Horacio D. Espinosa

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Horacio D. Espinosa

MAE
EducationBrown University (PhD)

Politecnico di Milano (MS)

Universidad Nacional del Nordeste (BE)
Scientific career
Fields
  • Nanomechanics
  • Materials Science
  • Bioengineering
Institutions
  • Northwestern University
Doctoral advisorsRodney Clifton
Michael Ortiz

Horacio D. Espinosa MAE is an Argentine-American engineer and academic at Northwestern University. He is the Walter P. Murphy Professor of Mechanical Engineering and directs the university's Theoretical and Applied Mechanics (TAM) Program. His research focuses on nanomechanics, bio-inspired materials, and experimental mechanics. He was elected to the U.S. National Academy of Engineering (NAE) in 2020 and named a Fellow of the National Academy of Inventors (NAI) in 2024.

Early Life and Education

Espinosa was born in Resistencia, Chaco, Argentina. He received his civil engineering degree from the Universidad Nacional del Nordeste in 1981. After working as a structural engineer in Argentina, he earned a M.Sc. in Structural Engineering from Politecnico di Milano (1987), followed by a M.Sc. in Applied Mathematics (1990) and a Ph.D. in Solid Mechanics (1992) from Brown University.[1][2]

Academic Career

Espinosa began his academic career as an assistant professor at Purdue University in 1992, where he was promoted to associate professor with tenure in 1998.[3] He joined Northwestern University in 2000. He is also a co-founder and director of Northwestern University's Institute for Cellular Engineering Technologies (iCET), established in 2015.[4]

Espinosa is the founder of Infinitesimal LLC, a Northwestern University spin-off company focused on microfluidic platforms for single-cell manipulation and analysis.[5][6] The company has received U.S. government Small Business Innovation Research and Small Business Technology Transfer (SBIR/STTR) funding and collaborates with academic and industrial partners.[7][8]

Professional services

Espinosa has held a number of leadership and editorial roles in professional societies and academic initiatives. He served as President of the Society of Engineering Science (SES) in 2012.[9] He was Chair of the U.S. National Committee on Theoretical and Applied Mechanics (USNC/TAM) from 2022 to 2024.[10] He has also served as a delegate to the International Union of Theoretical and Applied Mechanics (IUTAM) General Assembly.[11]

In scholarly publishing, Espinosa was Editor-in-Chief of the Journal of Experimental Mechanics from 2006 to 2010 and has served as co-editor of the Wiley Book Series in Micro and Nanotechnologies.

Research Contributions

Espinosa’s research spans nanomechanics, bioinspired materials, metamaterials, and cellular engineering, with contributions integrating experimental and computational approaches across multiple length scales.[12] His work includes the development of micro- and nano-electromechanical systems (MEMS/NEMS) for in situ electron microscopy–based mechanical testing of nanoscale materials such as carbon nanotubes, semiconducting nanowires, and two-dimensional materials.[13][14][15] He has also conducted atomic-scale experimental and computational studies on the mechanical properties of carbon nanotubes and on size-dependent elasticity and failure mechanisms in nanowires.[16][17]

In the area of two-dimensional materials, Espinosa has contributed to fracture mechanics through atomistic measurements and modeling of intrinsic fracture toughness, including J-integral–based analyses applied to monolayer transition metal dichalcogenides such as MoSe₂ and MoS₂.[18][19] His research on natural composites has examined toughening mechanisms in biological materials such as nacre and sea urchin teeth, and has informed the design of bio-inspired metamaterials with functional properties including wave filtering.[20][21][22]

Espinosa has developed microfluidic platforms for single-cell electroporation and gene editing, including systems enabling intracellular delivery and sampling of biomolecules, with applications in cell therapy and precision medicine.[23][24][25][26][27][28]

Honors and Awards

  • National Science Foundation CAREER Award (1996)[29]
  • Elected Fellow of the American Society of Mechanical Engineers (2004)[30]
  • Elected Fellow of the Society for Experimental Mechanics (2009)[31]
  • Sia Nemat-Nasser Medal, Society for Experimental Mechanics (2013)[32]
  • Elected Fellow of the American Association for the Advancement of Science (FAAAS) (2013)[33]
  • Murray Medal, Society for Experimental Mechanics (2016)[34]
  • William Prager Medal, Society of Engineering Science (2019)[35]
  • Member of the Academia Europaea (2019)[36]
  • Elected Fellow of the American Academy of Mechanics (2019)[37]
  • Elected member of the U.S. National Academy of Engineering (2020)[38]
  • Drucker Medal, American Society of Mechanical Engineers (2022)[39]
  • Fellow of the National Academy of Inventors (2024)[40]
  • Horace Mann Medal, Brown University (2025)[41]
  • Zdeněk P. Bažant Medal, American Society of Civil Engineers (2026)[42]

References

  1. ↑ "Engineering the Future: How Horacio Espinosa is Revolutionizing Medicine and Material Science". Brown University.
  2. ↑ "Engineering alumnus Horacio Espinosa elected to the NAE". Brown University.
  3. ↑ "Purdue faculty members earn promotions". Purdue.edu.
  4. ↑ "Message from the Directors". ICET.
  5. ↑ "Infinitesimal LLC". Northwestern University.
  6. ↑ "Espinosa, Sargent Named to National Academy of Inventors". Northwestern Engineering.
  7. ↑ "SBIR/STTR Portfolio". SBIR.
  8. ↑ "Leveraging AI to work with cells". Phys.org.
  9. ↑ "Past Presidents". Society of Engineering Science.
  10. ↑ "U.S. National Committee on Theoretical and Applied Mechanics". National Academies.
  11. ↑ "U.S. National Committee for Theoretical and Applied Mechanics (USNC/TAM)". Nationalacademies.org.
  12. ↑ Barthelat, Francois; Zavattieri, Pablo; Zhu, Yong (2021-10-01). "Preface—Horacio D. Espinosa". Extreme Mechanics Letters. 48 101449. Bibcode:2021ExML...4801449B. doi:10.1016/j.eml.2021.101449. ISSN 2352-4316.
  13. ↑ Zhu, Yong; Espinosa, Horacio D. (2005-10-11). "An electromechanical material testing system for in situ electron microscopy and applications". Proceedings of the National Academy of Sciences. 102 (41): 14503–14508. Bibcode:2005PNAS..10214503Z. doi:10.1073/pnas.0506544102. PMC 1253576. PMID 16195381.
  14. ↑ Haque, M.A.; Espinosa, H.D.; Lee, H.J. (2010). "MEMS for In Situ Testing—Handling, Actuation, Loading, and Displacement Measurements". MRS Bulletin. 35 (5): 375–381. doi:10.1557/mrs2010.570. ISSN 0883-7694.
  15. ↑ "World's smallest universal material testing system". Archived from the original on 2019-12-17. Retrieved 2026-02-01.
  16. ↑ Stach, Eric (2008). "Nanotubes reveal their true strength". Nature Nanotechnology. 3 (10): 586–587. Bibcode:2008NatNa...3..586S. doi:10.1038/nnano.2008.293. ISSN 1748-3395. PMID 18838994.
  17. ↑ Espinosa, Horacio D.; Bernal, Rodrigo A.; Filleter, Tobin (2013-01-10), "In-Situ TEM Electromechanical Testing of Nanowires and Nanotubes", in Espinosa, Horacio D.; Bao, Gang (eds.), Nano and Cell Mechanics (1 ed.), Wiley, pp. 191–226, doi:10.1002/9781118482568.ch8, ISBN 978-1-118-46039-9, retrieved 2026-02-01
  18. ↑ Zhang, Xu; Nguyen, Hoang; Zhang, Xiang; Ajayan, Pulickel M.; Wen, Jianguo; Espinosa, Horacio D. (2022-11-08). "Atomistic measurement and modeling of intrinsic fracture toughness of two-dimensional materials". Proceedings of the National Academy of Sciences. 119 (45) e2206756119. Bibcode:2022PNAS..11906756Z. doi:10.1073/pnas.2206756119. ISSN 0027-8424. PMC 9659395. PMID 36331995.
  19. ↑ Zhang, Yue; Li, Chunyu; Zhang, Xu; Wen, Jianguo; Sumant, Anirudha V.; Strachan, Alejandro; Espinosa, Horacio D. (2025). "Large scale polymer toughening of two-dimensional materials revealed by in situ TEM fracture tests and multiscale simulations". European Journal of Mechanics - A/Solids. 114 105748. Bibcode:2025EuJMA.11405748Z. doi:10.1016/j.euromechsol.2025.105748.
  20. ↑ Espinosa, Horacio D.; Rim, Jee E.; Barthelat, Francois; Buehler, Markus J. (2009-11-01). "Merger of structure and material in nacre and bone – Perspectives on de novo biomimetic materials". Progress in Materials Science. 54 (8): 1059–1100. Bibcode:2009PrMS...54.1059E. doi:10.1016/j.pmatsci.2009.05.001. ISSN 0079-6425.
  21. ↑ Espinosa, Horacio D.; Juster, Allison L.; Latourte, Felix J.; Loh, Owen Y.; Gregoire, David; Zavattieri, Pablo D. (2011-02-01). "Tablet-level origin of toughening in abalone shells and translation to synthetic composite materials". Nature Communications. 2 (1) 173. Bibcode:2011NatCo...2..173E. doi:10.1038/ncomms1172. ISSN 2041-1723. PMID 21285951.
  22. ↑ Espinosa, Horacio D.; Zaheri, Alireza; Nguyen, Hoang; Restrepo, David; Daly, Matthew; Frank, Michael; McKittrick, Joanna (2019). "In situ Wear Study Reveals Role of Microstructure on Self-Sharpening Mechanism in Sea Urchin Teeth". Matter. 1 (5): 1246–1261. doi:10.1016/j.matt.2019.08.015. ISSN 2590-2385.
  23. ↑ Yang, Ruiguo; Lemaître, Vincent; Huang, Changjin; Haddadi, Abbas; McNaughton, Rebecca; Espinosa, Horacio D. (2018). "Monoclonal Cell Line Generation and CRISPR/Cas9 Manipulation via Single-Cell Electroporation". Small. 14 (12) 1702495. Bibcode:2018Small..1402495Y. doi:10.1002/smll.201702495. ISSN 1613-6810. PMC 6016377. PMID 29430869.
  24. ↑ Kang, Wonmo; Giraldo-Vela, Juan P.; Nathamgari, S. Shiva P.; McGuire, Tammy; McNaughton, Rebecca L.; Kessler, John A.; Espinosa, Horacio D. (2014-09-10). "Microfluidic device for stem cell differentiation and localized electroporation of postmitotic neurons". Lab Chip. 14 (23): 4486–4495. doi:10.1039/C4LC00721B. ISSN 1473-0197. PMC 4251430. PMID 25205561.
  25. ↑ Patino, Cesar A.; Mukherjee, Prithvijit; Berns, Eric J.; Moully, Elamar Hakim; Stan, Liliana; Mrksich, Milan; Espinosa, Horacio D. (2022-05-24). "High-Throughput Microfluidics Platform for Intracellular Delivery and Sampling of Biomolecules from Live Cells". ACS Nano. 16 (5): 7937–7946. Bibcode:2022ACSNa..16.7937P. doi:10.1021/acsnano.2c00698. ISSN 1936-0851. OSTI 1969392. PMID 35500232.
  26. ↑ Pathak, Nibir; Patino, Cesar A.; Ramani, Namrata; Mukherjee, Prithvijit; Samanta, Devleena; Ebrahimi, Sasha B.; Mirkin, Chad A.; Espinosa, Horacio D. (2023). "Cellular Delivery of Large Functional Proteins and Protein–Nucleic Acid Constructs via Localized Electroporation". Nano Letters. 23 (8): 3653–3660. Bibcode:2023NanoL..23.3653P. doi:10.1021/acs.nanolett.2c04374. PMC 10433461. PMID 36848135. Retrieved 2026-02-01.
  27. ↑ Branca, Malorye (2022-03-23). "New AI-Supported Electroporation Platform Enables CRISPR/Cas". Inside Precision Medicine. Retrieved 2026-02-01.
  28. ↑ "New method allows cells to be sampled over time, offering window to responses that evolve". Archived from the original on 2023-05-24. Retrieved 2026-02-01.
  29. ↑ "NSF awards fund seven young faculty members". Purdue.edu.
  30. ↑ "ASME Fellows" (PDF). ASME.
  31. ↑ "SEM Fellows". Society for Experimental Mechanics.
  32. ↑ "S. Nemat-Nasser". Society for Experimental Mechanics.
  33. ↑ "AAAS Council Elects 388 New AAAS Fellows". AAAS.
  34. ↑ "Murray Medal". Society for Experimental Mechanics.
  35. ↑ "William Prager Medal". Society of Engineering Science.
  36. ↑ "Espinosa Horacio Dante". Academy of Europe.
  37. ↑ "Fellows". American Academy of Mechanics.
  38. ↑ "National Academy of Engineering Elects 86 Members and 18 International Members". NAE.
  39. ↑ "Daniel C. Drucker Medal". ASME.
  40. ↑ "2024 Fellows List" (PDF). National Academy of Inventors.
  41. ↑ "Horace Mann Medal | Graduate School". Brown.edu. 29 April 2025.
  42. ↑ "Zdeněk P. Bažant Medal for Failure and Damage Prevention Past Award Winners". ASCE.

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