Zakarya Kunsulu

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Kunsulu Zakarya
Born1967.02.07
Qarsaqbay village, Ulytau district, Ulytau region, Republic of Kazakhstan
NationalityKazakh
CitizenshipRepublic of Kazakhstan
Alma materZhubanov Aktobe Regional State University
AwardsDoctor of Biological Sciences (2002)

Professor Academician Badge "For merits in the development of science in Kazakhstan" (2017) Medal "People's Gratitude" (Kazakhstan) (2020) Letter of thanks from the President of the Republic of Kazakhstan K. Tokayev (2020) Best Engineer of the Year (2020) Badge "For contribution to the development of healthcare" (2021) Laureate of the State Prize of the Republic of Kazakhstan in the field of science and technology named after Al-Farabi (2021)

Winner of the National Competition "30 zhyl 30 esim" (2021)
Scientific career
FieldsBiology
InstitutionsDirector General of the Research Institute of Biological Safety Problems

Kunsulu Daltonovna Zakarya (July 2, 1967) is a prominent Kazakh scientist in the field of biological safety. Director General of the Research Institute of Biological Safety Problems, Doctor of Biological Sciences, Professor, Laureate of the State Prize of the Republic of Kazakhstan in the field of science and technology named after Al-Farabi, full member of the Academy of Natural Sciences, Corresponding Member of the Russian Academy of Natural Sciences.

Developer of Kazakhstan inactivated vaccine QazCovid-in (QazVac) against coronavirus infection COVID-19. Developer of technology for the production of inactivated vaccine QazCovid-in (QazVac) against coronavirus infection COVID-19.

Chairman of the Impartiality Committee of JSC "National Center for Expertise and Certification" (NatExC).

Editor-in-chief of the scientific journal "Biosafety and Biotechnology".

Honorary Professor of Al-Farabi Kazakh National University. Member of the Board of Directors of Al-Farabi Kazakh National University. Certified auditor according to international standards: ISO 19011:2002 – environmental management; ISO 15189:2007 – medical management; ISO 9001:2000 – quality management; OHSAS 18001:2007 – occupational safety and health management. National technical expert on the international standard ISO 15189-2007 "Medical laboratories. Specific requirements for quality and competence". Member of the Expert Council and technical expert of JSC "National Agency for Technological Development".[1]

Member of the Political Council of the "AMANAT" Party. Member of the National "Kurultai"[2]. Kazakhstani Patriot of the Year – 2022[3]. Honored Inventor of the Republic of Kazakhstan-2022[4].

Biography

She was born on July 2, 1967 in the working village of Karsakpai, Ulytau district, Karaganda region.

In 1995 she defended her dissertation for the degree of Candidate of Biological Sciences (Almaty), in 2002 she defended her dissertation for the degree of Doctor of Biological Sciences in Moscow. Studying at the International University of Venice, the course “Sustainable Development – Sustainable development". Internship at K-Water company “Hydro-infra Development & Management – Development and management of biological resources and water infrastructure” in Republic of Korea.

Father: Kaliev Dalton Zakarievich (1934-2015), graduate of the Kazakh Mining and Metallurgical Institute of Almaty, metallurgical engineer for non-ferrous and precious metals (1952-1957), chief engineer of the Karsakpai Metallurgical Plant, chief Technical Inspector of industry of the Aktobe region.

Mother: Iglikova Zhansulu Abu-Talipovna (born 1937), graduated from the Biology and Chemistry Faculty of Karaganda State University named after E.Buketov, Honored Teacher of Kazakhstan, teaching experience of more than 50 years.

Grandfather: Kaliev Zakarya Kalievich (1900-1936), graduated from the Leningrad Institute of National Economy, grain economist (1925-1931), head of the KazNarkomSnab industry group (1931-1933), participated in the fight against hunger.

Grandfather: Iglikov Abu-Talip (1889-1950), graduated from the Ural Pedagogical Institute, teacher, veteran of the Great Patriotic War.[5]

Labor activity

• 1989-2003 West Kazakhstan State Medical Academy named after M. Ospanov. Positions: assistant, associate Professor, Chairman of the Council of Young Scientists, head of the Patent Department, Head of the Department of Natural Sciences.

• 2003-2006 Professor, Head of Departments and Departments of Science and International Relations at Zhangir Khan State Technical University, K. Zhubanov Aktobe regional state university, Khoja Ahmed Yasawi International Kazakh-Turkish University.

• 2006-2008 worked in the Central Office of the Ministry of Environmental Protection of the Republic of Kazakhstan.

• 2008-2013 Director of the Department of Science of the RSE "National Center of Biotechnology of the Republic of Kazakhstan" Science Commitee of Ministry of education and science of Republic of Kazakhstan.

• 2013-2018 Deputy Director General of the RSE "Republican collection of Microorganisms" of the cience Commitee of Ministry of education and science of Republic of Kazakhstan.

• Since 20.12.2018, General Director of the RSE "Scientific Research Institute of Biological Safety Problems" of the Ministry of Health of the Republic of Kazakhstan.

Scientific activity

Author of more than 230 scientific publications, 8 scientific and methodological manuals, 5 monographs, 32 invention patents, including 2 international patents, 10 regulatory and technical documents for the production of preventive and diagnostic drugs. Editor-in-Chief of the scientific journal "Biosafety and Biotechnology".

Developer of Kazakhstani inactivated vaccine against COVID-19 coronavirus QazCovid-in (QazVac). Developer of the production technology for the inactivated QazCovid-in vaccine against COVID-19 coronavirus infection. Under the guidance of the scientist, live, subunit and two recombinant vaccines against coronavirus infection were developed.

She managed, coordinated, monitored and controlled the implementation of 10 scientific and technical programs in the field of biotechnology, biosafety and microbiology, including more than 200 scientific projects, including 22 international projects. Scientific supervisor of 3 scientific and technical programs in the field of biological safety. Co-director of the scientific and technical program "Development of a vaccine against coronavirus infection COVID-19". Winner of two World Bank competitions for technology commercialization programs.[1]

The main results of their research have been published as scientific articles in highly ranked international journals such as EClinicalMedicine by Lancet, Frontiers in Microbiology, Infectious Diseases of Poverty, Veterinary Microbiology, Tropical Animal Health and Production, Plant Protection Science and others.[6]

Main scientific works

1. Zakarya K., Kutumbetov L., Orynbayev M., Abduraimov Y., Sultankulova K., Kassenov M., Sarsenbayeva1 G., Kulmagambetov I., Davlyatshin T., Stukova M., Khairullin B.Safety and immunogenicity of a QazCovid-in® inactivated whole-virion vaccine against COVID-19 in healthy adults: a single-centre, randomised, single-blind, placebo-controlled phase 1 and an open-label phase 2 clinical trials with a 6 months follow-up in Kazakhstan. EClinicalMedicine 00 (2021) 101078 [1] by the LANCET).

2. Zhugunissov K., Zakarya K.,Khairullin B., Orynbayev M.,Abduraimov Y.,Kassenov M.,Sultankulova K.,Kerimbayev A.,Nurabayev S.,Myrzhakhmetova B.,Nakhanov A.,Nurpeisova A.,Cherviyakova O.,Assanzhanova N., Burashev Y.,Mambetaliev M.,Azanbekova M.,Kopeyev S.,Kozhabergenov N. Isabek A.,Kutumbetov L.Development of the inactivated qazcovid-in vaccine: protective efficacy of the vaccine in syrian hamsters. Front. Microbiol. 12:720437. doi: 10.3389/fmicb.2021.720437.

3. Bugybayeva D., Kydyrbayev Zh., Zinina N., Assanzhanova N., Yespembetov B., Kozhamkulov Y., Zakarya K., Ryskeldinova Sh., TabynovK.A new candidate vaccine for human brucellosis based on infuenza viral vectors: a preliminary investigation for the development of an immunization schedule in a guinea pig model. Infectious Diseases of Poverty. 2021. Vol.10. P.1-10.

4. A., Yskakova G., Maulenbay A., Zakarya K., Rsaliyev Sh.Virulence and race structure of Pucciniagraminisf.sp. triticiin Kazakhstan. Plant Protection Science. 2020. Vol. 56 (4). P. 275—284. 5. Zhugunissov K., Bulatov Ye., Orynbayev M., Kutumbetov L., Abduraimov Ye., Shaiyakhmetov Ye., Taranov D., Amanova, Mambetaliev Zh.M., AbsatovaZh., Azanbekova M., Khairullin B., Zakarya K., Tuppurainen E.Goatpox virus (G20-LKV) vaccine strain elicits a protective response in cattle against lumpy skin disease at challenge with lumpy skin disease virulent field strain in a comparative study. Veterinary Microbiology. 2020. Vol.245. doi: 10.1016/j.vetmic.2020.108695.

6. Issabek A., Burashev Ye., Chervyakova O., Orynbayev M., Kydyrbayev Zh., Kassenov M., Zakarya K., Sultankulova K.Complete Genome Sequence of the Highly Pathogenic Strain A/Domestic Goose/Pavlodar/1/05 (H5N1) of the Avian Influenza Virus, Isolated in Kazakhstan in 2005. Microbiology Resource Announcements. 2020. Vol. 9(10). DOI: 10.1128/MRA.00109-20.

7. Orynbayev M.B., Nissanova R.K., Khairullin B.M., Issimov A., Zakarya K.D., Sultankulova K.T., Kutumbetov L.B., Tulendibayev A.B., Myrzakhmetova B.Sh., Burashev E.D., Nurabayev S.S., Chervyakova O.V., Nakhanov A.K., Kock R.A.Lumpy skin disease in Kazakhstan. Tropical Animal Health and Production. 2021. Vol.53(166). P.2-7.

8. Orynbayev M.B.,Nissanova R.K., Argimbayeva T.U., Zakarya K.D., Myrzakhmetova B.S., Melisbek A.M., Barmak S.M., Issabek A.U., Nakhanov A.K.,Shevtsov A., Kozhabergenov N.S., Sultankulova K.T.Genomic sequence of the new attenuated vaccine strain Neethling-RIBSP of the lumpy skin disease virus. Microbiology Resource Announcements. 2020. Vol. 9(26). DOI: 10.1128/MRA.00318-20.[7]

Main patents

1. Kutumbetov L. B., Orynbayev M. B., Zakarya K. D., Kerimbayev A. A., Zhugunisov K. D., Sultankulova K. T., Myrzakhmetova B. Sh., Nakhanov A. K., Kasenov M. M., Abduraimov E. O., Khairullin B. M., Kopeev S. K. Strain "SARS-CoV-/KZ_Almaty/04.2020" COVID-19 coronavirus infection, used for the preparation of specific prophylaxis, laboratory diagnostics and evaluation of the effectiveness of biological protection of vaccines against COVID-19 coronavirus infection. Patent number: No. .34762 dated 08.12.2020.

2. Kutumbetov L. B.,Kerimbayev A. A.,Myrzakhmetova B. Sh., Orynbayev M. B.,Zakarya K.,Zhugunisov K. D.,Sultankulova K. T.,Kasenov M. M.,Abduraimov E. O.,Khairullin B. M.,Nurabaev S. Sh.,Nakhanov A. K.,Attenuated strain "SARS-CoV-2/NIIPBB-2021" of the COVID-19 coronavirus infection virus, used for the preparation of specific prophylaxis and laboratory diagnostics of the disease. № 35175. 02.07.2021.

3. Nakhanov A. K.,Chervyakova O. V.,Tailakova E. T.,Isabek A. U.,Sultankulova K. T., Orynbayev M. B.,Zakarya K. D.,Kutumbetov L. B.,Terebay A. A.,Kasenov M. M. Method of obtaining a subunit vaccine for the prevention of COVID-19. No. 35227 of 06.08.2021.

4. Chervyakova O. V.,Isabek A. U., Tailakova E. T.,Sadikalieva S. O.,Mukhami N. N.,Sultankulova K. T., Orynbayev M. B., Zakaria K.Recombinant plasmid DNA pET/RBD, pET/N, providing synthesis of recombinant proteins RBD (S protein binding domain receptor), N (nucleocapsid protein) of SARS-CoV-2 coronavirus, strains of Escherichia coli bacteria ER2566 — producers of recombinant corona viral proteins RBD, N, and recombinant RBD proteins (receptor binding domain of S protein), N (nucleocapsid protein) of SARS-CoV-2 coronavirus for the development of diagnostic test systems and subunit vaccines against a new coronavirus infection- COVID-19. No. 35233 dated 08/13/2021.

5. Chervyakova O. V., Sultankulova K. T., Tailakova E. T., Sadikalieva S. O., Kozhabergenov N. S., Shoraeva K. A., Orynbayev M. B., Zakarya K. D. Test systems for detection and differentiation of influenza A virus subtypes H5 and H7 by polymerase chain reaction (PCR). KZ5381-U. 18.09.2020.[8]

Awards and titles

  • Doctor of Biological Sciences (2002)
  • Professor
  • Academician
  • Badge "For merits in the development of science in Kazakhstan" (2017)
  • Medal "People's Gratitude" (Kazakhstan) (2020)
  • Letter of thanks from the President of the Republic of Kazakhstan K. Tokayev (2020)
  • Best Engineer of the Year (2020)
  • Badge "For contribution to the development of healthcare" (2021)
  • Laureate of the State Prize of the Republic of Kazakhstan in the field of science and technology named after Al-Farabi (2021)
  • Winner of the National Competition "30 zhyl 30 esim" (2021)[9]

References

  1. ↑ 1.0 1.1 "The Organization of Islamic Cooperation. Twitter".
  2. ↑ "On the establishment of the National Kurultai under the President of the Republic of Kazakhstan and the invalidation of certain decrees of the President of the Republic of Kazakhstan — The official website of the President of the Republic of Kazakhstan (In Russian)". Akorda.kz.
  3. ↑ "Patriots Forum was held in Nur-Sultan (In russian)". Главные новости столицы, страны и мира на Elorda.info. June 4, 2022.
  4. ↑ "The results of the Competition for the award of the title "Honored Inventor of the Republic of Kazakhstan-2022" have been summed up» | National Institute of Intellectual Property (In russian)". kazpatent.kz.
  5. ↑ "«ӘЙЕЛ ӘЛЕМІ». Күнсұлу Закарья ("WOMAN'S WORLD". Kunsulu Zakarya. In Kazakh)" – via www.youtube.com.
  6. ↑ "Safety and immunogenicity of a QazCovid-in® inactivated whole-virion vaccine against COVID-19 in healthy adults: A single-centre, randomised, single-blind, placebo-controlled phase 1 and an open-label phase 2 clinical trials with a 6 months follow-up in Kazakhstan.eClinicalMedicine, alongside eBioMedicine, is part of The Lancet Discovery Science".
  7. ↑ "Закарья, Кунсулу Дальтоновна (Zakarya Kunsulu from ru.wikipedia.org)". May 6, 2022 – via Wikipedia.
  8. ↑ "Закарья, Кунсулу Дальтоновна (Zakarya Kunsulu from ru.wikipedia.org)". May 6, 2022 – via Wikipedia.
  9. ↑ "Закарья, Кунсулу Дальтоновна (Zakarya Kunsulu from ru.wikipedia.org)". May 6, 2022 – via Wikipedia.

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