Gabriel Otte

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Gabriel Otte
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Born
United States
EducationUniversity of Balamand (Master of Theology), Cornell University (B.A. in Chemistry and Chemical Biology)
OccupationEntrepreneur, software engineer, researcher
Known for
  • Freenome and Dinari (Co-founder)
  • Healthcare Co-op (Partner)

Gabriel Otte is an American entrepreneur, software engineer, and researcher.[1][2] He is the co-founder of the biotechnology company Freenome and the fintech firm Dinari, and is a partner at Healthcare Co-op.[3][4][5]

Early life and education

Otte graduated from Cornell University with a B.A. in Chemistry and Computational Biology in 2011.[6] During and after his undergraduate years, he worked as a research assistant at Cornell, contributing to biomedical research linking small blood vessel diseases to Alzheimer’s disease.[7]

He later earned a Master of Theology through the Antiochian House of Studies in conjunction with the University of Balamand in Lebanon.[8]

Career

Otte began his career by joining Apple as a software engineer.[3] He also worked as a software engineer at Glyde Corporation.[9]

In 2014, Otte co-founded Freenome, a biotech company that applies machine learning and genomics for early cancer detection through blood-based diagnostic tests.[10][11][12][13] He served as CEO of the company from 2016 until 2021.[14][15]

While at Freenome, Otte also became a Partner at Healthcare Co-op in May 2018, and he continues to be actively involved in that role.[16]

After his time at Freenome, he shifted his focus to the blockchain and finance sectors. He co-founded Dinari, a startup designed to tokenize real-world assets, including U.S. equities, with the goal of making stock trading more accessible and decentralized.[17] Under his co-leadership, Dinari secured substantial funding and worked toward regulatory compliance, including registering as a transfer agent with the United States Securities and Exchange Commission to support tokenized stock trading.[18][19][20]

Otte was featured in Forbes 30 Under 30 in 2017.[21]

Selected publications

Some of Otte's selected publications include:

  • Wan, Nathan; Weinberg, David; Liu, Tzu-Yu; Niehaus, Katherine; Otte, Gabriel L.; Delubac, Daniel; Kannan, Ajay; White, Brandon; Bailey, Mitch; Bertin, Marvin; Boley, Nathan; Bowen, Derek; Cregg, James; Drake, Adam M.; Ennis, Riley (2019-08-23). "Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA". BMC Cancer. 19 (1): 832. doi:10.1186/s12885-019-6003-8. ISSN 1471-2407. PMC 6708173. PMID 31443703.
  • Nelson, David M.; Jaber-Hijazi, Farah; Cole, John J.; Robertson, Neil A.; Pawlikowski, Jeffrey S.; Norris, Kevin T.; L. Otte, Gabriel (2016-07-25). "Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability". Genome Biology. 17 (34) 158. doi:10.1186/s13059-016-1017-x. ISSN 1474-760X. PMC 4967351. PMID 27455871.
  • Butin-Israeli, Veronika; Adam, Stephen A.; Jain, Nikhil; Otte, Gabriel L.; Neems, Daniel; Wiesmüller, Lisa; Berger, Shelly L.; Goldman, Robert D. (2015-03-05). "Role of lamin B1 in chromatin instability". Molecular and Cellular Biology. 35 (5): 884–898. doi:10.1128/MCB.01145-14. ISSN 0270-7306. PMC 4323489. PMID 25535332.

Philanthropy

In 2017, Otte and his wife established the Otte Family Capital foundation, which supports initiatives in healthcare, technology, and faith-based programs.[14] He is also an ordained deacon at St. Stephen Orthodox Church in Campbell, California, under the Antiochian Orthodox Christian Archdiocese of North America.[14]

References

  1. "This Biotech CEO Doesn't Have A PhD, But He Did Leave School Under A Cloud". BuzzFeed News. Archived from the original on 2025-07-15. Retrieved 2026-01-18.
  2. "This Entrepreneur Developed A Test That Diagnosed His Dad With Cancer". Fast Company. 2016-04-01. Archived from the original on 2022-08-21. Retrieved 2026-01-18.
  3. 3.0 3.1 Ramsey, Lydia (2016-06-09). "A 27-year-old who worked for Apple as a teenager wants to make a yearly blood test to diagnose cancer". Yahoo Finance. Retrieved 2025-08-20.
  4. Kuchler, Hannah (2024-07-19). "Freenome raises $160m as it readies early detection cancer tests". Financial Times. Retrieved 2025-08-20.
  5. Taylor, Nick Paul (2017-03-01). "Liquid biopsy play Freenome bags $65M in Andreessen Horowitz-led round | Fierce Biotech". www.fiercebiotech.com. Retrieved 2026-01-18.
  6. Hovis, Kathy. "Alum's company uses machine learning, chemistry to detect cancer". ezramagazine.cornell.edu. Retrieved 2025-08-20.
  7. Nishimura, Nozomi; Kersbergen, Calvin; Ivasyk, Iryna; Cruz, Jean; Zhou, Joan; Beverly, Jeffrey; Otte, Gabriel; Karlsson, Per; Slack, Elizabeth; Santisakultarm, Thom P.; Iadecola, Costantino; Schaffer, Chris (2013). "P1–035: Stalled blood flow in cortical capillaries, caused by recurrent plugging by leukocytes, contributes to brain blood flow reductions in mouse models of Alzheimer's disease". Alzheimer's & Dementia. 9 (4S_Part_4): P164–P165. doi:10.1016/j.jalz.2013.05.255. ISSN 1552-5279.
  8. "Dn. Gabriel Otte | Ancient Faith Ministries". www.ancientfaith.com. Retrieved 2025-08-20.
  9. Terry, Mark (2017-12-07). "What You Need to Know About Freenome". BioSpace. Retrieved 2025-08-20.
  10. Wan, Nathan; Weinberg, David; Liu, Tzu-Yu; Niehaus, Katherine; L. Otte, Gabriel; Delubac, Daniel; Kannan, Ajay; White, Brandon; Bailey, Mitch; Bertin, Marvin; Boley, Nathan; Bowen, Derek; Cregg, James; Drake, Adam M.; Ennis, Riley (2019-08-23). "Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA". BMC Cancer. 19 (1): 832. doi:10.1186/s12885-019-6003-8. ISSN 1471-2407. PMC 6708173. PMID 31443703.
  11. Farr, Christina (2017-04-28). "Tech VCs are barging into the life sciences, and writing big checks". CNBC. Retrieved 2025-08-20.
  12. "This Startup Wants To Catch Cancer In Its Early Days". BuzzFeed News. Archived from the original on 2024-06-22. Retrieved 2025-08-20.
  13. Conger, Kate (2019-07-24). "With $160 million in new funding, Freenome looks to commercialize its blood test to detect colorectal cancer". TechCrunch.
  14. 14.0 14.1 14.2 "SVOTS Board of Trustees Welcomes New Members at Fall Meeting". St Vladimir's Orthodox Theological Seminary. 2024-12-11. Retrieved 2025-08-20.
  15. Herper, Matthew (2021-05-21). "Freenome, high-profile liquid biopsy company, quietly replaces its CEO". Stat News. Retrieved 2026-01-18.
  16. Rosales, Kayelee. "All You Need To Know About Gabriel Otte, The Co-Founder of Dinari". usethebitcoin.com. Retrieved 2026-01-18.
  17. Yuzhyk, Fiodar; Vargas, Maximilian (2025-08-15). "Tokenized Stocks Provider Dinari Announces Layer-1 Blockchain, Building "Onchain DTCC"". Crypto Briefing. Retrieved 2025-08-20.
  18. McGrath, Catherine. "Exclusive: Tokenized asset company Dinari raises $12.7 million from Hack VC and Blockchange Ventures". Fortune Crypto. Retrieved 2025-08-20.
  19. Lang, Hannah; Lang, Hannah (2025-06-26). "Dinari granted first broker-dealer registration to offer tokenized stocks". Reuters. Retrieved 2025-08-20.
  20. Shen, Muyao (2023-08-21). "Crypto Startup Aims to Tokenize Stocks by Playing by the Rules". Bloomberg News. Retrieved 2025-08-20.
  21. Hedgecock, Sarah. "30 Under 30 Healthcare: The Researchers, Entrepreneurs And Policymakers Who Will Save Your Life". Forbes. Retrieved 2025-08-20.

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