Jan Karlseder

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Jan Karlseder
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Born (1968-09-28) September 28, 1968 (age 53)
NationalityAustrian
CitizenshipAustria
Alma materUniversity of Vienna
Occupation
  • Molecular Biologist
  • Professor

Jan Karlseder (born September 28, 1968, in Innsbruck) is an Austrian molecular biologist, a professor in the Molecular and Cellular Biology Laboratory, the Director of the Paul F. Glenn Center for Biology of Aging Research[1] and the holder of the Donald and Darlene Shiley Chair at the Salk Institute for Biological Studies.

Career

Karlseder obtained both his M.Sc. and his Ph.D. at the University of Vienna. In 1996, he joined the Laboratory of Titia de Lange at Rockefeller University in New York City for postdoctoral training. He became a faculty member at the Salk Institute for Biological Studies in 2002.

Research

Karlseder discovered that telomere dysfunction plays a role in Werner syndrome, a Progeroid syndromes aging disease that is associated with early onset of cancer. WRN helicase, which is mutated in Werner Syndrome patients, is required for efficient replication of the telomeric G-strand[2]. Without WRN, DNA replication strand replication frequently stalls at telomeres, leading to loss of one of the sister telomeres during replication and cell division. This telomere loss in turn can lead to telomere end-to-end fusions, fusion-bridge-breakage cycles and genome instability, which is responsible for the heightened cancer incidence in individuals with Werner Syndrome[3].

In the media

  

References

  1. "Glenn Foundation for Medical Research Glenn Center for Research on Aging". glennfoundation.org. Retrieved 2021-01-20.
  2. Crabbe, Laure; Verdun, Ramiro E.; Haggblom, Candy I.; Karlseder, Jan (2004-12-10). "Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity". Science. 306 (5703): 1951–1953. doi:10.1126/science.1103619. ISSN 0036-8075. PMID 15591207.
  3. Crabbe, L.; Jauch, A.; Naeger, C. M.; Holtgreve-Grez, H.; Karlseder, J. (2007-02-06). "Telomere dysfunction as a cause of genomic instability in Werner syndrome". Proceedings of the National Academy of Sciences. 104 (7): 2205–2210. doi:10.1073/pnas.0609410104. ISSN 0027-8424. PMC 1794219. PMID 17284601.

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