Zorecimeran, trade-named CVnCoV is a COVID-19 vaccine candidate developed by CureVac and Coalition for Epidemic Preparedness Innovations (CEPI). Zorecimeran is an messenger RNA technology programmed with information about the coronavirus protein as an unknown pathogen, and activates the immune system against it. As an mRNA vaccine, zorecimeran has established safety, and provides a minimal, harmless piece of the coronavirus spike protein to initiate an immune response against COVID-19 disease. Zorecimeran technology does not interact with the human genome.
Clinical trial progress
In November 2020, CureVac reported results of a Phases of clinical I clinical trial that zorecimeran (CVnCoV) was well-tolerated, safe, and produced a robust immune response. In December, CureVac began a Phases of clinical research#Phase III clinical trial of zorecimeran with 36,500 participants. Bayer will provide clinical trial support and international logistics for the Phase III trial, and may be involved in eventual manufacturing should the vaccine prove to be safe and effective.
Manufacturing of mRNA vaccines can be performed rapidly in high volume, including use of portable, automated printers ("RNA microfactories") for which CureVac has a joint development partnership with Tesla, Inc.
mRNA vaccines require stringent cold chain refrigeration throughout manufacturing, distribution and storage. The CureVac technology for zorecimeran uses a non-modified, more natural mRNA less affected by hydrolysis, enabling storage at 5 °C (41 °F) and relatively simplified cold chain requirements that facilitate up to three months of storage and distribution to world regions that do not have specialized ultracold freezer.
CureVac has a European-based network to accelerate manufacturing of zorecimeran, if proven safe and effective, for production of up to 300 million doses in 2021 and 600 million doses in 2022. An estimated 405 million doses will be provided to EU states.
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Proposed INN: "Zorecimeran"
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