Kirtimaan Syal

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Kirtimaan Syal
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NationalityIndian
CitizenshipIndia
Education
  • Bachelor of science in Microbiology
  • Master of Science and Doctor of Philosophy
Alma mater
  • Delhi University
  • Postgraduate Institute of Medical Education and Research
  • Indian Institute of Science
OccupationBiologist

Kirtimaan Syal is an Indian biologist. He is a faculty at the department of biological sciences at Birla Institute of Technology & Science, Pilani.

Contributions

He invented Syal Method for biofilm and biomass quantification which is after his name [1] and is being used by different researchers for academic and research purposes worldwide [2]. He has shown for the first time that Vitamin C, in addition to boosting immune responses in humans, can target stress response and survival of Mycobacterium smegmatis, a model organism of M tuberculosis [3][4][5]. Earlier, he has contributed towards the synthesis and characterization of sugar molecules that can act as antibacterial and are completely non-toxic to humans [6][7][8]. Further, he has contributed significantly towards the understanding of stress response and the emergence of multiple drug resistance in bacterial systems [9][10][11][12]. He was one of the first to calculate the reproductive number for COVID19 [13] and defined guidelines for newly identified limitations of diagnostics of COVID19 [14].

Education

Syal studied bachelor of science in Microbiology at Delhi University. He earned his Master of Science and Doctor of Philosophy from Postgraduate Institute of Medical Education and Research and Indian Institute of Science respectively.[15]. His Ph.D. thesis was entitled "Second messenger (p)ppGpp and stress response: Decoding key pathways by small molecule analogues, biophysical techniques, and mass spectrometry." His doctoral advisor was Dipankar Chatterji.[16] Syal did his postdoctoral studies from the University of Copenhagen,University of Wisconsin-Madison and St. Jude Children's Research Hospital for various durations.[17]

Career

Kirtimaan Syal is a faculty of biological sciences at Birla Institute of Technology and Sciences-Pilani, Hyderabad campus. His research focuses on second messenger signaling, regulation of transcription, and host-pathogen interaction.[18] He has been awarded several awards including Sun Pharma Award, DBT RLS fellowship to name a few.

References

  1. ↑ "Syal K. Novel Method for Quantitative Estimation of Biofilms. Curr Microbiol. (Springer) 2017 Oct;74(10):1194-1199. doi: 10.1007/s00284-017-1304-0. Epub 2017 Jul 14. PMID: 28710512".
  2. ↑ "Ali MK, Zhen G, Nzungize L, Stojkoska A, Duan X, Li C, Duan W, Xu J, Xie J. Mycobacterium tuberculosis PE31 (Rv3477) attenuates host cell apoptosis and promotes recombinant M. smegmatis intracellular survival via up-regulating GTPase guanylate binding protein-1. Frontiers in cellular and infection microbiology. 2020 Feb 7;10:40".
  3. ↑ "Syal K, Neerupma Bhardwaj, Dipankar Chatterji, Vitamin C targets (p)ppGpp synthesis leading to stalling of long-term survival and biofilm formation in Mycobacterium smegmatis, FEMS Microbiology Letters (Oxford University Press), Volume 364, Issue 1, January 2017, fnw282".
  4. ↑ "Vitamin C, THE HINDU, 2017".
  5. ↑ "Catherine Vilchèze and William R. JacobsJr (2019), The Isoniazid Paradigm of Killing, Resistance, and Persistence in Mycobacterium tuberculosis, Journal of Molecular Biology (Elsevier), 431, 18:23, 3450-3461. Paragraph-'...Interestingly, Syal and colleagues demonstrated that vitamin C inhibits...'".
  6. ↑ "New class of compounds inhibit bacterial biofilm growth, Bangalore Mirror, Times of India, 2016".
  7. ↑ "Down the synthetic route, DECCAN HERALD, 2016".
  8. ↑ "Syal, K., Maiti, K., Naresh, K. et al. Synthetic arabinomannan glycolipids impede mycobacterial growth, sliding motility and biofilm structure. Glycoconj J (Springer) 33, 763–777 (2016)".
  9. ↑ "Syal, K., Joshi, H., Chatterji, D. and Jain, V. (2015), Novel pppGpp binding site at the C-terminal region of the Rel enzyme from Mycobacterium smegmatis. The FEBS Journal (Wiley), 282: 3773-3785".
  10. ↑ "Syal K et al. Synthetic (p)ppGpp Analogue Is an Inhibitor of Stringent Response in Mycobacteria. Antimicrobial Agent Chemotherapy (American Society for Microbiology), 2017: 61: 6".
  11. ↑ "IISc makes two potent molecules to fight TB, THE HINDU, 2017".
  12. ↑ "Scientists Develop Molecules That Can Fight TB More Effectively Than Most Antibiotics, THE BETTER INDIA, 2017".
  13. ↑ "Syal K. COVID-19: Herd immunity and convalescent plasma transfer therapy. J Med Virol. (Wiley) 2020 Sep;92(9):1380-1382. Epub 2020 Jul 11. PMID: 32281679; PMCID: PMC7262166".
  14. ↑ "Syal, K. Guidelines on newly identified limitations of diagnostic tools for COVID-19 and consequences. J Med Virol. (Wiley) 2021; 93: 1837- 1842".
  15. ↑ "BITS-Pilani Profile".
  16. ↑ "Indian Institute of Science Web".
  17. ↑ "BITS-Pilani Web".
  18. ↑ "Google Scholar".

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