Nels Andrew Olson

Nels Andrew Olson
Born	(1960-10-17) 17 October 1960 Portland, Oregon, USA
Education	Ph.D., Analytical Chemistry, University of Washington, BA. Biochemistry, Reed College
Alma mater	University of Washington
Spouse(s)	Nataliya Olson
Children	Constantine Nestor Olson
Awards	Two time Engineering Team of the Year Member at The Boeing Company; Engineering Excellence Award, The Boeing Company, 2019; Fulbright Fellow, Royal Institute of Technology, Sweden; Five-time A.W. 'Winn' Brindle Scholar; Two-time ARCO graduate research fellow; Three-time Boeing graduate research fellow; Washington Technology Center Governor’s Research Award
Scientific career
Fields	chemistry
Institutions	Molecular Probes Inc.; University of Washington; Royal Institute of Technology; Library of Congress; Molecular Dynamics.; Illumina Inc.; Johns Hopkins University; Defense Threat Reduction Agency; the Boeing Company
Thesis	Dynamic Surface Tension and Adhesion Detection for the Rapid Analysis of Surfactants in Flowing Aqueous Liquids (1997)
Doctoral advisor	Robert E. Synovec

Nels Andrew Olson, American chemist, was born October 17, 1960 in Portland, Oregon. He is best known for his work in the development and synthesis of fluorogenic probes, high throughput analysis of biomolecules, the design of aerosol experiments for the study of disease transmission, and his work in the implementation of root cause analysis and corrective actions methods for complex systems.

Early career

Olson began his career as a shipbuilder and ship’s engineer, working primarily in the Alaskan Fishing Industry for Icicle Seafoods, Nuka Point Fisheries and others (1978-1993). While building vessels for the Alaskan fishing industry, Olson was employed at Margaret's Marine Ways, Bayside Machine Works, and Ross Troyer Boat Works. His apprenticeship was spent building the Nuka Island, one of Alaska’s premier crabbing and tendering vessels. At Ross Troyer Boat Works he was one of three welder/fitter/fabricators who built the Sea Mist and other whale back designs under owner operator Ross Troyer. His experience at sea and in other high risk environments prepared him for his later scientific work where the operational robustness of systems was also essential.

Education

A section of zebrafish retina probed with FRet 43, and developed for visualization with the ELF® 97 substrate.ELF® 97 enzyme-mediated substrate before and after enzymatic action. Olson obtained a B.A. in Biochemistry from Reed College in 1989 and worked as a synthetic carbohydrate chemist for Richard P. Haugland at Molecular Probes Inc. in Eugene, Oregon before returning to graduate school at University of Washington in Seattle (1993 to 1997). Olson's experiences working at Molecular Probes Inc. furthered his understanding of biological pathways, and structures, and the tools used to study them. His synthetic products included derivatives of the quinazolinones (ELF 97™) enzymatic substrates used to visualize the structures in the retina of the zebra fish and many other structural and process studies.

Olson's graduate education included extensive training in chemical separations, detector development, and complex signal processing with an emphasis on surface analysis of biomolecules and polymers in a non-vacuum environment. In addition, he studied biosynthetic pathways with Dr. Heinz G. Floss and performed syntheses in support of classical "feeding" experiments with isotopically labeled precursors to biosynthesis. During his final two years of graduate school, Olson also worked at the Positron Emission Tomography facility (University of Washington Medical Center) building robotic synthesis platforms for C-11 metabolic pathway probes.

Olson was awarded his Ph.D. in Chemistry in 1997. His dissertation advisor was Robert E. Synovec, an award winning analytical chemist renowned for his work in separation science and chemometrics. After completing his degree, Olson went immediately to Stockholm, Sweden where he was a Project Area Manager in the Food and Pharmaceutical Section of the Institute for Surface Chemistry located at the Royal Institute of Technology. He taught courses in data acquisition and analysis, surface analysis, and advised graduate students conducting experiments in support of the Section’s charter. During his second year in Stockholm, Olson was a Fulbright Fellow and worked on surface chemistry as it relates to high throughput protein recovery in the food processing industry. His projects also included cleaning analysis in the pharmaceutical processing environment, and molecular mobility in dense matrices such as sieving gels.

Commercial biotech

MegaBACE DNA sequencing instrument developed by Molecular Dynamics Advanced Research Team with Dr. David L. Barker. Here the instrument was fitted with a UV tunable laser for endogenous detection of proteins and peptides during separation by capillary electrophoresis Upon his return to the United States, Olson was employed by Molecular Dynamics as a Staff Scientist in the Advanced Research Team (ARTeam) in Dr. David L. Barker’s group where he studied and developed biocompatible surfaces for the manufacture of high throughput analysis instruments (MegaBACE™ and others). He and his team also built the first 96 capillary, variable wavelength, laser induced endogenous fluorescence, electrophoresis instrument, and demonstrated its peak capacity and sensitivity for multidimensional protein and peptide separations.

After the purchase of Molecular Dynamics by Amersham Pharmacia Biotech in 1999, Olson followed the executive team to the start up company, Illumina Inc., where he was an Associate Director and Senior Staff Scientist. There, Olson led teams of scientists and engineers in industrial failure analysis (forensics), building forensic analysis systems, implementing the FDA’s Quality System Regulations, part 820 of the Code of Federal Regulations title 21, and finally, building integrated robotic systems for synthesis, analysis and packaging of biotechnology products.

In 2007, Olson also filled in as the Director of Bio-Analysis at Insilicos Inc., and served on their Science Advisory Board from 2001 to 2012. In 2007, the company received a $1 million grant from the National Human Genome Research Institute to carry forward work on the Trans-Proteomic Pipeline (TPP), an open-sourced software suite for the analysis and visualization of mass spectrometry (MS) data. And in 2010 the company secured a $1.2 million grant from the National Institutes of Health for the analysis of biomarkers in the study of heart disease.

 

U.S. federal government

From 2006-2007 Dr. Olson took a civically oriented post as the chief of the Preservation Research Division at the Library of Congress. During his first three months at the Library, Olson was granted a 2.2 million dollar startup package to rebuild the library’s research and analysis laboratories. In the following nine months, Olson selected six new researchers for the Division (in addition to the ten original Ph.D., Master’s and Bachelor’s level contributors). He also oversaw the purchase and installation of twelve new instruments; established new, or maintained existing, collaborative programs with Lawrence Berkeley Labs (Dr. Carl Haber, Earl Cornell), Florida State University (Andre Striegel), University of Washington (Robert E. Synovec), Getty Institute (Jim Druzik), National Institute for Standards and Technology (NIST, Andre Striegel), Kislak Fellows (Rutgers University), and others; and finally, managed reconstruction planning for several new core laboratories at the Library. Olson also started a Professor in Residence Program for highly accomplished materials scientists (Andre Striegel first awardee). He was an advocate for filling open positions in his team with interns from the Hispanic Association of Colleges and Universities, and the Edmund Muskie Fellow Program in mathematics to analyze collection growth dynamics at the Library.

Library of Congress team responsible for creating the hermetically sealed encasement for the Waldseemüller Map While at LOC Olson’s work included serving on the Inter-agency Work Group on Digital Data, the Library of Congress Strategic Planning Team, and the Continuation of Operations Program for emergency scenarios. One of the large engineering projects that Olson supported was the building of the largest hermetically sealed encasement ever made for a document. In service of that project, Olson raised over $227,000 in donations from Alcoa Foundation, among others, and provided technical support, including the engineering of the monitoring and manifold systems for the encasement. This project, led by Elmer Eusman (third from left) and Olson (second from left) in collaboration with NIST, built the housing for the 1507 Waldseemüller map.. This map, the Universalis Cosmographiae}}, was based on data provided to Waldseemüller by Amerigo Vespucci, and was the origin of the modern name of the continents America.

From 2007-2010 Olson served as a senior level program manager for the Department of Homeland Security (DHS) working on instrument development and basic research into disease transmission and the detection of chemical and biological threats. His work also included the evaluation and selection of grants and contract recipients, and the management of investments to support the work of DHS. His portfolio of investments in research and development at this time was approximately $56M/year in contracts. Olson also chaired a number of investigations into root cause failure analysis and corrective action for biological threat technology, a subject he would pursue further during his later tenure at Boeing.

In 2009, Olson offered the keynote address at the 15th Detection Technologies conference. In that year, Olson also authored the Science & Technology Basic Research Focus Areas and portions of the High-Priority Technology Needs documents for DHS, And he was a contributing author on the DHS Chemical and Biological Countermeasures Division Strategic Plan.

In 2010, Olson joined the Applied Physics Laboratory at Johns Hopkins University (JHU/APL, 2010-2013) where he worked as a project manager in the aerosol analysis group and was also a Program Manager for chemical and biological threat analysis and countermeasures. At JHU/APL, Olson was one of three primary authors of the Defense Advanced Research Projects Agency (DARPA) "Prophecy". program proposal for the study of viral evolution (with Andrew Feldman JHU/APL, and Harvard University's David Weitz).

While still at Johns Hopkins, the Intergovernmental Personnel Act made Olson a Mobility Program appointee to work on projects for the Defense Threat Reduction Agency (DTRA) where he served as senior analyst and advisor to the Biological Detection and Diagnostics Division

Boeing

In 2012 Olson made the move back to the West coast starting a new career in aerospace at the Boeing company. At Boeing, Olson is a Program Manager for the chemical analysis group and runs a team of individual contributors working on root cause failure analysis and corrective action science and engineering. This team's work is almost entirely on system level failures rather than component issues, and is often at the forefront of investigations at the corporate level. Instantaneous Biological Analyzer and Collector (IBAC) deployed in Boeing aircraft for the study of aerosol transmission of disease agents

During the pandemic Olson was enlisted in the Confident Travel Initiative (CTI) team where he was one of four senior program managers who designed Boeing’s system to analyze the likelihood of aerosol-based disease transmission. Olson's work on this initiative was a continuation of the threat identification work he had done at DHS. There he had identified technologies with promise, notably the work of David Silcott at "S3i"., and in August of 2020, Olson's Boeing team collaborated with S3i and others on the biological aerosol detection project undertaken under the aegis of the United States Transportation Command (USTRANSCOM). Olson was also the senior author on several of the peer-reviewed papers written on this subject during the pandemic.

While at Boeing, Olson has been one of the principal architects of a number of initiatives. These have included the development and implementation of environmental testing; continuous variable measures for the analysis of corrosion; the capability to test, in real-time, fire suppressants in a full-scale aircraft cargo mockup; and finally, the real time analysis of engine emissions while utilizing synthetic biofuels. The emissions projects have been focused on the challenges for operational mitigation of contrails sponsored by Dr. Steven Baughcum and the Boeing Company

Personal life

As a child, Olson lived in an unincorporated area near Portland called Garden Home. His father, Oscar Henry Olson, was an early employee and electrical engineer for Tektronix, and his mother, Mary Josephine Olson, was trained as a nurse and dedicated her life to the work of charity.

Nels Olson is married to Nataliya Olson, M.Sc. in Civil Engineering and a CPA who is also trained as a fraud investigator.

Selected publications

• Trent, Stephen; Davis, Angela; Wu, Tateh; Menard, Danny; Cummins, Joshua J.; Santarpia, Joshua L.; Olson, Nels A. (July 2022). "Inhaled Mass and Particle Removal Dynamics in Commercial Buildings and Aircraft Cabins (cover story)". ASHRAE. 64 (7).
• Zee, Malia; Davis, Angela C.; Clark, Andrew D.; Wu, Tateh; Jones, Stephan P.; Waite, Lindsay L.; Cummins, Joshua J.; Olson, Nels Andrew (December 2021). "Computational fluid dynamics modeling of cough transport in an aircraft cabin". Scientific Reports. 11. doi:10.1038/s41598-021-02663-8. article #23329.
• Pang, Jenna K.; Jones, Stephen P.; Waite, Lindsay L.; Olson, Nels A.; Atmur, Robert J.; Cummins, Joshua J. (September–October 2021). "Probability and Estimated Risk of SARS-CoV-2 Transmission in the Air Travel System: A Systemic Review and Meta-Analysis". Travel Medicine and Infectious Disease. 43. doi:10.1016/j.tmaid.2021.102133.
• Khanipov, Kamil; Golovko, Georgiy; Rojas, Mark; Albayrak, Levent; Dobretsberger, Otto; Pimenova, Maria; Olson, Nels; Chumakov, Sergei; Fofanov, Yuriy (November 2015). "CoCo: An application to store High-Throughput Sequencing data in compact text and binary file formats". 2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). Washington, DC, USA: IEEE. pp. 1117–1122. doi:10.1109/BIBM.2015.7359838. INSPEC Accession Number: 15668233.
• Chapter Author, Department of Homeland Security, Chemical and Biological Countermeasures Division Strategic Plan, 2010, Washington, DC.
• Contributing Author, for Chemical and Biological Countermeasures Division, Basic Research Focus Areas Version 1.0 Published by the Department of Homeland Security, Science and Technology Directorate, May 2009
• Youket, Michele; Olson, Nels (2007). "Compact Disc Service Life Studies by the Library of Congress". Archiving Proceedings. Society for Imaging Science and Technology: 99–104.
• Olson, Nels A.; Khandurina, Julia; Guttman, Andras (2004). "DNA profiling by capillary array electrophoresis with non-covalent fluorescent labeling". Journal of Chromatography A. 1051: 155–160. doi:10.1016/j.chroma.2004.08.067.
• Khandurina, Julia; Olson, Nels A.; Anderson, Abraham A.; Gray, Kevin A.; Guttman, Andras (October 2004). "Large-scale carbohydrate analysis by capillary array electrophoresis: Part 1. Separation and scale-up". Electrophoresis. 25 (18–19): 3117–3121. doi:10.1002/elps.200406047.
• Khandurina, Julia; Olson, Nels A.; Anderson, Abraham A.; Gray, Kevin A.; Guttman, Andras (October 2004). "Large-scale carbohydrate analysis by capillary array electrophoresis: Part 2. Data normalization and quantification". Electrophoresis. 25 (18–19): 3122–3127. doi:10.1002/elps.200406047.
• Olson, Nels A.; Synovec, Robert E.; Skogerboe, Kristen J. (1998). "Protein Separation and Surface Tension Detection". Journal of Chromatography A. 806: 239–250. doi:10.1016/S0021-9673(98)00017-X.