Juan Cabrera Garrido

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Juan Cabrera Garrido
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Born
Juan Ramón Cabrera Garrido

(1944-08-31) August 31, 1944 (age 77)
Granada, Spain
NationalitySpanish
CitizenshipSpain
EducationPhD
Alma materUniversity of Granada
Occupation
  • Physician
  • Vascular surgeon
  • Researcher
  • Inventor

Juan Ramón Cabrera Garrido (Granada, August 31, 1944) is a Spanish physician, vascular surgeon, researcher and the inventor of Microfoam sclerosing agents.

Biography outline

Born in 1944 in Granada (Spain), Juan Cabrera is the grandson, nephew, brother, and uncle of physicians. His grandfather, Fermín Garrido Quintana, was Professor of Anatomical Technique and Surgical Pathology and Dean of the University of Granada (1924–1930) and was Mayor of the City in 1931.

He graduated in Medicine (1970) at the University of Granada, where he was awarded his Doctorate (Summa cum laude) in 1977 and was a professor at the School of Medicine. He worked in the Regional Department of Vascular Surgery of the Virgen de la Nieves University Hospital of Granada as Head of Section until he took voluntary unpaid leave in 1996. Since then, he has dedicated his time to his private practice and research.

His investigations led to the discovery in 1993 of Microfoam sclerosing agents,[1] a new injectable pharmaceutical form for the non-surgical treatment of all types of varicose veins,[2] venous malformations,[3][4] varicose ulcers,[3] varicoceles and hemorrhoids.

Based on his patent[5] of this novel product, the British multinational BTG[6] developed a pharmaceutical specialty (the first of Spanish origin approved by the FDA) designated Varithena. This has been used in the United States since 2014 as an alternative to surgery and other ablative techniques for the treatment of large varicose veins.[7]

Research and development

In relation to the aforementioned discovery, he was the first to publish information on its application and outcomes in international scientific journals. He has also collaborated in books on venous diseases and their treatment:

  • Foam Sclerotherapy State of the Art [8](Paris, France: Éditions Phlebologiques Francaises; 2002).
  • Diagnóstico y terapéutica endoluminal: radiología intervencionista[9] (Barcelona, España: Masson; 2002).
  • The Vein Book, first Edition[10] (Burlington, EEUU: Elsevier Academic Press; 2007).
  • Sclerotherapie et maladie veineuse chronique superficielle[11] (Paris, France: Éditions Eska; 2007).
  • Venous Ulcers[12] (London, UK: Elsevier Academic Press; 2007).
  • A Textbook - Foam Sclerotherapy[13] (London, UK: The Royal Society of Medicine Press Ltd. ; 2008).
  • Hemangiomas and Vascular Malformations. An Atlas of Diagnosis and Treatment[14] (Verlag, Italy: Springer; 2009).
  • The Vein Book, second Edition[15] (New York, EEUU: Oxford University Press; 2014).

Honors

  • Full member of the Spanish Society of Angiology.
  • Honorary member of the International Union of Angiology.
  • Honorary member of the French Society of Phlebology.
  • Honorary member of the Brazilian Society of Angiology and Vascular Surgery.
  • Honorary member of the Pan-American Society of Phlebology and Lymphology.
  • Academician of the Royal Academy of Medicine and Surgery of Granada.
  • First prize of the Official College of Physicians of Granada (1996) for the study; "Ampliación de límites en escleroterapia: nuevos productos esclerosantes".
  • Honorary Mention in the "Cid Dos Santo - Boehringer Mannheim" Award of the University of Coimbra (Portugal) for his study "La voie anastomotique arterielle mamaire interne - epigastrique. Étude fonctional et valoration de son importance dans la pathologie du secteur aorto - iliaque".
  • Award of Special Mention for Research and Development from the Illustrious School of Pharmacists of Granada along with María Antonia García-Olmedo Domínguez (his wife) and Juan Ramón Cabrera García-Olmedo (his son).

References

  1. Gobin, JP; Benigni, JP (2006). "Précisions sur l´origine de la Mousse Sclerosant". Phlébologie. p. 119.
  2. Thompson, M. M. (2008). Endovascular intervention for vascular disease : principles and practice. Informa Healthcare. ISBN 978-1-4200-2095-3. OCLC 191869269.
    Earnshaw, J. J.; Murie, John A.; Joint Vascular Research Group. (2007). The evidence for vascular surgery. TFM. p. 199. ISBN 978-1-903378-45-8. OCLC 71165310.
    Almeida, Jose I. Atlas of endovascular venous surgery. pp. 186–193. ISBN 978-0-323-56852-4. OCLC 1048935140.
    Alam, Murad; Silapunt, Sirunya (2011). Treatment of leg veins. Saunders/Elsevier. p. 45, 57, 58. ISBN 978-1-4377-3617-5. OCLC 759158658.
    Sadick, Neil S.; Khilnani, Neil; Morrison, Nick (2013). Practical approach to the management and treatment of venous disorders. Springer. p. 3. ISBN 978-1-4471-2891-5. OCLC 812017693.
    Oxford Textbook of Vascular Surgery. Oxford University Press. August 2016. p. 690. doi:10.1093/med/9780199658220.001.0001. ISBN 978-0-19-965822-0.
    Vasudevan, Biju; Chatterjee, Manas; K., Shilpa. Procedural dermatosurgery : a step by step approach. p. 460. ISBN 978-93-5270-212-1. OCLC 1049824758.
    Venkataram, Mysore; Association of Cutaneous Surgeons of India. ACS(I) textbook of cutaneous and aesthetic surgery. pp. 460, 467. ISBN 978-93-5270-033-2. OCLC 1063430908.
  3. 3.0 3.1 Goldman, Mitchel P.; Guex, Jean-Jerome (2016). Sclerotherapy : treatment of varicose and telangiectatic leg veins. Elsevier Science Health Science. pp. 171, 251, 255. ISBN 978-0-323-37727-0. OCLC 959274899.
  4. Lee, Byung-Boong; Gloviczki, Peter; Blei, Francine. Vascular malformations : advances and controversies in contemporary management. p. 171. ISBN 978-0-367-25534-3. OCLC 1112138760.
  5. EP patent 0656203, Template:Cite patent/authors, "Injectable microfoam containing a sclerosing agent", published 1995-06-07, assigned to BTG International Ltd 
  6. "BTGplc".
  7. "Varithena".
    Carugo, Dario; Ankrett, Dyan N.; Zhao, Xuefeng; Zhang, Xunli; Hill, Martyn; O'Byrne, Vincent; Hoad, James; Arif, Mehreen; Wright, David D. I. (May 2016). "Benefits of polidocanol endovenous microfoam (Varithena®) compared with physician-compounded foams". Phlebology. pp. 283–295. doi:10.1177/0268355515589063. ISSN 1758-1125. PMC 4838175. PMID 26036246.
    Star, Phoebe; Connor, David E; Parsi, Kurosh (April 2018). "Novel developments in foam sclerotherapy: Focus on Varithena® (polidocanol endovenous microfoam) in the management of varicose veins". Phlebology: The Journal of Venous Disease. pp. 150–162. doi:10.1177/0268355516687864. ISSN 0268-3555.
    Gibson, Kathleen; Kabnick, Lowell; Varithena 013 Investigator Group (April 2017). "A multicenter, randomized, placebo-controlled study to evaluate the efficacy and safety of Varithena® (polidocanol endovenous microfoam 1%) for symptomatic, visible varicose veins with saphenofemoral junction incompetence". Phlebology. pp. 185–193. doi:10.1177/0268355516635386. ISSN 1758-1125. PMC 5405826. PMID 27013511.
    Todd, Kenneth L.; Wright, D. I.; VANISH-2 Investigator Group (October 2014). "The VANISH-2 study: a randomized, blinded, multicenter study to evaluate the efficacy and safety of polidocanol endovenous microfoam 0.5% and 1.0% compared with placebo for the treatment of saphenofemoral junction incompetence". Phlebology. pp. 608–618. doi:10.1177/0268355513497709. ISSN 1758-1125. PMID 23864535.
    Eckmann, David M. (December 2009). "Polidocanol for endovenous microfoam sclerosant therapy". Expert Opinion on Investigational Drugs. pp. 1919–1927. doi:10.1517/13543780903376163. ISSN 1744-7658. PMC 2787977. PMID 19912070.
  8. Cabrera J. "Application techniques for sclerosant in microfoam form" y "Microfoam, a novel pharmaceutical dosage form for Sclerosants" En: Foam Sclerotherapy State of the Art. Editions Phlebologiques Francaises 46 rue SaintLambert Paris, ISBN 2-85480-958-0 pp. 17-20, 2002. 33
  9. Carreira Villamor, José Martín; Alarcón Fernández, Onofre (2002). Diagnóstico y terapéutica endoluminal : radiología intervencionista. Masson. ISBN 84-458-1127-4. OCLC 52744256.
  10. Cabrera, Juan; Cabrera, Juan Jr; García-Olmedo, María Antonia (2007). Bergan, John J. (ed.). The Vein Book. Elsevier. pp. 209–217. ISBN 978-0-12-369515-4.
  11. Gobin, Jean-Pierre; Benigni, Jean-Patrick; Impr. Barnéoud) (2006). Sclérothérapie et maladie veineuse chronique superficielle. Éd. Eska. ISBN 2-7472-0755-2. OCLC 470779668.
  12. Cabrera, J; Redondo, P (2007). Venous Ulcers. Academic Press. pp. 199–213. ISBN 978-0-12-373565-2.
  13. Bergan, John J.; Cheng, Van Le (2008). Foam Sclerotherapy : a textbook. Royal Society of Medicine Press Ltd. pp. 199–218. ISBN 1-85315-771-6. OCLC 1131590824.
  14. Cabrera J., Rubia M.V., Loose D.A. (2015) Sclerotherapy in Vascular Malformations with Polidocanol Foam. In: Mattassi R., Loose D., Vaghi M. (eds) Hemangiomas and Vascular Malformations. Springer, Milano. pp. 277–289.
  15. Cabrera, J; Rubia, MV (2013). Bergan, John J.; Bunke-Paquette, Nisha (eds.). The vein book. Oxford University Press, USA. pp. 166–174. ISBN 978-0-19-975019-1. OCLC 865331916.

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