Se-Jin Lee

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Se-Jin Lee
Born(1958-10-20)October 20, 1958
Alma materHarvard University
Known formechanisms of controlled muscle hypertrophy utilizing myostatin
Spouse(s)Emily Lucy Germain-Lee
ChildrenBenjamin Charles Germain Lee
AwardsRolf Luft Award
Scientific career
FieldsCell biology
Myostatin
ActivinA
Muscle hypertrophy
InstitutionsAmerican Academy of Arts & Sciences
National Academy of Sciences
National Academy of Inventors

Se-Jin Lee (October 20, 1958 ) is an American biologist and professor at the University of Connecticut and at the Jackson Laboratory.

His work has had wide impact in the understanding as to how skeletal muscle mass is controlled. He discovered several proteins in the large "TGFbeta" family of cytokines, including myostatin, also known as "GDF8", Activin A, GDF11, etc.

Most of his work has employed the use of genetically modified mice. For example, mice which were made to be null for myostatin/GDF8 demonstrated almost a two-fold increase in skeletal muscle mass, which showed that myostatin is a natural inhibitor of muscle differentiation and growth.

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