Yoel Sadovsky

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Yoel Sadovsky
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NationalityAmerican
Alma materHebrew University-Hadassah Medical School
OccupationPhysician-scientist

Yoel Sadovsky is a physician-scientist who studies the molecular processes underlying placental development and function, and response to injuries that impact early human development. These injuries lead to obstetrical diseases, such as fetal growth restriction, preeclampsia, and preterm birth, which predispose to neonatal, childhood, and adult diseases.

Education

Dr. Sadovsky received his MD from the Hebrew University-Hadassah Medical School in 1986 and completed his Residency in Obstetrics and Gynecology at Washington University School of Medicine in St. Louis, Missouri (1986-1990). He subsequently moved to the University of California, San Francisco, School of Medicine], where he completed a Fellowship in Maternal-Fetal Medicine and post-doctoral research training in the mechanisms of action of nuclear receptors at the Metabolic Research Unit and the Cardiovascular Research Institute. Upon returning to Washington University as an Assistant Professor in 1993, Dr. Sadovsky trained with Dr. Jeffrey Milbrandt in the area of gene regulation by orphan nuclear receptors.

Career

From 1993 to 2007, Dr. Sadovsky was a faculty member at Washington University in St. Louis, rising from the rank of his initial appointment as Assistant Professor to full tenured professor of OBGYN, and Cell Biology and Physiology in 2004. He also served as Director of the Maternal-Fetal Medicine Fellowship from 1997-2007, and Chief of the Division of Maternal-Fetal Medicine and Ultrasound from 1999-2007. In 2007 he was recruited to Pittsburgh, where he serves as the Executive and Scientific Director of Magee-Womens Research Institute at the University of Pittsburgh. He is also the Elsie Hilliard Hillman Chair of Women's Health Research, Distinguished Professor.[1] of OBGYN, with a joint appointment as Professor of Microbiology and Molecular Genetics, Vice Chair of the Dept. of OBGYN, and Associate Dean of Women’s Health Research and Reproductive Sciences.

In addition to his research, Dr. Sadovsky is engaged in training programs at the University of Pittsburgh, and in 2012, he became the director of the Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) NIH-funded research faculty training program at the University of Pittsburgh[2]. Dr. Sadovsky is an advocate for science and training in reproductive biology and women’s health research[3][4].

Research

Building on his clinical expertise in maternal-fetal medicine, Dr. Sadovsky’s NIH-funded[5] research integrates molecular and cellular biology, along with informatics tools, to decipher the differentiation of placental trophoblasts and their adaption to cellular injury. A primary focus is the function of trophoblastic non-coding RNAs, where diverse technologies are used to define the function and regulation of trophoblastic microRNA in response to injuries. MicroRNAs are also packaged in extracellular vesicles (EVs), and his lab interrogates the mechanisms of release, uptake, and function of placental EVs at the maternal-fetal interface. Another focus in the lab has been fat trafficking in the placenta, including the dynamics of lipid droplets and trophoblastic mobilization of fatty acids, as well as the function of oxidized phospholipids and trophoblast ferroptotic injury. Dr. Sadovsky’s research has contributed to over 225 published articles[6][7].

Leadership and awards

Dr. Sadovsky’s honors, awards and service include membership in the NIH’s NICHD Advisory Council (2009-2014), the NICHD Division of Intramural Research Board of Scientific Counselors (2014-2019), the NIH Advisory Committee on Research on Women’s Health (2021-2024)[8], the March of Dimes Scientific Advisory Council (2012-2018), the National Academy of Medicine (2013-present), and the Association of American Physicians (2015-present). He served as president of the Society for Reproductive Investigation (2016-2017)[9], and the Perinatal Research Society (2007-2008)[10]. From 2012-2020, he served as Editor (Americas) for the scientific journal Placenta,[11] and in 2013 he was awarded the Cozzarelli Prize in Biomedical Science from the National Academy of Sciences[12][13]

References

  1. ↑ University of Pittsburgh Distinguished Faculty https://www.provost.pitt.edu/faculty-affairs/distinguished-faculty. Retrieved November 9, 2023.
  2. ↑ Katsnelson A. Fem Fellows. PittMed Magazine, 2015;17(3):12-16. https://www.pittmed.health.pitt.edu/story/fem-fellows.
  3. ↑ Sadovsky Y, Esplin MS, Garite TJ, Nelson DM, Parry SI, Saade GR, Socol ML, Spong CY, Varner MW, D’Alton ME. Advancing research transdisciplinarity within our discipline. Am J Obstet Gynecol 2014;211:2015-7. https://pubmed.ncbi.nlm.nih.gov/24530819/
  4. ↑ Sadovsky Y, Caughey AB, DiVito M, D’Alton ME, Murtha AP, Society for Maternal-Fetal Medicine Research Committee. Research to knowledge: Promoting training of physician-scientists in the biology of pregnancy (SMFM Special Statement). Am J Obstet Gynecol 2018;281:B9-13. https://pubmed.ncbi.nlm.nih.gov/28993175/. Retrieved November 9, 2023.
  5. ↑ Dr. Sadovsky’s NIH Funded Research, National Institutes of Health (NIH) RePORTER Database, https://reporter.nih.gov/search/dCJh_M2LKEiwAmbjZONXsg/projects?shared=true. Retrieved November 9, 2023.
  6. ↑ USA National Library of Medicine PubMed bibliography of Dr. Sadovsky’s publications. https://www.ncbi.nlm.nih.gov/sites/myncbi/yoel.sadovsky.1/collections/47374913/public/.
  7. ↑ Google Scholar bibliography of Dr. Sadovsky’s publications. https://scholar.google.com/citations?user=2S1noq0AAAAJ&hl=en&oi=ao.
  8. ↑ Advisory Committee Members, National Institutes of Health Office of Research on Women’s Health. https://orwh.od.nih.gov/about/advisory-committees/advisory-committee-on-research-on-womens-health/advisory-committee-members.
  9. ↑ Society for Reproductive Investigation Presidents. https://www.sri-online.org/about-sri/history-of-sri/sri-presidents. Retrieved November 9, 2023.
  10. ↑ Perinatal Research Society Presidents. http://perinatalresearchsociety.org/about/leadership/past-officers/. Retrieved November 9, 2023.
  11. ↑ Placenta journal editorial board. https://www.sciencedirect.com/journal/placenta/about/editorial-board. Retrieved November 9, 2023.
  12. ↑ The Cozzarelli Prize. Proceedings of the National Academy of Sciences USA (PNAS). https://www.pnas.org/post/update/2013-cozzarelli-prize-recipients. Retrieved November 14, 2023.
  13. ↑ Yoel Sadovsky and Carolyn Coyne describe the placenta's role in protecting the fetus from infection by viruses. Interview: https://www.pnas.org/post/podcast/interview-2013-cozzarelli-prize-winners-yoel-sadovsky-and-carolyn-coyne. Related article: “Human placental trophoblasts confer viral resistance to recipient cells”. Proceedings of the National Academy of Sciences USA, 2013:110(29):12048-12053, https://www.pnas.org/doi/10.1073/pnas.1304718110.

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