Scott D. Tanner

Scott D. Tanner is a Canadian scientist and is one of the original co-inventors of Mass cytometry technology.

Dr. Tanner co-founded DVS Sciences in 2004 (acquired by Fluidigm in 2014 and then renamed to Standard BioTools in 2022) along with Dmitry Bandura,Vladimir Baranov and Olga Ornatsky.

Early Life and Education

• Scott grew up in St. Catharines, Ontario Canada. At age six he purchased his first chemistry set from his brother.

• At Brock University, under the auspices of Dr. E.A. Cherniak and Dr. F.P. Koffyberg, Scott experimented with cloud chambers.

• At York University, Scott became a nationally ranked gymnast.

• Scott ran six marathons between 1978 and 1981 – his best time was 2:47:13.

• B Sc Chemistry York University – 1976

• Doctor of Philosophy Chemistry York University– 1980

Biography

Dr. Tanner was Principal Scientist with MDS SCIEX, the analytical technologies division of MDS Inc. In his 25 years at SCIEX, Dr. Tanner developed and helped to commercialize a string of Mass Spectrometry products. Scott published over 74 peer-reviewed scientific articles, and holds 22 US patents (with corresponding filings in other countries), including 13 patents on Mass Cytometry technology.

Scott was a co-founder of DVS Sciences and, as the President and CEO, saw the company through the development and commercial launch of its first products.

The products that DVS Sciences brought to the global market were originally developed at the University of Toronto where Dr. Tanner was a Professor in the Institute of Biomaterials and Biomedical Engineering and then in Chemistry.

Career

• Principal Scientist SCIEX - 1980-2005

• President DVS Sciences 2004 - 2015
  (acquired by Fluidigm in 2014)
  

Books

• 2001 Plasma Source Mass Spectrometry: The New Millennium ISBN-10: ‎0854048952 ISBN-13‏: ‎978-0854048953

• 2003 Plasma Source Mass Spectrometry: Applications and Emerging Technologies ISBN: 978-0-85404-603-4

Research

• Development of the DRC Collision/reaction cell

• Mass cytometry (CyTOF)

Awards and honors

• 2020 Lifetime Achievement Award in Plasma Spectrochemistry

• 2019 HUPO Award (Human Proteome Organization)

• 2014 Fellow of the American Institute for Medical and Biological Engineering

• 2011 University of Toronto Inventor of the Year Award for Biomedical and Life Sciences

• 2011 Thermo Fisher Scientific Spectroscopy Award

• 2003 W.A.E. McBryde medal from the Canadian Chemical Society of the Chemical Institute of Canada

• 2002 Elsevier Award SAB

• 2001 Manning Innovation Foundation Award of Distinction Dr. Scott Tanner, together with Dr. Vladimir Baranov, received the Manning Award of Distinction from the Manning Innovation Awards foundation for the remarkable invention of the ICP-MS Dynamic Reaction Cell (Collision/reaction cell).

• Fellow of the Royal Society of Chemistry (UK)

Publications

• Jan 2015 Single-Cell Mass Cytometry Reveals Intracellular Survival/Proliferative Signaling in FLT3-ITD-Mutated AML Stem/Progenitor Cells

• Aug 2014 Metal-chelating polymers developed for mass cytometry as a potential route to high activity radioimmunotherapeutic agents

• July 2014 Single cell measurement of the uptake, intratumoral distribution, and cell cycle effects of cisplatin using mass cytometry

• May 2013 The Means: Cytometry and Mass Spectrometry Converge in a Single Cell Deep Profiling Platform

• April 2013 An introduction to mass cytometry: Fundamentals and applications

• July 2012 Human CD4+ lymphocytes for antigen quantification: Characterization using conventional flow cytometry and mass cytometry

• Nov 2011 MASSIVELY MULTIPARAMETER SINGLE CELL ANALYSIS BY MASS CYTOMETRY

• May 2011 Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

• Feb 2011 Hydrocarbon ions in fuel-rich, CH4–C2H2–O2 flames as a probe for the initiation of soot: interpretation of the ion chemistry

• Feb 2011 A room-temperature study of the kinetics of protonation of formaldehyde

• Feb 2011 Hydrocarbon ions in fuel-rich, CH4–C2H2–O2 flames as a probe for the initiation of soot: an experimental approach

• Feb 2011 An experimental study of the reactivity of the hydroxide anion in the gas phase at room temperature, and its perturbation by hydration

• Feb 2011 Gas-phase proton-transfer reactions of the hydronium ion at 298 K

• Sept 2010 Highly multiparametric analysis by mass cytometry

• Feb 2010 Metal-Containing Polystyrene Beads as Standards for Mass Cytometry

• July 2009 Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-of-Flight Mass Spectrometry

• Mar 2009 ICP-MS Applications

• Dec 2008 Flow cytometer with mass spectrometer detection for massively multiplexed single-cell biomarker assay

• Aug 2008 Element-tagged immunoassay with ICP-MS detection: Evaluation and comparison to conventional immunoassays

• May 2008 Study of Cell Antigens and Intracellular DNA by Identification of Element-Containing Labels and Metallointercalators Using Inductively Coupled Plasma Mass Spectrometry

• Feb 2008 Development of analytical methods for multiplex bio-assay with inductively coupled plasma mass spectrometry

• Oct 2007 Determination of Fe, Ni, Co, Cu and Zn in high-Ca samples using methane as a reaction cell gas

• Sept 2007 A novel chemical reactor suited for studies of biophysical chemistry: Construction and evaluation of a selected ion flow tube utilizing an electrospray ion source and a triple quadrupole detection system

• Mar 2007 Multiplex bio-assay with inductively coupled plasma mass spectrometry: Towards a massively multivariate single-cell technology

• Jan 2007 Reaction chemistry and collisional processes in multipole devices

• Sept 2006 Messenger RNA Detection in Leukemia Cell lines by Novel Metal-Tagged in situ Hybridization using Inductively Coupled Plasma Mass Spectrometry

• Sept 2006 Gas-phase ion–molecule reactions for resolution of atomic isobars: AMS and ICP-MS perspectives

• Mar 2006 Multiplex Biomarker Detection by ICP‐MS

• Feb 2006 Multiple cellular antigen detection by ICP-MS

• Dec 2005 Limitations of the effective potential for the evaluation of the ion energy in the RF-driven quadrupole field

• Jul 2004 Chemical Resolution of Pu + from U + and Am + Using a Band-Pass Reaction Cell Inductively Coupled Plasma Mass Spectrometer

• Jan 2003 New challenges for ICP-MS instrumentation and data acquisition. Solving problems of real life biology

• Oct 2002 Inductively coupled plasma mass spectrometer with axial field in a quadrupole reaction cell

• Sept 2002 The potential for elemental analysis in biotechnology

• Sept 2002 Reaction cells and collision cells for ICP-MS: A tutorial review

• Aug 2002 Simultaneous determination of proteins using an element-tagged immunoassay coupled with ICP-MS detection

• May 2002 Detection of Ultratrace Phosphorus and Sulfur by Quadrupole ICPMS with Dynamic Reaction Cell

• May 2002 A Sensitive and Quantitative Element-Tagged Immunoassay with ICPMS Detection

• Sept 2001 Elimination of isobaric interferences in ICP-MS, using ion?molecule reaction chemistry: Rb/Sr age determination of magmatic rocks, a case study

• July 2001 Reaction chemistry and collisional processes in multiple devices for resolving isobaric interferences in ICP-MS

• Sept 2000 Inductively coupled plasma/selected-ion flow tube mass spectrometric study of the chemical resolution of isobaric interferences

• Sept 2000 A dynamic reaction cell for inductively coupled plasma mass spectrometry (ICP-DRC-MS) - Part III

• Jan 2000 Effect of collisional damping and reactions in a dynamic reaction cell on the precision of isotope ratio measurements

• Jan 2000 A novel inductively coupled plasma/selected-ion flow tube mass spectrometer for the study of reactions of atomic and atomic oxide ions

• Nov 1999 A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). II. Reduction of Interferences Produced Within the Cell

• Mar 1999 Theory, Design, and Operation of a Dynamic Reaction Cell for ICPMS

• Mar 1999 Effect of Collisional Damping in the Dynamic Reaction Cell on the Precision of Isotope Ratio Measurements

• Jan 1999 A dynamic reaction cell for inductively coupled plasma mass spectrometry (ICP-DRC-MS)

• April 1980 An experimental study of nucleophilic addition to formaldehyde in the gas phase

• Oct 1979 ChemInform Abstract: AN EXPERIMENTAL STUDY OF THE GAS-PHASE KINETICS OF REACTIONS WITH HYDRATED HYDRONIUM(1+) IONS(N = 1-3) AT 298 K

• July 1979 An experimental study of the gas-phase kinetics of reactions with hydrated H3O+ ions (n = 1-3) at 298 K

• Feb 1979 Proton transfer reactions of HCO+ at 298 K

• Systems immunology (WS-086) WS/PP-086-01 What is “Systems Immunology” for? WS/PP-086-02 Cholinergic stimulation modulates T cell-independent humoral immune responses in the spleenWS/PP-086-03 Next-generation 31-parameter flow cytometry reveals systems-level relationships in human bone marrow signaling and homeostasisWS/PP-086-04 Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics of antigen microarray dataWS/PP-086-05 Methods for develo

• Systems immunology (WS-086) WS/PP-086-01 What is “Systems Immunology” for? WS/PP-086-02 Cholinergic stimulation modulates T cell-independent humoral immune responses in the spleenWS/PP-086-03 Next-generation 31-parameter flow cytometry reveals systems-level relationships in human bone marrow signaling and homeostasisWS/PP-086-04 Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics of antigen microarray dataWS/PP-086-05 Methods for de

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