Mickael Tanter

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Mickael Tanter
Born (1970-12-31) December 31, 1970 (age 55)
Paimpol, Brittany, France
NationalityFrench
Alma materSupélec; University of Paris VII; ESPCI Paris
Known forUltrafast Ultrasound; Functional ultrasound imaging; Shear Wave elastography; Ultrasound Localization Microscopy;
AwardsMember of the French Academy of Sciences (since 2024); Member of the European Academy of Science (since 2019)
Scientific career
FieldsPhysics, Medical Imaging, Ultrasound Therapy
InstitutionsESPCI PSL University; INSERM
Doctoral advisorMathias Fink

Mickael Tanter (born 31 December 1970 in Paimpol, Brittany, France) is a french physicist and a member of the french Academy of Science. He is a Distinguished Professor of ESPCI PSL University and a Research Director at the French National Institute of Health and Medical Research (INSERM). He is known for pioneering contributions in the field of Ultrasound physics, biomedical technologies and neuroscience.

Biography

Mickael Tanter graduated from Centrale-Supélec (class of 1994) and obtained a Master's in Physics from the University of Paris VII in 1995. His PhD research focused on applying the concept of time-reversal of ultrasound waves to the treatment of brain tumors. After five years as a research scientist at CNRS, he became a Research Director at INSERM in 2005.

In 2007, he founded the INSERM unit "Physics of Waves for Medicine" (Inserm / ESPCI Paris / CNRS) at the Institut Langevin, where he developed numerous biomedical technologies in the fields of cancer diagnostics, cardiovascular diseases, neuroscience, and extracorporeal ultrasound therapy. From 2014 to 2018, he served as Deputy Director of the Institut Langevin, and in 2019, he founded the Physics for Medicine Institute of Paris, becoming its first director.

Mickael Tanter was a member of the Scientific Council of the Île-de-France Region from 2013 to 2017. He was the recipient of an Equipex project grant in 2013, a European Research Council (ERC) Advanced Grant in 2014, and a European Research Council Synergy Grant in 2023.

He has received numerous national and international distinctions, including the Grand Prize of the Fondation pour la Recherche Médicale in 2019, the Grand Prize of the European Society for Molecular Imaging in 2018, and the Grand Prize for Medicine and Medical Research of the City of Paris. In 2017, he received the Carl Hellmuth Hertz Award from the IEEE Ultrasonics Society "for his introduction of multiple revolutionary new ultrasound imaging technologies that have had an impact not only on academic research but also on industry."

In 2019, he was elected a member of the European Academy of Science, and in 2024, he was elected a member of the French Academy of Sciences.

Scientific contributions

Non-invasive brain therapy by ultrasound

During his doctoral studies, Mickael Tanter, together with his supervisor Mathias Fink, developed a wave-focusing technique based on the principle of time reversal, enabling adaptive focusing of ultrasound waves through the skull.[1]. This breakthrough made it possible to perform extracorporeal ultrasound therapy for brain pathologies using focused ultrasound. Between 1995 and 2015, with Mathias Fink and Jean-François Aubry, Mickael Tanter further developed this concept of transcranial ultrasound focusing[2], which is now used clinically for non-invasive brain surgery with focused ultrasound.

Ultrafast ultrasound imaging

Between 1998 and 2015, together with Mathias Fink, Mickael Tanter developed an imaging method that increased the frame rate of ultrasound scanners by a factor of 100, from 50 to 10,000 images per second. This revolution of ultrafast ultrasound[3] made it possible to capture physical phenomena within the human body occurring over extremely short timescales, notably allowing the tracking of mechanical vibrations in living tissue. This invention led, in 2005, to the creation by Mathias Fink, Mickael Tanter, and their doctoral student Jérémy Bercoff of the company Supersonic Imagine, the first to commercialize a clinical ultrafast ultrasound scanner. To date, more than 3000 devices have been installed in hospitals across over 80 countries.

Shear-wave elastography

In 2002, together with Jérémy Bercoff and Mathias Fink, Mickael Tanter combined ultrafast ultrasound imaging (10,000 images per second) with the generation of shear waves induced by the radiation force of ultrasonic focused beams. By imaging the propagation of these micro-vibrations within organs, they succeeded in quantitatively mapping the local stiffness of human tissues, thereby replacing the physician's intuitive palpation with a precise imaging method at millimeter scale[4]. In 2008, Mickael Tanter and Mathias Fink, together with their team, published the first clinical results of this shear-wave imaging technique combined with ultrafast ultrasound for breast cancer diagnosis[5]. Between 2008 and 2018, the two researchers, along with their colleagues and students, published numerous clinical studies demonstrating the value of this quantitative stiffness measurement for applications ranging from the diagnosis of breast and thyroid cancers to liver fibrosis, as well as cardiac and vascular diseases.

Functional ultrasound neuroimaging

Between 2011 and 2021, Mickael Tanter and his team invented and developed a new technique for functional brain imaging based on the use of ultrasound waves[6]. This method, called functional ultrasound imaging of the brain (fUS Imaging), makes it possible to image neuronal activity across the entire brain by detecting subtle variations in blood flow within cerebral vessels with very high spatial and temporal resolution[7]. First demonstrated in rodents, this technique was later extended by Tanter's team to clinical imaging[8], both during the first weeks after birthin human neonates[9] and during neurosurgical procedures. In 2015, Mickael Tanter, together with his colleagues Ludovic Lecointre, Bruno Osmanski, Mathieu Pernot, Thomas Deffieux, and Zsolt Lenkei, founded the company Iconeus, which commercializes the first ultrasound neuroimaging scanner.

Ultrasound Localization microscopy or super-resolution ultrasound

In 2010, Mickael Tanter and his team (Claudia Errico and Olivier Couture) invented an imaging method that enabled for the first time the non-invasive visualization of an entire organ vasculature at microscopic scale. This technique, called Ultrasound Localization Microscopy (ULM), makes it possible to observe an organ's vascularization from its largest arteries down to its smallest components — capillaries just a few micrometers in diameter. A major milestone was reached in 2015 with the demonstration of transcranial imaging of cerebral vasculature in rodents[10]. After several years of work, in 2021 Mickael Tanter, together with his former students Charlie Déméné and Justine Robin and their radiologist colleague Fabienne Perren, demonstrated the feasibility of transcranial angiography at microscopic resolution in humans[11].

Non invasive therapy of cardiac valvs using shock waves

Between 2008 and 2020, Mickael Tanter, together with his colleagues Mathieu Pernot and Mathias Fink, and cardiologist Emmanuel Messas — developed a therapeutic method for treating heart valves using ultrasound shock waves. This work led to the creation of the French company CardiaWave in 2015. In collaboration with CardiaWave, the researchers developed the first device capable of remotely fragmenting microcalcifications within the heart valve, thereby restoring its flexibility without any surgical intervention. The first clinical trials were successfully conducted in 2020[12]

Industrial and translational technology transfer

Throughout his career, Mickael Tanter has sought to create a virtuous cycle between academic research, clinical research, and industrial transfer. He continuously aims to ensure that inventions developed in his laboratory can be transferred to industry and made accessible to patients as quickly as possible. Since 1998, the research he has been involved in has led to the creation of six French companies: Echosens, Supersonic Imagine, CardiaWave, Iconeus, eMyoSound, and SonoMind.

Awards & honours

  • Prize Inserm Transfert of Disruptive Innovation with Ludovic Lecointre for the creation of Iconeus
  • Elected member of the french Academy of Science in December 2024
  • Prize of the Innovators - Lepoint 2024 Innovateurs 2024 - Le Point[13] (with Emmanuel Messas and Mathieu Pernot)
  • William Feindel Award of the Biomedical Imaging Network RBIQ, Montreal 2024[14]
  • Laureate of the ERC Synergy Grant NeuroSonogene in 2023 (with Serge Picaud and Anna Moroni)
  • Research Prize of the foundation Langlois in 2024 (with Mathieu Pernot and Clement Papadacci)
  • 2023 KU Leuven Ambassador's Chair Kulak,[15] Leuven Belgium
  • Ambassador France 2030 for Research and University since 2023
  • 2022 Gordon Moore Professor of Caltech University, Pasadena USA
  • Boerhaave Chair, Leiden University Medical Center, Netherlands 2021-2022[16]
  • Nominated for the European Inventor Prize with Mathias Fink in 2021
  • Elected Member of the European Academy of Science since 2019
  • Jozef Rotblat Prize of Physics for Medicine and Biology journal in 2019 for the most cited publication in Physics for Medicine of the last 5 years
  • Fellow of the European Alliance for Medical and Biological Engineering & Science[17] since 2019
  • Grand prize of the European Society of Molecular Imaging (ESMI)[18] in 2018
  • Britton Chance Distinguished Lecture of the World Molecular Imaging Society[19] in 2017
  • Carl Hellmuth Hertz Award de la société internationale IEEE Ultrasonics[20] en 2017
  • Grand Prize of the Fondation pour la Recherche Médicale in 2016
  • Outstanding Paper Award of the IEEE Transactions in Ultrasonics IEEE Transactions in Ultrasonics[21] en 2015
  • Grand Prize of the Foundation NRJ, Institut de France, Académie de Sciences in 2015
  • Roberts Prize of the journal Physics in Medicine and Biology in 2015 for the best paper of the year
  • Distinguished Lecture en Biomedical Engineering de la CalTech university, 2015
  • Carson-Zagzebski Distinguished Lecture of the American Association of Physics in Medicine, 2015
  • Research Prize of the foundation Langlois with his team in 2015
  • Prize of the foundation pour Therapeutic Innovation Béatrice Denys with Emmanuel Messas and Mathieu Pernot in 2015
  • Prize OPECST-INSERM Inserm in 2014
  • Laureate of European Research Council ERC Advanced Grant in 2013
  • Grand Prize of Medicine and Medical Research Jean Hamburger of Paris City in 2012
  • Honored Lecture of the Radiology Society of North America[22] in 2012
  • Prize Yves Rocard of the société française de Physique (S.F.P.) with his colleagues Mathias Fink, Jeremy Bercoff et Jacques Souquet in 2011
  • Sylvia Sorkin Greenfield Award of the American Association of Physicists in Medicine in 2011
  • Prize Montgolfier of the Société d'Encouragement de l'Industrie Nationale[23] in 2010
  • Prize Leon Brillouin of the Society of Electrical Engineering (SEE) and the IEEE in 2010.
  • Outstanding Paper Award of the international journal IEEE Transactions in Ultrasonics in 2010
  • Prize Frederic Lizzi of the International Society of Therapeutic Ultrasound[24] in 2009

References

  1. ↑ Tanter, Mickaël; Thomas, Jean-Louis; Fink, Mathias (1998-05-01). "Focusing and steering through absorbing and aberrating layers: Application to ultrasonic propagation through the skull". The Journal of the Acoustical Society of America. 103 (5): 2403–2410. doi:10.1121/1.422759. ISSN 0001-4966.
  2. ↑ Aubry, J.-F.; Tanter, M.; Pernot, M.; Thomas, J.-L.; Fink, M. (2003-01-01). "Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans". The Journal of the Acoustical Society of America. 113 (1): 84–93. doi:10.1121/1.1529663. ISSN 0001-4966.
  3. ↑ Tanter, Mickael; Fink, Mathias (January 2014). "Ultrafast imaging in biomedical ultrasound". IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 61 (1): 102–119. doi:10.1109/TUFFC.2014.6689779. ISSN 0885-3010.
  4. ↑ Bercoff, J.; Tanter, M.; Fink, M. (April 2004). "Supersonic shear imaging: a new technique for soft tissue elasticity mapping". IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control. 51 (4): 396–409. doi:10.1109/TUFFC.2004.1295425. ISSN 0885-3010.
  5. ↑ Tanter, Mickael; Bercoff, Jeremy; Athanasiou, Alexandra; Deffieux, Thomas; Gennisson, Jean-Luc; Montaldo, Gabriel; Muller, Marie; Tardivon, Anne; Fink, Mathias (September 2008). "Quantitative Assessment of Breast Lesion Viscoelasticity: Initial Clinical Results Using Supersonic Shear Imaging". Ultrasound in Medicine & Biology. 34 (9): 1373–1386. doi:10.1016/j.ultrasmedbio.2008.02.002.
  6. ↑ Macé, Emilie; Montaldo, Gabriel; Cohen, Ivan; Baulac, Michel; Fink, Mathias; Tanter, Mickael (August 2011). "Functional ultrasound imaging of the brain". Nature Methods. 8 (8): 662–664. doi:10.1038/nmeth.1641. ISSN 1548-7105.
  7. ↑ Deffieux, Thomas; Demene, Charlie; Pernot, Mathieu; Tanter, Mickael (June 2018). "Functional ultrasound neuroimaging: a review of the preclinical and clinical state of the art". Current Opinion in Neurobiology. 50: 128–135. doi:10.1016/j.conb.2018.02.001.
  8. ↑ Imbault, Marion; Chauvet, Dorian; Gennisson, Jean-Luc; Capelle, Laurent; Tanter, Mickael (2017-08-04). "Intraoperative Functional Ultrasound Imaging of Human Brain Activity". Scientific Reports. 7 (1): 7304. doi:10.1038/s41598-017-06474-8. ISSN 2045-2322. PMC 5544759. PMID 28779069.
  9. ↑ Baranger, Jerome; Demene, Charlie; Frerot, Alice; Faure, Flora; Delanoë, Catherine; Serroune, Hicham; Houdouin, Alexandre; Mairesse, Jerome; Biran, Valerie; Baud, Olivier; Tanter, Mickael (2021-02-17). "Bedside functional monitoring of the dynamic brain connectivity in human neonates". Nature Communications. 12 (1): 1080. doi:10.1038/s41467-021-21387-x. ISSN 2041-1723. PMC 7889933. PMID 33597538.
  10. ↑ Errico, Claudia; Pierre, Juliette; Pezet, Sophie; Desailly, Yann; Lenkei, Zsolt; Couture, Olivier; Tanter, Mickael (November 2015). "Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging". Nature. 527 (7579): 499–502. doi:10.1038/nature16066. ISSN 0028-0836.
  11. ↑ Demené, Charlie; Robin, Justine; Dizeux, Alexandre; Heiles, Baptiste; Pernot, Mathieu; Tanter, Mickael; Perren, Fabienne (2021-03-15). "Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients". Nature Biomedical Engineering. 5 (3): 219–228. doi:10.1038/s41551-021-00697-x. ISSN 2157-846X. PMC 7610356. PMID 33723412.
  12. ↑ Messas, Emmanuel; Ijsselmuiden, Alexander; Trifunović-Zamaklar, Danijela; Cholley, Bernard; Puymirat, Etienne; Halim, Jonathan; Karan, Radmila; van Gameren, Menno; Terzić, Duško; Milićević, Vladimir; Tanter, Mickael; Pernot, Mathieu; Goudot, Guillaume (December 2023). "Treatment of severe symptomatic aortic valve stenosis using non-invasive ultrasound therapy: a cohort study". The Lancet. 402 (10419): 2317–2325. doi:10.1016/S0140-6736(23)01518-0.
  13. ↑ "Découvrez le palmarès des inventeurs 2024". 29 February 2024.
  14. ↑ "Annual QBIN Scientific Day – RBIQ-QBIN" (in français). Retrieved 2024-05-01.
  15. ↑ "Ambassador's Chair Kulak - Prof. Dr. Mickaël Tanter".
  16. ↑ "Mickaël Tanter, Boerhaave Professorship Lecture of Leiden University 2021-2022" (in français).
  17. ↑ https://eambes.org/
  18. ↑ https://e-smi.eu/
  19. ↑ https://www.wmis.org/
  20. ↑ https://ieee-uffc.org/
  21. ↑ https://ieee-uffc.org/
  22. ↑ https://www.rsna.org/
  23. ↑ https://www.industrienationale.fr/
  24. ↑ https://istu.org/

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