Krista Varady

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Krista Varady
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NationalityCanadian
CitizenshipCanada
Education
  • Dietetics
  • PhD
Alma mater
  • University of Guelph
  • McGill University
OccupationScientist

Krista A. Varady is a Canadian-American scientist known for her studies of intermittent fasting on metabolic health in human subjects. She is currently a professor of nutrition at the University of Illinois Chicago (UIC) in the department of Kinesiology and Nutrition. She also serves as the director of the Human Nutrition Research Center at UIC. Her work is funded by the National Institutes of Health and the American Heart Association.

Education

Varady was born in Guelph, Ontario, Canada. She completed her Bachelor’s degree in dietetics at the University of Guelph. She then attended McGill University, where she completed her PhD in human nutrition. Her PhD dissertation examined the effects of plant sterols combined with exercise on cholesterol metabolism.[1] After her PhD, she joined the laboratory of Dr. Mark Hellerstein at the University of California, Berkeley, to study the health benefits of intermittent fasting. While at Berkeley, she published several pioneering animal studies in this area,[2][3][4] and the first literature of intermittent fasting.[5]

Studies of alternate day fasting

Varady has published numerous seminal articles examining how alternate day fasting impacts human health. In 2017, her lab published the first long-term (12-month) human trial of fasting.[6] This study showed that alternate day fasting is just as effective as traditional dieting, i.e daily calorie restriction, for weight loss and weight maintenance.[7] Her lab has also published several key studies demonstrating that intermittent fasting is a safe diet therapy [8] that can be used to lower cholesterol levels, blood pressure, and improve glycemic control in individuals with obesity and pre-diabetes.[9][10][11][12][13]

Studies of time restricted eating

In 2018, she began studying the impact of time restricted eating. Her studies show that eating within 4-hour [14] or 8-hour[15] window each day is safe [16] and effective for lowering body weight, reducing blood pressure, insulin resistance, and oxidative stress in adults with obesity. She has also published notable review articles [17] [18][19] summarizing the emerging benefits of time restricted eating.

Honors

In 2017 she received the Mead Johnson Young Investigator Award from the American Society for Nutrition for her work in intermittent fasting.[citation needed]

References

  1. ↑ Varady, Krista A; Ebine, Naoyuki; Vanstone, Catherine A; Parsons, William E; Jones, Peter JH (2004-11-01). "Plant sterols and endurance training combine to favorably alter plasma lipid profiles in previously sedentary hypercholesterolemic adults after 8 wk". The American Journal of Clinical Nutrition. 80 (5): 1159–1166. doi:10.1093/ajcn/80.5.1159. ISSN 0002-9165.
  2. ↑ Varady, K.A.; Roohk, D.J.; Loe, Y.C.; McEvoy-Hein, B.K.; Hellerstein, M.K. (October 2007). "Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice". Journal of Lipid Research. 48 (10): 2212–2219. doi:10.1194/jlr.M700223-JLR200.
  3. ↑ Varady, K. A.; Roohk, D. J.; McEvoy‐Hein, B. K.; Gaylinn, B. D.; Thorner, M. O.; Hellerstein, M. K. (June 2008). "Modified alternate‐day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice". The FASEB Journal. 22 (6): 2090–2096. doi:10.1096/fj.07-098178. ISSN 0892-6638. PMC 2975447. PMID 18184721.
  4. ↑ Varady, Krista A.; Allister, Candice A.; Roohk, Donald J.; Hellerstein, Marc K. (March 2010). "Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction☆". The Journal of Nutritional Biochemistry. 21 (3): 188–195. doi:10.1016/j.jnutbio.2008.11.001.
  5. ↑ Varady, Krista A; Hellerstein, Marc K (2007-07-01). "Alternate-day fasting and chronic disease prevention: a review of human and animal trials". The American Journal of Clinical Nutrition. 86 (1): 7–13. doi:10.1093/ajcn/86.1.7. ISSN 0002-9165.
  6. ↑ Trepanowski, John F.; Kroeger, Cynthia M.; Barnosky, Adrienne; Klempel, Monica C.; Bhutani, Surabhi; Hoddy, Kristin K.; Gabel, Kelsey; Freels, Sally; Rigdon, Joseph; Rood, Jennifer; Ravussin, Eric (2017-07-01). "Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial". JAMA Internal Medicine. 177 (7): 930. doi:10.1001/jamainternmed.2017.0936. ISSN 2168-6106.
  7. ↑ Trepanowski, John F.; Kroeger, Cynthia M.; Barnosky, Adrienne; Klempel, Monica C.; Bhutani, Surabhi; Hoddy, Kristin K.; Gabel, Kelsey; Freels, Sally; Rigdon, Joseph; Rood, Jennifer; Ravussin, Eric (2017-07-01). "Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial". JAMA Internal Medicine. 177 (7): 930. doi:10.1001/jamainternmed.2017.0936. ISSN 2168-6106.
  8. ↑ Hoddy, Kristin K; Kroeger, Cynthia M; Trepanowski, John F; Barnosky, Adrienne R; Bhutani, Surabhi; Varady, Krista A (December 2015). "Safety of alternate day fasting and effect on disordered eating behaviors". Nutrition Journal. 14 (1): 44. doi:10.1186/s12937-015-0029-9. ISSN 1475-2891.
  9. ↑ Varady, Krista A; Bhutani, Surabhi; Church, Emily C; Klempel, Monica C (2009-11-01). "Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults". The American Journal of Clinical Nutrition. 90 (5): 1138–1143. doi:10.3945/ajcn.2009.28380. ISSN 0002-9165.
  10. ↑ Varady, Krista A; Bhutani, Surabhi; Klempel, Monica C; Kroeger, Cynthia M; Trepanowski, John F; Haus, Jacob M; Hoddy, Kristin K; Calvo, Yolian (December 2013). "Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial". Nutrition Journal. 12 (1): 146. doi:10.1186/1475-2891-12-146. ISSN 1475-2891.
  11. ↑ Bhutani, Surabhi; Klempel, Monica C.; Kroeger, Cynthia M.; Trepanowski, John F.; Varady, Krista A. (July 2013). "Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans: Alternate Day Fasting and Exercise for Weight Loss". Obesity. 21 (7): 1370–1379. doi:10.1002/oby.20353.
  12. ↑ Gabel, Kelsey; Kroeger, Cynthia M.; Trepanowski, John F.; Hoddy, Kristin K.; Cienfuegos, Sofia; Kalam, Faiza; Varady, Krista A. (2019-07-22). "Differential Effects of Alternate‐Day Fasting Versus Daily Calorie Restriction on Insulin Resistance". Obesity: oby.22564. doi:10.1002/oby.22564. ISSN 1930-7381. PMC 7138754. PMID 31328895.
  13. ↑ Hoddy, Kristin K.; Kroeger, Cynthia M.; Trepanowski, John F.; Barnosky, Adrienne; Bhutani, Surabhi; Varady, Krista A. (December 2014). "Meal timing during alternate day fasting: Impact on body weight and cardiovascular disease risk in obese adults: Meal Timing During Alternate Day Fasting". Obesity. 22 (12): 2524–2531. doi:10.1002/oby.20909.
  14. ↑ Cienfuegos, Sofia; Gabel, Kelsey; Kalam, Faiza; Ezpeleta, Mark; Wiseman, Eric; Pavlou, Vasiliki; Lin, Shuhao; Oliveira, Manoela Lima; Varady, Krista A. (September 2020). "Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity". Cell Metabolism. 32 (3): 366–378.e3. doi:10.1016/j.cmet.2020.06.018.
  15. ↑ Gabel, Kelsey; Hoddy, Kristin K.; Haggerty, Nicole; Song, Jeehee; Kroeger, Cynthia M.; Trepanowski, John F.; Panda, Satchidananda; Varady, Krista A. (2018-06-15). "Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study". Nutrition and Healthy Aging. 4 (4): 345–353. doi:10.3233/NHA-170036.
  16. ↑ Gabel, Kelsey; Hoddy, Kristin K.; Varady, Krista A. (January 2019). "Safety of 8-h time restricted feeding in adults with obesity". Applied Physiology, Nutrition, and Metabolism. 44 (1): 107–109. doi:10.1139/apnm-2018-0389. ISSN 1715-5312.
  17. ↑ Patikorn, Chanthawat; Roubal, Kiera; Veettil, Sajesh K.; Chandran, Viji; Pham, Tuan; Lee, Yeong Yeh; Giovannucci, Edward L.; Varady, Krista A.; Chaiyakunapruk, Nathorn (2021-12-17). "Intermittent Fasting and Obesity-Related Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials". JAMA Network Open. 4 (12): e2139558. doi:10.1001/jamanetworkopen.2021.39558. ISSN 2574-3805. PMC 8683964. PMID 34919135.
  18. ↑ Varady, Krista A.; Cienfuegos, Sofia; Ezpeleta, Mark; Gabel, Kelsey (2022-02-22). "Clinical application of intermittent fasting for weight loss: progress and future directions". Nature Reviews Endocrinology. doi:10.1038/s41574-022-00638-x. ISSN 1759-5029.
  19. ↑ Varady, Krista A.; Cienfuegos, Sofia; Ezpeleta, Mark; Gabel, Kelsey (2021-10-11). "Cardiometabolic Benefits of Intermittent Fasting". Annual Review of Nutrition. 41 (1): 333–361. doi:10.1146/annurev-nutr-052020-041327. ISSN 0199-9885.

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