Pawel Michalak
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Pawel Michalak | |
|---|---|
| Born | May 24, 1969 Łódź, Poland |
| Alma mater | University of Łódź (MSc), Jagiellonian University (PhD) |
| Known for | Comparative genomics, Molecular evolution, Host-pathogen interactions |
| Scientific career | |
| Fields | Evolutionary genetics, Genomics, Bioinformatics |
| Institutions | Edward Via College of Osteopathic Medicine |
Pawel Michalak (born 24 May 1969) is an evolutionary geneticist and professor at Edward Via College of Osteopathic Medicine (VCOM), where he serves as Associate Dean for Biomedical Affairs and Research. He holds an adjunct research appointment at the Institute of Evolution at the University of Haifa, Israel.
Michalak's research integrates molecular biology, computational modeling, and next-generation sequencing to explore evolutionary complexity, genome-environment interactions, and host-pathogen co-evolution. He founded the Integrative Genome Analysis Lab, which transitioned from Virginia Tech's Bioinformatics Institute to VCOM’s Center for One Health Research.
His research topics include interspecies hybrid incompatibilities.[1] , nucleolar dominance, cancer genetics, meiotic recombination, adaptive stress resistance, non-coding RNAs, and host-pathogen coevolution. He has contributed to genome projects for species including the tuatara[2], Komodo dragon, and bowhead whale, and has studied evolutionary adaptation in Drosophila ("Evolution Canyon" on Mount Carmel)[3][4][5][6][7][8]. His SARS-CoV-2 research published in Cell[9] received broad media attention[10][11]. In 2024, his commentary in BioScience critically assessed claims of rediscovery of the Ivory-billed Woodpecker[12]
References
- ↑ Malone, John H.; Michalak, Pawel (January 4, 2008). "Physiological sex predicts hybrid sterility regardless of genotype" (PDF). Science. 319 (5850): 72–75. Bibcode:2008Sci...319...59M. doi:10.1126/science.1148231. ISSN 0036-8075. PMID 18174436.
- ↑ Gemmell, Neil J.; Rutherford, Kim; Prost, Stefan; Tollis, Marc; Winter, David; Macey, J. Robert; Adelson, David L. (2020). "The tuatara genome reveals ancient features of amniote evolution". Nature. 584 (7821): 403–409. doi:10.1038/s41586-020-2561-9. PMC 7116210. PMID 32760000. Full text (PDF)
- ↑ "DNA of 'Evolution Canyon' fruit flies reveals drivers of evolutionary change". EurekAlert!. American Association for the Advancement of Science. 15 June 2021.
- ↑ Korol, Abraham; Rashkovetsky, Eugenia; Iliadi, Konstantin; Michalak, Pawel; Ronin, Yefim; Nevo, Eviatar (2000). "Nonrandom mating in Drosophila melanogaster laboratory populations derived from closely adjacent ecologically contrasting slopes at "Evolution Canyon"". Proceedings of the National Academy of Sciences. 97 (23): 12637–12642. doi:10.1073/pnas.220041397. PMC 18816. PMID 11050149. Full text (PDF)
- ↑ Kim, Young Bun; Oh, Jung Hun; McIver, Lauren J.; Rashkovetsky, Eugenia; Michalak, Katarzyna; Garner, Harold R.; Kang, Lin; Nevo, Eviatar; Korol, Abraham B.; Michalak, Pawel (2014). "Divergence of Drosophila melanogaster repeatomes in response to a sharp microclimate contrast in Evolution Canyon, Israel". Proceedings of the National Academy of Sciences. 111 (29): 10630–10635. Bibcode:2014PNAS..11110630K. doi:10.1073/pnas.1410372111. PMC 4115526. PMID 25006263. Full text (PDF)
- ↑ Michalak, Pawel; Minkov, Irina; Helin, Amanda; Lerman, Daniel N.; Bettencourt, Brian R.; Feder, Martin E.; Korol, Abraham B.; Nevo, Eviatar (2001). "Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in "Evolution Canyon," Israel". Proceedings of the National Academy of Sciences. 98 (23): 13195–13200. Bibcode:2001PNAS...9813195M. doi:10.1073/pnas.231478298. PMC 60847. PMID 11687637. Full text (PDF)
- ↑ Kang, Lin; Rashkovetsky, Eugenia; Michalak, Katarzyna; Garner, Harold R.; Mahaney, James E.; Rzigalinski, Beverly A.; Korol, Abraham; Nevo, Eviatar; Michalak, Pawel (2019). "Genomic divergence and adaptive convergence in Drosophila simulans from Evolution Canyon, Israel". Proceedings of the National Academy of Sciences. 116 (24): 11839–11844. Bibcode:2019PNAS..11611839K. doi:10.1073/pnas.1720938116. PMC 6576144. PMID 31127048. Full text (PDF)
- ↑ Yablonovitch, Arielle L.; Fu, Jeremy; Li, Kexin; Mahato, Simpla; Kang, Lin; Rashkovetsky, Eugenia; Korol, Abraham B. (2017). "Regulation of gene expression and RNA editing in Drosophila adapting to divergent microclimates". Nature Communications. 8 (1): 1570. Bibcode:2017NatCo...8.1570Y. doi:10.1038/s41467-017-01658-2. PMC 5691062. PMID 29146998. Full text (PDF)
- ↑ Kang, Lin; He, Guijuan; Sharp, Amanda K.; Wang, Xiaofeng; Brown, Anne M.; Michalak, Pawel; Weger-Lucarelli, James (2021). "A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation". Cell. 184 (17): 4392–4400.e4. doi:10.1016/j.cell.2021.07.007. PMC 8260498. PMID 34289344. Full text (PDF)
- ↑ McKay, Betsy (1 March 2021). "COVID-19 Virus Studies Yield New Clues on Pandemic's Origin". The Wall Street Journal.
- ↑ Elde, Nels; Racaniello, Vincent (9 April 2021). "TWiEVO 65: Viral evolution and adaptation". This Week in Evolution. Microbe.tv.
- ↑ Michalak, Pawel (2024). "Echo of extinction: The Ivory-billed Woodpecker's tragic legacy and its impact on scientific integrity". BioScience. 74 (11): 740–746. doi:10.1093/biosci/biae072. Full text (PDF)
External links
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