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Pittsburgh, the county seat of Allegheny County in Pennsylvania, is the state's largest metropolis. It is Pennsylvania's second-largest city, behind Philadelphia, and the 68th-largest city in the United States. With a population of 2.37 million, Pittsburgh's metropolitan area is the biggest in both the Ohio Valley and Appalachia, and the second-largest in Pennsylvania. The city has a population of 302,971 people as of the most recent census in 2020.

Allegheny River and Monongahela River meet to create the Ohio river in southwest Pennsylvania's Pittsburgh area. In addition to its 446 bridges, Pittsburgh is renowned as the "Steel City" for its more than 300 steel-related enterprises. At the junction of the two rivers, the city's Point State Park is home to 30 skyscrapers, two inclined trains, a pre-revolutionary fortress, and a number of other attractions. Due to its mineral-rich location, Pittsburgh became an important connection between the Atlantic coasts and the Midwest throughout the colonial period and the American Civil War because of its proximity to the Allegheny Mountains.

In addition to steel, Pittsburgh has been a leader in the production of aluminium and glass, and in the petroleum sector. In addition, it is a leader in the fields of computers, electronics, and automobiles. Pittsburgh was the third-largest city in the United States in terms of corporate headquarters employment in the early 20th century, after only New York City and Chicago. It also had the most U.S. shareholders per capita. Steel and other heavy industries decreased in the 1970s and 1980s, and thousands of downtown white-collar employees were also laid off when numerous Pittsburgh-based corporations relocated. In 1950, the population was 675,000, and by 1990, it had fallen to 370,000. As a result of the city's long industrial heritage, world-class museums, hospitals, green spaces, and research institutes have sprung up across the downtown area.

After 1990, Pittsburgh became a centre for the health care, education, and technology sectors in the United States. Pittsburgh has 68 colleges and universities, including Carnegie Mellon University and the University of Pittsburgh, as well as prominent medical institutions, such as the University of Pittsburgh Medical Center (UPMC). More than 1,600 Pittsburgh-based technology companies, including Google, Apple, Bosch, Facebook, Uber, Nokia, Autodesk, Amazon, Microsoft, and IBM, generate $20.7 billion in yearly payrolls.