Wei Min

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Wei Min
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Born (1981-10-01) October 1, 1981 (age 42)
Nanjing, China
NationalityChinese
CitizenshipChina
Alma mater
  • Peking University
  • Harvard University
Scientific career
Institutions
  • Columbia University

Wei Min (Chinese: 闵玮) is a Chinese-American chemist. He is currently a Professor of Chemistry at Columbia University.

Early life and education

Wei Min was born in Nanjing, China and raised in Hubei province. He graduated with a B.S. in Chemistry from Peking University in 2003. He then received his Ph.D. from Harvard University in 2008 studying Biophysics with Professor Xiaoliang Sunney Xie.

After continuing a postdoctoral position in the Xie group, Dr. Min joined the faculty of Chemistry Department at Columbia University in 2010, and was promoted to Full Professor there in 2017.

He is also affiliated with the Department of Biomedical Engineering, Kavli Institute for Brain Science, and NeuroTechnology Center at Columbia University.

Research

Min has pioneered the development of stimulated Raman scattering (SRS) microscopy and employed it to open up a broad range of applications in biophotonics. The techniques are being widely adopted by mainstream life scientists[1] as well as materials researchers[2] [3].

Stimulated Raman Scattering (SRS) Microscopy

On the technology side, together with Xiaoliang Sunney Xie and Christian Freudiger, Min co-invented the core instrumentation of SRS microscopy for biological imaging.[4] In SRS, two synchronized laser beams coherently excite the selected chemical bond, and the vibrational activation rate is amplified up to 10^8 folds, offering more than 1,000-times faster speed than the conventional Raman.[5] SRS microscope was commercialized by Leica Microsystems[6]. In 2017, Min’s group devised electronic pre-resonance (epr) SRS microscopy.[7] epr-SRS microscopy of electronically coupled vibrational modes enhances the sensitivity of the original SRS by 10,000 folds.[8] In 2019, Min’s team invented stimulated Raman excited fluorescence (SREF) spectroscopy which couples stimulated Raman excitation with fluorescence detection. With SREF microscopy, his group reported single-molecule vibrational imaging[9] and super-resolution vibrational imaging .[10]

Imaging probe development

Min’s team developed a set of tiny vibrational probes including alkynes C≡C and stable isotopes (such as 2H and 13C) for SRS imaging.[11][12][13][14][15][16] These vibrational probes are chemically inert and nearly absent inside cells, and they vibrate at unique frequencies in the cell-silent region. In addition, Min’s team designed and synthesized novel Raman-active probes which exhibits ~50 times narrower vibrational linewidth than fluorophores. These Raman-active probes have been engineered to span >20 rainbow-like colors in the cell-silent region.[17][18][19][20]

Biomedical research

These developed microscopy techniques and images probes have allowed new applications of biophotonics. When coupled with vibrational probes such as alkynes and stable isotopes (such as 2H and 13C) under SRS microscopy, small biological molecules such as nucleic acids, amino acids, peptides, fatty acids, sugars and drugs have been imaged by Min’s group with high detection specificity and sensitivity.[21][22][23][24][25][26][27][28][29][30][31] Min’s team also applied the technique to interrogate metabolism in animals. By feeding animals with heavy water or isotope-labeled glucose, they visualized metabolic dynamics such as synthesis of protein, lipid, DNA, and glycogen with high spatiotemporal resolution and molecular specificity in animals such as C. elegans, zebrafish, mice and biofilms.[32][33][34][35] By harnessing the newly developed rainbow-like Raman probes, Min’s team broken the “color barrier” of the standard fluorescence microscopy and achieved super-multiplex vibrational imaging in thin tissue slices, [36][37] organelles in live cells,[38][39] live cell profiling,[40] and volumetric imaging of thick brain tissues.[41]

Honors and awards

  • National Finalist of Blavatnik National Award for Young Scientists (2019, 2020 and 2021)
  • Pittsburgh Conference Achievement Award (2019)
  • Analyst Emerging Investigator Lectureship (2018)
  • Coblentz Award of Molecular Spectroscopy (2017)
  • ACS Early Career Award in Experimental Physical Chemistry (2017)
  • Buck-Whitney Award from ACS Eastern New York Section (2015)
  • Camille Dreyfus Teacher-Scholar Award (2015)
  • George K. Fraenkel Fund Award (2014)
  • Sloan Research Fellowship (2013)
  • National Institute of Health Director's New Innovator Award (2012)

References

  1. ↑ Hu, Fanghao; Shi, Lixue; Min, Wei (2019). "Biological Imaging of Chemical Bonds by Stimulated Raman Scattering Microscopy". Nature Methods. 16 (9): 830–842. doi:10.1038/s41592-019-0538-0. PMID 31471618.
  2. ↑ Cheng, Qian; Wei, Lu; Liu, Zhe; Ni, Nan; Sang, Zhe; Zhu, Bin; Xu, Weiheng; Chen, Meijie; Miao, Yupeng; Chen, Long-Qing; Min, Wei; Yang, Yuan (2018). "Operando and three-dimensional visualization of anion depletion and lithium growth by stimulated Raman scattering microscopy". Nature Communications. 9 (1): 2942. Bibcode:2018NatCo...9.2942C. doi:10.1038/s41467-018-05289-z. PMC 6065384. PMID 30061610.
  3. ↑ Cheng, Qian; Miao, Yupeng; Wild, Joseph; Min, Wei; Yang, Yuan (2021). "Emerging applications of stimulated Raman scattering microscopy in materials science". Matter. 4 (5): 1460–1483. doi:10.1016/j.matt.2021.02.013.
  4. ↑ Freudiger, Christian W.; Min, Wei; Saar, Brian G.; Lu, Sijia; Holtom, Gary R.; He, Chengwei; Tsai, Jason C.; Kang, Jing X.; Xie, X. Sunney (2008). "Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy". Science. 322 (5909): 1857–1861. Bibcode:2008Sci...322.1857F. doi:10.1126/science.1165758. PMC 3576036. PMID 19095943.
  5. ↑ Min, Wei; Freudiger, Christian W.; Lu, Sijia; Xie, X. Sunney (2011). "Coherent Nonlinear Optical Imaging: Beyond Fluorescence Microscopy". Annual Review of Physical Chemistry. 62: 507–530. Bibcode:2011ARPC...62..507M. doi:10.1146/annurev.physchem.012809.103512. PMC 3427791. PMID 21453061.
  6. ↑ "Coherent Raman Scattering Microscope STELLARIS 8 CRS".
  7. ↑ Wei, Lu; Chen, Zhixing; Shi, Lixue; Long, Rong; Anzalone, Andrew V.; Zhang, Luyuan; Hu, Fanghao; Yuste, Rafael; Cornish, Virginia W.; Min, Wei (2017). "Super-multiplex vibrational imaging". Nature. 544 (7651): 465–470. Bibcode:2017Natur.544..465W. doi:10.1038/nature22051. PMC 5939925. PMID 28424513.
  8. ↑ Wei, Lu; Min, Wei (2018). "Electronic Preresonance Stimulated Raman Scattering Microscopy". J. Phys. Chem. Lett. 9 (15): 4294–4301. doi:10.1021/acs.jpclett.8b00204. PMC 6077771. PMID 30001137.
  9. ↑ Xiong, Hanqing; Shi, Lixue; Wei, Lu; Shen, Yihui; Long, Rong; Zhao, Zhilun; Min, Wei (2019). "Stimulated Raman excited fluorescence spectroscopy and imaging". Nature Photonics. 13 (6): 412–417. Bibcode:2019NaPho..13..412X. doi:10.1038/s41566-019-0396-4. PMC 7326316. PMID 32607124.
  10. ↑ Xiong, Hanqing; Qian, Naixin; Miao, Yupeng; Zhao, Zhilun; Chen, Chen; Min, Wei (2021). "Super-resolution vibrational microscopy by stimulated Raman excited fluorescence". Light: Science & Applications. 10 (1): 87. Bibcode:2021LSA....10...87X. doi:10.1038/s41377-021-00518-5. PMC 8058038. PMID 33879766.
  11. ↑ Wei, L.; Yu, Y.; Shen, Y.; Wang, M. C.; Min, W. (2013). "Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy". Proceedings of the National Academy of Sciences. 110 (28): 11226–11231. Bibcode:2013PNAS..11011226W. doi:10.1073/pnas.1303768110. PMC 3710790. PMID 23798434.
  12. ↑ Wei, Lu; Hu, Fanghao; Shen, Yihui; Chen, Zhixing; Yu, Yong; Lin, Chih-Chun; Wang, Meng C.; Min, Wei (2014). "Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering". Nature Methods. 11 (4): 410–412. doi:10.1038/nmeth.2878. PMC 4040164. PMID 24584195.
  13. ↑ Chen, Zhixing; Paley, Daniel W.; Wei, Lu; Weisman, Andrew L.; Friesner, Richard A.; Nuckolls, Colin; Min, Wei (2014). "Multicolor Live-Cell Chemical Imaging by Isotopically Edited Alkyne Vibrational Palette". J. Am. Chem. Soc. 136 (22): 8027–8033. doi:10.1021/ja502706q. PMC 4063185. PMID 24849912.
  14. ↑ Wei, Lu; Shen, Yihui; Xu, Fang; Hu, Fanghao; Harrington, Jamie K.; Targoff, Kimara L.; Min, Wei (2015). "Imaging Complex Protein Metabolism in Live Organisms by Stimulated Raman Scattering Microscopy with Isotope Labeling". ACS Chem. Biol. 10 (3): 901–908. doi:10.1021/cb500787b. PMC 4610303. PMID 25560305.
  15. ↑ Hu, Fanghao; Chen, Zhixing; Zhang, Luyuan; Shen, Yihui; Wei, Lu; Min, Wei (2015). "Vibrational Imaging of Glucose Uptake Activity in Live Cells and Tissues by Stimulated Raman Scattering". Angewandte Chemie International Edition. 54 (34): 9821–9825. doi:10.1002/anie.201502543. PMC 4644272. PMID 26207979.
  16. ↑ Wei, Lu; Hu, Fanghao; Chen, Zhixing; Shen, Yihui; Zhang, Luyuan; Min, Wei (2016). "Live-Cell Bioorthogonal Chemical Imaging: Stimulated Raman Scattering Microscopy of Vibrational Probes". Accounts. 49 (8): 1494–1502. doi:10.1021/acs.accounts.6b00210. PMC 5704954. PMID 27486796.
  17. ↑ Wei, Lu; Chen, Zhixing; Shi, Lixue; Long, Rong; Anzalone, Andrew V.; Zhang, Luyuan; Hu, Fanghao; Yuste, Rafael; Cornish, Virginia W.; Min, Wei (2017). "Super-multiplex vibrational imaging". Nature. 544 (7651): 465–470. Bibcode:2017Natur.544..465W. doi:10.1038/nature22051. PMC 5939925. PMID 28424513.
  18. ↑ Hu, Fanghao; Zeng, Chen; Long, Rong; Miao, Yupeng; Wei, Lu; Xu, Qizhi; Min, Wei (2018). "Supermultiplexed optical imaging and barcoding with engineered polyynes". Nature Methods. 15 (3): 194–200. doi:10.1038/nmeth.4578. PMC 5831481. PMID 29334378.
  19. ↑ Zhao, Zhilun; Chen, Chen; Wei, Shixuan; Xiong, Hanqing; Hu, Fanghao; Miao, Yupeng; Jin, Tianwei; Min, Wei (2021). "Ultra-bright Raman dots for multiplexed optical imaging". Nature Communications. 12 (1): 1305. Bibcode:2021NatCo..12.1305Z. doi:10.1038/s41467-021-21570-0. PMC 7910594. PMID 33637723.
  20. ↑ Miao, Yupeng; Qian, Naixin; Shi, Lixue; Hu, Fanghao; Min, Wei (2021). "9-Cyanopyronin probe palette for super-multiplexed vibrational imaging". Nature Communications. 12 (1): 4518. Bibcode:2021NatCo..12.4518M. doi:10.1038/s41467-021-24855-6. PMC 8313527. PMID 34312393.
  21. ↑ Wei, L.; Yu, Y.; Shen, Y.; Wang, M. C.; Min, W. (2013). "Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy". PNAS. 110 (28): 11226–11231. Bibcode:2013PNAS..11011226W. doi:10.1073/pnas.1303768110. PMC 3710790. PMID 23798434.
  22. ↑ Wei, Lu; Hu, Fanghao; Shen, Yihui; Chen, Zhixing; Yu, Yong; Lin, Chih-Chun; Wang, Meng C.; Min, Wei (2014). "Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering". Nature Methods. 11 (4): 410–412. doi:10.1038/nmeth.2878. PMC 4040164. PMID 24584195.
  23. ↑ Chen, Zhixing; Paley, Daniel W.; Wei, Lu; Weisman, Andrew L.; Friesner, Richard A.; Nuckolls, Colin; Min, Wei (2014). "Multicolor Live-Cell Chemical Imaging by Isotopically Edited Alkyne Vibrational Palette". J. Am. Chem. Soc. 136 (22): 8027–8033. doi:10.1021/ja502706q. PMC 4063185. PMID 24849912.
  24. ↑ Shen, Yihui; Xu, Fang; Wei, Lu; Hu, Fanghao; Min, Wei (2014). "Live-Cell Quantitative Imaging of Proteome Degradation by Stimulated Raman Scattering". Angewandte Chemie International Edition. 53 (22): 5596–5599. doi:10.1002/anie.201310725. PMC 4231775. PMID 24737659.
  25. ↑ Wei, Lu; Shen, Yihui; Xu, Fang; Hu, Fanghao; Harrington, Jamie K.; Targoff, Kimara L.; Min, Wei (2015). "Imaging Complex Protein Metabolism in Live Organisms by Stimulated Raman Scattering Microscopy with Isotope Labeling". ACS Chem. Biol. 10 (3): 901–908. doi:10.1021/cb500787b. PMC 4610303. PMID 25560305.
  26. ↑ Hu, Fanghao; Chen, Zhixing; Zhang, Luyuan; Shen, Yihui; Wei, Lu; Min, Wei (2015). "Vibrational Imaging of Glucose Uptake Activity in Live Cells and Tissues by Stimulated Raman Scattering". Angewandte Chemie International Edition. 54 (34): 9821–9825. doi:10.1002/anie.201502543. PMC 4644272. PMID 26207979.
  27. ↑ Wei, Lu; Hu, Fanghao; Chen, Zhixing; Shen, Yihui; Zhang, Luyuan; Min, Wei (2016). "Live-Cell Bioorthogonal Chemical Imaging: Stimulated Raman Scattering Microscopy of Vibrational Probes". Acc. Chem. Res. 49 (8): 1494–1502. doi:10.1021/acs.accounts.6b00210. PMC 5704954. PMID 27486796.
  28. ↑ Zhao, Zhilun; Shen, Yihui; Hu, Fanghao; Min, Wei (2017). "Applications of vibrational tags in biological imaging by Raman microscopy". Analyst. 142 (21): 4018–4029. Bibcode:2017Ana...142.4018Z. doi:10.1039/C7AN01001J. PMC 5674523. PMID 28875184.
  29. ↑ Shen, Yihui; Zhao, Zhilun; Zhang, Luyuan; Shi, Lingyan; Shahriar, Sanjid; Chan, Robin B.; Di Paolo, Gilbert; Min, Wei (2017). "Metabolic activity induces membrane phase separation in endoplasmic reticulum". PNAS. 114 (51): 13394–13399. doi:10.1073/pnas.1712555114. PMC 5754785. PMID 29196526.
  30. ↑ Gaschler, Michael M.; Hu, Fanghao; Feng, Huizhong; Linkermann, Andreas; Min, Wei; Stockwell, Brent R. (2018). "Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis". ACS Chemical Biology. 13 (4): 1013–1020. doi:10.1021/acschembio.8b00199. PMC 5960802. PMID 29512999.
  31. ↑ Shen, Yihui; Hu, Fanghao; Min, Wei (2019). "Raman Imaging of Small Biomolecules". Annual Review of Biophysics. 48: 347–369. doi:10.1146/annurev-biophys-052118-115500. PMID 30892920.
  32. ↑ Shi, Lingyan; Zheng, Chaogu; Shen, Yihui; Chen, Zhixing; Silveira, Edilson S.; Zhang, Luyuan; Wei, Mian; Liu, Chang; De Sena-Tomas, Carmen; Targoff, Kimara; Min, Wei (2018). "Optical Imaging of Metabolic Dynamics in Animals". Nature Communications. 9 (1): 2995. Bibcode:2018NatCo...9.2995S. doi:10.1038/s41467-018-05401-3. PMC 6079036. PMID 30082908.
  33. ↑ Zhang, L.; Shi, L.; Shen, Y.; Miao, Y.; Wei, M.; Qian, N.; Liu, Y.; Min, W. (2019). "Spectral tracing of isotope deuterium (STRIDE) for imaging glucose metabolism". Nature Biomedical Engineering. 3 (5): 402–413. doi:10.1038/s41551-019-0393-4. PMC 6599680. PMID 31036888.
  34. ↑ Wei, Mian; Shi, Lingyan; Shen, Yihui; Zhao, Zhilun; Guzman, Asja; Kaufman, Laura J.; Wei, Lu; Min, Wei (2019). "Volumetric Chemical Imaging by Clearing-Enhanced Stimulated Raman Scattering Microscopy". PNAS. 116 (14): 6608–6617. doi:10.1073/pnas.1813044116. PMC 6452712. PMID 30872474.
  35. ↑ Schiessl, Konstanze T.; Hu, Fanghao; Jo, Jeanyoung; Nazia, Sakila Z.; Wang, Bryan; Price-Whelan, Alexa; Min, Wei; Dietrich, Lars E. P. (2019). "Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms". Nature Communications. 10 (1): 762. Bibcode:2019NatCo..10..762S. doi:10.1038/s41467-019-08733-w. PMC 6377615. PMID 30770834.
  36. ↑ Wei, Lu; Chen, Zhixing; Shi, Lixue; Long, Rong; Anzalone, Andrew V.; Zhang, Luyuan; Hu, Fanghao; Yuste, Rafael; Cornish, Virginia W.; Min, Wei (2017). "Super-multiplex vibrational imaging". Nature. 544 (7651): 465–470. Bibcode:2017Natur.544..465W. doi:10.1038/nature22051. PMC 5939925. PMID 28424513.
  37. ↑ Zhao, Zhilun; Chen, Chen; Wei, Shixuan; Xiong, Hanqing; Hu, Fanghao; Miao, Yupeng; Jin, Tianwei; Min, Wei (2021). "Ultra-bright Raman dots for multiplexed optical imaging". Nature Communications. 12 (1): 1305. Bibcode:2021NatCo..12.1305Z. doi:10.1038/s41467-021-21570-0. PMC 7910594. PMID 33637723.
  38. ↑ Hu, Fanghao; Zeng, Chen; Long, Rong; Miao, Yupeng; Wei, Lu; Xu, Qizhi; Min, Wei (2018). "Supermultiplexed optical imaging and barcoding with engineered polyynes". Nature Methods. 15 (3): 194–200. doi:10.1038/nmeth.4578. PMC 5831481. PMID 29334378.
  39. ↑ Shou, Jingwen; Oda, Robert; Hu, Fanghao; Karasawa, Keiko; Nuriya, Mutsuo; Yasui, Masato; Shiramizu, Bruce; Min, Wei; Ozeki, Yasuyuki (2021). "Super-multiplex imaging of cellular dynamics and heterogeneity by integrated stimulated Raman and fluorescence microscopy". iScience. 24 (8): 102832. doi:10.1016/j.isci.2021.102832. PMC 8333161. PMID 34381966.
  40. ↑ Chen, Chen; Zhao, Zhilun; Qian, Naixin; Wei, Shixuan; Hu, Fanghao; Min, Wei (2021). "Multiplexed live-cell profiling with Raman probes". Nature Communications. 12 (1): 3405. Bibcode:2021NatCo..12.3405C. doi:10.1038/s41467-021-23700-0. PMC 8184955. PMID 34099708.
  41. ↑ "Highly-multiplexed volumetric mapping with Raman dye imaging and tissue clearing". Nature Biotechnology. doi:10.1038/s41587-021-01041-z (inactive 2021-09-02).{{cite journal}}: CS1 maint: DOI inactive as of September 2021 (link)

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