Katja Schenke-Layland

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Katja Schenke-Layland
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Born
Katja Schenke

(1977-03-21) 21 March 1977 (age 47)
Eisenach, Germany
NationalityGerman, American
CitizenshipGermany
Alma mater
  • University of Jen Children%27s Hospital Los Angeles
  • University of California, Los Angeles
Occupation
  • Professor
  • Institute Director
  • CEO
Websiteschenke-layland-lab.com

Katja Schenke-Layland (born Eisenach, Germany, March 21, 1977) is the Professor of Medical Technologies and Regenerative Medicine, Department for Women's Health at the University of Tübingen. [1] She is the Director of the Natural and Medical Sciences Institute at the University of Tübingen in Reutlingen (NMI).[2], Study Dean of Medical Technologies at the University of Tübingen, Director of the 3R Center for In Vitro Models and Alternatives to Animal Testing Tübingen, Director of the Department of Biomedical Sciences UKT and Project Scientist at the University of California, Los Angeles (UCLA), Dept. of Medicine/Cardiology, Los Angeles, CA, USA.

Early research

Katja Schenke-Layland began her doctoral work in the area of heart valve tissue engineering and non-invasive imaging at the University of Jena, Germany. Her specific interest was the effect of cryopreservation, decellularization/recellularization and biomechanical forces on heart valve extracellular matrix (ECM) structures and cells.[3][4][5] She helped develop the use of multiphoton laser-based confocal microscopy and second harmonic generation as non-invasive tissue imaging tools.[6] For her post-doctoral work, she focused on cardiac stem cell biology and biomaterials. Here, her seminal work was to be the first scientist to demonstrate that induced pluripotent stem cells (iPSCs) differentiate towards the cardiovascular and hematopoietic lineages, showing that beating cardiomyocytes could be derived from iPSCs.[7][8] She then returned to Germany to join the Fraunhofer IGB in Stuttgart, Germany as a group leader, which was then followed by her appointment as Professor at the UKT and promotion to Department Head and later Director of the Fraunhofer IGB. She remained focused on cardiovascular development[9][10] and biomaterials[11], and moved into the areas of in vitro test system[12][13] and Raman microspectroscopy[14][15], with a focus on ECM proteins.

Awards

  • Best Young Researcher Award/ Family Klee Prize, German Society for Biomedical Engineering
  • Young Investigator Morphological Sciences Award, American Association of Anatomists
  • Academia.net top female scientists in Germany[16]
  • Tissue Engineering and Regenerative Medicine International Society (TERMIS)-EU Young Investigator Award
  • CyberOne Business Plan Competition Finalist
  • RPB Harold F. Spalter International Scholar Award
  • Germany’s Top 100 Innovators[17]

Research focus

Currently, her research lab at the UKT focuses on the translation of human development into clinically relevant biomaterials and regenerative therapies, and the development of diagnostic tools to assess (stem) cell states, discover therapeutic candidates and diagnose diseases[18]. She leverages her appointments to bridge the gaps between science and industry to drive viable health care solutions, particularly at the NMI where they focus on supporting local SMEs[19]

Editorial work

Katja Schenke-Layland is currently the Co-Editor-In-Chief of Tissue Engineering Part B (Mary Ann Liebert) and Executive Editor of Advanced Drug Delivery Reviews[20] (Elsevier), as well as on the editorial boards of Matrix Biology (journal)[21] (Elsevier), Current Opinion in Biomedical Engineering (Elsevier), Journal of 3D Printing in Medicine (Future Medicine) and Scientific Reports (Nature Research). She is a fellow/ board member of the German National Academy of Science and Engineering[22], German Central Ethics Committee for Stem Cell Research[23], International and German Societies of Matrix Biology and the European Alliance for Medical and Biological Engineering and Science.

References

  1. ↑ "FIT - Portfolio". fit.uni-tuebingen.de.
  2. ↑ "Prof. Dr. Katja Schenke-Layland - NMI.de". www.nmi.de.
  3. ↑ Schenke-Layland, Katja; Madershahian, Navid; Riemann, Iris; Starcher, Barry; Halbhuber, Karl-Jürgen; König, Karsten; Stock, Ulrich A. (March 18, 2006). "Impact of Cryopreservation on Extracellular Matrix Structures of Heart Valve Leaflets". The Annals of Thoracic Surgery. 81 (3): 918–926. doi:10.1016/j.athoracsur.2005.09.016. PMID 16488695.
  4. ↑ Schenke-Layland, K.; Vasilevski, O.; Opitz, F.; König, K.; Riemann, I.; Halbhuber, K. J.; Wahlers, Th.; Stock, U. A. (September 1, 2003). "Impact of decellularization of xenogeneic tissue on extracellular matrix integrity for tissue engineering of heart valves". Journal of Structural Biology. 143 (3): 201–208. doi:10.1016/j.jsb.2003.08.002. PMID 14572475 – via ScienceDirect.
  5. ↑ Schenke-Layland, K.; Opitz, F.; Gross, M.; Döring, C.; Halbhuber, K. J.; Schirrmeister, F.; Wahlers, Th; Stock, U. A. (December 1, 2003). "Complete dynamic repopulation of decellularized heart valves by application of defined physical signals—an in vitro study". Cardiovascular Research. 60 (3): 497–509. doi:10.1016/j.cardiores.2003.09.002. PMID 14659795 – via academic.oup.com.
  6. ↑ König, K.; Schenke-Layland, K.; Riemann, I.; Stock, U. A. (February 1, 2005). "Multiphoton autofluorescence imaging of intratissue elastic fibers". Biomaterials. 26 (5): 495–500. doi:10.1016/j.biomaterials.2004.02.059. PMID 15276357 – via ScienceDirect.
  7. ↑ Schenke‐Layland, Katja; Rhodes, Katrin E.; Angelis, Ekaterini; Butylkova, Yekaterina; Heydarkhan‐Hagvall, Sepideh; Gekas, Christos; Zhang, Rui; Goldhaber, Joshua I.; Mikkola, Hanna K.; Plath, Kathrin; MacLellan, W. Robb (February 18, 2008). "Reprogrammed Mouse Fibroblasts Differentiate into Cells of the Cardiovascular and Hematopoietic Lineages". Stem Cells. 26 (6): 1537–1546. doi:10.1634/stemcells.2008-0033. PMC 2873147. PMID 18450826 – via Wiley Online Library.
  8. ↑ Schenke-Layland, Katja; MacLellan, W. Robb (October 13, 2009). "Induced Pluripotent Stem Cells". Circulation. 120 (15): 1462–1464. doi:10.1161/CIRCULATIONAHA.109.898544. PMC 2898560. PMID 19786628 – via ahajournals.org (Atypon).
  9. ↑ Votteler, Miriam; Berrio, Daniel A. Carvajal; Horke, Alexander; Sabatier, Laetitia; Reinhardt, Dieter P.; Nsair, Ali; Aikawa, Elena; Schenke-Layland, Katja (June 1, 2013). "Elastogenesis at the onset of human cardiac valve development". Development. 140 (11): 2345–2353. doi:10.1242/dev.093500. PMC 3912871. PMID 23637335 – via dev.biologists.org.
  10. ↑ Monaghan, Michael G.; Linneweh, Miriam; Liebscher, Simone; Handel, Ben Van; Layland, Shannon L.; Schenke-Layland, Katja (February 1, 2016). "Endocardial-to-mesenchymal transformation and mesenchymal cell colonization at the onset of human cardiac valve development". Development. 143 (3): 473–482. doi:10.1242/dev.133843. PMC 4760315. PMID 26674310 – via dev.biologists.org.
  11. ↑ Hinderer, Svenja; Seifert, Jan; Votteler, Miriam; Shen, Nian; Rheinlaender, Johannes; Schäffer, Tilman E.; Schenke-Layland, Katja (February 1, 2014). "Engineering of a bio-functionalized hybrid off-the-shelf heart valve". Biomaterials. 35 (7): 2130–2139. doi:10.1016/j.biomaterials.2013.10.080. PMID 24333025 – via www.sciencedirect.com.
  12. ↑ Brauchle, Eva; Johannsen, Hannah; Nolan, Samantha; Thude, Sibylle; Schenke-Layland, Katja (October 1, 2013). "Design and analysis of a squamous cell carcinoma in vitro model system". Biomaterials. 34 (30): 7401–7407. doi:10.1016/j.biomaterials.2013.06.016. PMID 23827189 – via www.sciencedirect.com.
  13. ↑ Zbinden, Aline; Marzi, Julia; Schlünder, Katharina; Probst, Christopher; Urbanczyk, Max; Black, Scott; Brauchle, Eva M.; Layland, Shannon L.; Kraushaar, Udo; Duffy, Garry; Schenke-Layland, Katja; Loskill, Peter (January 1, 2020). "Non-invasive marker-independent high content analysis of a microphysiological human pancreas-on-a-chip model". Matrix Biology. 85–86: 205–220. doi:10.1016/j.matbio.2019.06.008. PMID 31238092 – via www.sciencedirect.com.
  14. ↑ Brauchle, Eva; Kasper, Jana; Daum, Ruben; Schierbaum, Nicolas; Falch, Claudius; Kirschniak, Andreas; Schäffer, Tilman E.; Schenke-Layland, Katja (August 1, 2018). "Biomechanical and biomolecular characterization of extracellular matrix structures in human colon carcinomas". Matrix Biology. 68–69: 180–193. doi:10.1016/j.matbio.2018.03.016. PMID 29605717 – via www.sciencedirect.com.
  15. ↑ Marzi, Julia; Biermann, Anna C.; Brauchle, Eva M.; Brockbank, Kelvin G. M.; Stock, Ulrich A.; Schenke-Layland, Katja (February 5, 2019). "Marker-Independent In Situ Quantitative Assessment of Residual Cryoprotectants in Cardiac Tissues". Analytical Chemistry. 91 (3): 2266–2272. doi:10.1021/acs.analchem.8b04861. PMID 30601652 – via ACS Publications.
  16. ↑ https://www.academia-net.org/profil/prof-dr-katja-schenke-layland/1134189
  17. ↑ "Best Innovators: Germany's Quiet Visionaries". www.handelsblatt.com.
  18. ↑ "Schenke-Layland Lab". www.schenke-layland-lab.com.
  19. ↑ "Home - NMI.de". www.nmi.de.
  20. ↑ "Katja Schenke-Layland". www.journals.elsevier.com.
  21. ↑ "Katja Schenke-Layland, MSc, PhD". www.journals.elsevier.com.
  22. ↑ "Katja Schenke-Layland NMI Naturwissenschaftliches und Medizinisches Institut".
  23. ↑ "RKI - Mitglieder". www.rki.de.

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