sighs". American Journal of Respiratory and Critical Care Medicine. 193 (4): 396–406. doi:10.1164/rccm.201505-0901OC. ISSN 1535-4970. PMID 26513710.
  20. ↑ Tabeling, Christoph; Yu, Hanpo; Wang, Liming; Ranke, Hannes; Goldenberg, Neil M.; Zabini, Diana; Noe, Elena; Krauszman, Adrienn; Gutbier, Birgitt; Yin, Jun; Schaefer, Michael; Arenz, Christoph; Hocke, Andreas C.; Suttorp, Norbert; Proia, Richard L. (2015-09-01). "Cystic fibrosis transmembrane conductance regulator and sphingolipids regulate hypoxic pulmonary vasoconstriction". European Respiratory Journal. 46 (suppl 59). doi:10.1183/13993003.congress-2015.PA4905. ISSN 0903-1936.
  21. ↑ Tabuchi, Arata; Styp-Rekowska, Beata; Slutsky, Arthur S.; Wagner, Peter D.; Pries, Axel R.; Kuebler, Wolfgang M. (2013-08-15). "Precapillary oxygenation contributes relevantly to gas exchange in the intact lung". American Journal of Respiratory and Critical Care Medicine. 188 (4): 474–481. doi:10.1164/rccm.201212-2177OC. ISSN 1535-4970. PMID 23796161.
  22. ↑ Ea, Solymosi; Sm, Kaestle-Gembardt; I, Vadász; L, Wang; N, Neye; Cj, Chupin; S, Rozowsky; R, Ruehl; A, Tabuchi; H, Schulz; A, Kapus; Re, Morty; Wm, Kuebler (2013-06-18). "Chloride transport-driven alveolar fluid secretion is a major contributor to cardiogenic lung edema". Proceedings of the National Academy of Sciences of the United States of America. 110 (25). doi:10.1073/pnas.1216382110. ISSN 1091-6490. PMID 23645634.
  23. ↑ Wang, Liming; Yin, Jun; Nickles, Hannah T.; Ranke, Hannes; Tabuchi, Arata; Hoffmann, Julia; Tabeling, Christoph; Barbosa-Sicard, Eduardo; Chanson, Marc; Kwak, Brenda R.; Shin, Hee-Sup; Wu, Songwei; Isakson, Brant E.; Witzenrath, Martin; de Wit, Cor (November 2012). "Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction". The Journal of Clinical Investigation. 122 (11): 4218–4230. doi:10.1172/JCI59176. ISSN 1558-8238. PMC 3484430. PMID 23093775.

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