MartaRosário
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Marta Rosário is a Portuguese neuro-biologist at the Charité - Universitätsmedizin Berlin, where she holds the professorship for developmental neurobiology.[1] Her research focuses on dendritic development. [2] She has held a number of competitive fellowships and research grants, including from the German Research Council (DFG).[3] Her research has been published in leading international journals,[4] including in Genes & Development,[5] Molecular Psychiatry,[6][7] Neuron,[8] Proceedings of the National Academy of Sciences,[9][10] and Sciences Advances.[11]
In a series of papers, Rosário identified and discussed the role of the Cdc42 GTPase-activating multiadaptor protein, NOMA-GAP, which forms the molecular basis for the regulation of dendritic branching during cortical development[5] and which regulates autism-like social behavior in the mouse.[6]
In an article in Science Advances in 2021,[11] Rosário analysed the build-up of the layered structure of the cerebral cortex, where nerve cells migrate to their destination according to a finely regulated pattern. With her colleagues, Rosário identified the underlying molecular and cellular mechanisms, especially the exact timing of two key processes controlled by the same regulatory protein. It ensures that nerve cells start their migration at the appropriate moment and then realign themselves in the layer they have reached, which is a novel take on a key moment of dendritic development.
References
- ↑ "Vita Marta Rosario".
- ↑ "Dendritic Development".
- ↑ "DFG - GEPRIS - Dr. Marta de Rocha Rosário".
- ↑ "Marta Rosário".
- ↑ 5.0 5.1 Rosário, Marta; Schuster, Steffen; Jüttner, René; Parthasarathy, Srinivas; Tarabykin, Victor; Birchmeier, Walter (2012-08-01). "Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin". Genes & Development. 26 (15): 1743–1757. doi:10.1101/gad.191593.112. ISSN 0890-9369. PMC 3418591. PMID 22810622.
- ↑ 6.0 6.1 Schuster, S.; Rivalan, M.; Strauss, U.; Stoenica, L.; Trimbuch, T.; Rademacher, N.; Parthasarathy, S.; Lajkó, D.; Rosenmund, C.; Shoichet, S. A.; Winter, Y.; Tarabykin, V.; Rosário, M. (September 2015). "NOMA-GAP/ARHGAP33 regulates synapse development and autistic-like behavior in the mouse". Molecular Psychiatry. 20 (9): 1120–1131. doi:10.1038/mp.2015.42. ISSN 1476-5578. PMID 25869807.
- ↑ Ambrozkiewicz, Mateusz C.; Borisova, Ekaterina; Schwark, Manuela; Ripamonti, Silvia; Schaub, Theres; Smorodchenko, Alina; Weber, A. Ioana; Rhee, Hong Jun; Altas, Bekir; Yilmaz, Rüstem; Mueller, Susanne; Piepkorn, Lars; Horan, Stephen T.; Straussberg, Rachel; Zaqout, Sami (June 2021). "The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc". Molecular Psychiatry. 26 (6): 1980–1995. doi:10.1038/s41380-020-0714-8. ISSN 1476-5578. PMID 32249816.
- ↑ Ambrozkiewicz, Mateusz C.; Schwark, Manuela; Kishimoto-Suga, Mika; Borisova, Ekaterina; Hori, Kei; Salazar-Lázaro, Andrea; Rusanova, Alexandra; Altas, Bekir; Piepkorn, Lars; Bessa, Paraskevi; Schaub, Theres; Zhang, Xin; Rabe, Tamara; Ripamonti, Silvia; Rosário, Marta (2018-12-05). "Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140". Neuron. 100 (5): 1097–1115.e15. doi:10.1016/j.neuron.2018.10.008. ISSN 0896-6273. PMID 30392800.
- ↑ Hellmuth, Klaus; Grosskopf, Stefanie; Lum, Ching Tung; Würtele, Martin; Röder, Nadine; von Kries, Jens Peter; Rosario, Marta; Rademann, Jörg; Birchmeier, Walter (2008-05-20). "Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking". Proceedings of the National Academy of Sciences. 105 (20): 7275–7280. doi:10.1073/pnas.0710468105. ISSN 0027-8424. PMC 2438240. PMID 18480264.
- ↑ Schaeper, Ute; Vogel, Regina; Chmielowiec, Jolanta; Huelsken, Joerg; Rosario, Marta; Birchmeier, Walter (2007-09-25). "Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo". Proceedings of the National Academy of Sciences. 104 (39): 15376–15381. doi:10.1073/pnas.0702555104. ISSN 0027-8424. PMC 2000540. PMID 17881575.
- ↑ 11.0 11.1 Epifanova, Ekaterina; Salina, Valentina; Lajkó, Denis; Textoris-Taube, Kathrin; Naumann, Thomas; Bormuth, Olga; Bormuth, Ingo; Horan, Stephen; Schaub, Theres; Borisova, Ekaterina; Ambrozkiewicz, Mateusz C.; Tarabykin, Victor; Rosário, Marta (2021-07-02). "Adhesion dynamics in the neocortex determine the start of migration and the post-migratory orientation of neurons". Science Advances. 7 (27). doi:10.1126/sciadv.abf1973. hdl:2268/303082. ISSN 2375-2548. PMID 34215578.
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