Philippe Soriano

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Philippe Soriano
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CitizenshipUnited States of America
Alma materUniversity of Paris
OccupationDevelopmental biologist
Years active1987-present
AwardsMERIT award from the National Institutes of Health (2002)

Philippe Soriano is a developmental biologist who currently is a Professor of Cell, Developmental, and Regenerative Biology at the Icahn School of Medicine at Mount Sinai in New York City. Soriano is well known for his work on cell signaling during embryonic development. He has also developed numerous tools that have been very useful in the field of mouse genetics.


Soriano grew up in New York City but moved to France when he was eighteen. He did his undergraduate and graduate degrees at the University of Paris, from which he received his doctorate in 1982.[1]

Career and research

Soriano carried out his graduate work at the Institut Jacques Monod with Giorgio Bernardi working on isochores and compositional organization of the mammalian genome. He did postdoctoral work with Rudolf Jaenisch, initially in Hamburg, Germany and then at the Whitehead Institute for Biomedical Research, where he used retroviruses as lineage tags in early development and as insertional mutagens.

His first faculty appointment in 1987 was at Baylor College of Medicine where he conducted the first genetic analysis of Src family kinases[2] through gene knockouts and developed gene trapping[3] methods. One of the gene trap lines was an insertion at the ROSA26 locus[4], which expressed a reporter in all tissues and proved useful for chimera analysis. He then moved to the Fred Hutchinson Cancer Research Center, where he began to work on signaling specificity engaged by growth factor receptors, particularly PDGF[5][6][7][8] and FGF[9]. He also developed methods for targeting the ROSA26 locus, by generating one of the first reporter mice for Cre recombinase[10]. This locus has since been used as a primary docking site in the mouse genetics community for generalized gene expression[11]. He moved to the Icahn School of Medicine at Mount Sinai in 2008 where he has continued to work on cell signaling pathways[12], particularly in the context of the early embryo, and in the neural crest and craniofacial development.

Awards and honors

  • Howard Hughes Medical Institute Investigator (1987)[13]
  • Pew Scholar in the Biomedical Sciences from the Pew Charitable Trusts[14] (1988)
  • MERIT award from the National Institutes of Health (2002)
  • Edwin G. Conklin Medal from the Society for Developmental Biology[15] (2017)


In the media


  2. Soriano, P; Montgomery, C; Geske, R; Bradley, A (1991). "Targeted disruption of the c-src proto- oncogene leads to osteopetrosis in mice". Cell. 64: 693-702. PMID 1997203.
  3. Friedrich, G; Soriano, P (1991). "Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice". Genes & Development. 5: 1513-1523. PMID 1653172.
  4. Zambrowicz, BP; Imamoto, A; Fiering, S; Herzenberg, LA; Kerr, WG; Soriano, P (1997). "Disruption of overlapping transcripts in the ROSAbgeo 26 gene trap strain leads to widespread expression of b". Proc. Natl. Acad. Sci. USA. 94: 3789-3794. PMID 9108056.
  5. Soriano, P (1994). "Abnormal kidney development and hematological disorders in PDGFb receptor mutant mice". Genes & Development. 8: 1888-1896. PMID 7958864.
  6. Soriano, P (1997). "The PDGFa Receptor is required for neural crest cell development and for normal patterning of the somites". Development. 124: 2691-2700. PMID 9226440.
  7. Klinghoffer, RA; Hamilton, TG; Hoch, R; Soriano, P (2002). "An allelic series at the PDGFaR locus indicates unequal contributions of distinct signaling pathways during development". Developmental Cell. 2: 103-113. PMID 11782318.
  8. Tallquist, MD; French, WJ; Soriano, P (2003). "Additive effects of PDGF receptor b signaling pathways in vascular smooth muscle cell development". PLoS Biology. 1: 288-299. PMID 14624252.
  9. Brewer, JR; Molotkov, A; Mazot, P; Hoch, RV; Soriano, P (2015). "Fgfr1 regulates development through the combinatorial use of signaling proteins". Genes & Development. 29: 1863-1874. PMID 26341559.
  10. Soriano, P (1999). "Generalized lacZ expression with the ROSA26 Cre reporter strain". Nature Genetics. 21: 70-71. PMID 9916792.
  12. Vasudevan, HN; Mazot, P; He, F; Soriano, P (2015). "Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways". eLife. 4: 10.7554/eLife.07186. PMID 25951516.

External links

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