Gregg G. Gundersen

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Gregg G. Gundersen
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BornMay 5, 1955
Known forMicrotubule post-translational modifications, nuclear movement
Academic background
EducationBSc, University of Wisonsin
PhD, 1983, University of Washington
Thesis (1983)
Academic work
InstitutionsColumbia University

Gregg G. Gundersen is an American cell biologist and a faculty member in the Department of Pathology and Cell Biology at Columbia University.

Early life and education

Gundersen earned his PhD degree from the University of Washington in the lab of Bennett M Shapiro where he provided evidence that the sperm cell fusses its outer membrane with oocytes during fertilization.[1] He then went on to conduct a postdoctoral fellowship in the lab of his former wife, Jeannette Chloe Bulinski, at UCLA where he demonstrated that a subset of microtubules accumulate post-translational modifications.[2]. After a short postdoctoral fellowship at CalTech he and Bulinski moved to Columbia University where they took faculty positions in the departments of Anatomy and Cell Biology, and Pathology.

Career

Gundersen's work has focused on how the microtubule and actin cytokskeletons contribute to cell polarity in mammalian cells. His lab demonstrated that a subset of microtubules that are oriented towards the leading edge of migrating cells become stabilized by formins, and +TIP proteins, including EB1 and APC.[3][4] He also provided evidence that the LINC complex drives nuclear migration in polarized mammalian cells by connecting the nucleus to the actin cytoskeleton.[5][6] His lab has also made seminal advances in how the actin and microtubule cytoskeletons regulate cell attachments (also known as focal adhesions) to the extracellular matrix.[7][8]

References

  1. Gundersen GG, Shapiro BM (1984). "Sperm surface proteins persist after fertilization". J Cell Biol. 99 (4 Pt 1): 1343–53. doi:10.1083/jcb.99.4.1343. PMC 2113326. PMID 6434548.
  2. Gundersen GG, Kalnoski MH, Bulinski JC (1984). "Distinct populations of microtubules: tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo". Cell. 38 (3): 779–89. doi:10.1016/0092-8674(84)90273-3. PMID 6386177.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. Palazzo AF, Cook TA, Alberts AS, Gundersen GG (2001). "mDia mediates Rho-regulated formation and orientation of stable microtubules". Nat Cell Biol. 3 (8): 723–9. doi:10.1038/35087035. PMID 11483957.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. Wen Y, Eng CH, Schmoranzer J, Cabrera-Poch N, Morris EJ, Chen M; et al. (2004). "EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration". Nat Cell Biol. 6 (9): 820–30. doi:10.1038/ncb1160. PMID 15311282.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. Gomes ER, Jani S, Gundersen GG (2005). "Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells". Cell. 121 (3): 451–63. doi:10.1016/j.cell.2005.02.022. PMID 15882626.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. Luxton GW, Gomes ER, Folker ES, Vintinner E, Gundersen GG (2010). "Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement". Science. 329 (5994): 956–9. doi:10.1126/science.1189072. PMC 3938394. PMID 20724637.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. Smilenov LB, Mikhailov A, Pelham RJ, Marcantonio EE, Gundersen GG (1999). "Focal adhesion motility revealed in stationary fibroblasts". Science. 286 (5442): 1172–4. doi:10.1126/science.286.5442.1172. PMID 10550057.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. Ezratty EJ, Partridge MA, Gundersen GG (2005). "Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase". Nat Cell Biol. 7 (6): 581–90. doi:10.1038/ncb1262. PMID 15895076.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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