Hilário de Gouvêa

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Hilário de Gouvêa
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Died1929(1929-00-00) (aged 85–86)

Hilário de Gouvêa (1843-1929) was a Brazilian ophthalmologist noted for being the first person to document a case of hereditary cancer. [1] The cause of the recessive familial retinoblastoma he described was later further investigated and resulted in the first reported example of a tumor suppressor gene, Retinoblastoma protein.


  1. Monteiro, Alvaro N.A.; Waizbort, Ricardo (2007-05-30). "The accidental cancer geneticist: Hilário de Gouvêa and hereditary retinoblastoma". Cancer Biology & Therapy. 6 (5): 811–813. doi:10.4161/cbt.6.5.4420. ISSN 1538-4047.

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