Gary Hardiman

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Gary Hardiman
Born1967
 Ireland
NationalityIrish
Alma materUniversity of Galway
Scientific career
FieldsMolecular Biology,
Systems Biology,
Omics Technologies,
Bioinformatics,
Big Data Integration,
Precision Medicine,
Cancer Research,
Environmental Health,
Environmental Toxicology,
Food Systems Biology,
Space Biology
InstitutionsQueen's University, Belfast,UK
Medical University of South Carolina (MUSC)
University of California, San Diego (UCSD)
DNAX Research Institute in Palo Alto, California
Doctoral advisorFrank Gannon

Gary (Gerard Thomas) Hardiman, FRSB[1] is a molecular biologist and bioinformatics expert specializing in systems biology, transcriptomics, and data-driven approaches to human health and disease. He holds the Chair in Food Systems Biology at the Institute for Global Food Security[2] (IGFS) at Queen's University Belfast (QUB) [1[3]],and has joint appointments with the Medical University of South Carolina (MUCS)[2[4]]. His research, shaped during his postdoctoral work at DNAX Institute and his role as the founding director of the Biomedical Genomics Facility at University of California, San Diego, focuses on the intersection of molecular and computational biology.

Hardiman's work in environmental pollutants, space travel, and the genetic basis of disease explores how these elements influence health, with a particular focus on developing precision medicine solutions through Altomics Datamation Ltd. The fields of Space Biology, Precision Medicine, Cancer Research, and Environmental Toxicology are interconnected through genomic, multi-omics and big data integrative approaches. These disciplines rely on a cross-disciplinary strategy to understand the impact of environmental influences on environmental and human health.

Education and early life

Hardiman was born and raised in Galway, Ireland. He completed a Bachelor of Science with Honours (BSc.) in Microbiology at the University of Galway[5] (1985–1989) and earned a Doctor of Philosophy (Ph.D.) in Molecular Biology at the University of Galway (1989–1993) under the supervision of Frank Gannon.

Career and research

DNAX Research Institute

After completing his Ph.D., Hardiman conducted postdoctoral research at the DNAX Research Institute[6] in Palo Alto, California, focusing on molecular and computational biology. During this time, he contributed to the identification of novel cytokines[7] and chemokines.[8]

University of California (UCSD)

He briefly worked at Axys Pharmaceuticals before joining the University of California, San Diego (UCSD) in 2000, where he became the founding director of the Biomedical Genomics Facility. [5[9]]

Medical University of South Carolina (MUSC)

In 2014, Hardiman joined the Medical University of South Carolina (MUSC) as a Full Professor in the Department of Medicine and served as Director of the Center for Genomics Medicine Bioinformatics. [6[10]]

Queen's University Belfast (QUB)

In 2018, he joined Queen's University Belfast, where he continues his research. Gary Hardiman's research focuses on understanding complex biological systems to address challenges in health and disease. He studies environmental impacts on health, such as the effects of pollutants on ecosystems and humans and explores genetic and biological factors influencing cancer and substance abuse. His work also examines the effects of space travel on human biology and develops computational tools to improve the integration of biological data for better healthcare solutions.

At Queen's University Belfast, Hardiman[1[11]] is actively involved in teaching undergraduate and postgraduate students, delivering courses on molecular biology, bioinformatics, and systems biology. He has mentored numerous Ph.D. students and postdoctoral researchers, fostering the next generation of scientists in fields ranging from genomics to environmental health.

AItomics Datamation

Beyond academia, Hardiman is a founder and Chief Technology Officer of Altomics Datamation Ltd,[12] a Northern Ireland-based precision medicine company specializing in proteomics and data-driven healthcare solutions.[7[13]]

Memberships

  • Royal Society of Biology (FRSB)[14]
  • Society of Environmental Toxicology and Chemistry (SETAC)
  • American Association for the Advancement of Science (AAAS)[15]

Awards and honours

Hardiman is a Fellow of the Royal Society of Biology and is a member of the editorial boards of multiple scientific journals. He serves as the Section Editor-in-Chief for Computational Biology at the journal Biotech. Hardiman frequently participates in international conferences related to systems biology, bioinformatics, and cancer research, including events such as the European Comparative Endocrinologists[16] (CECE) 2024 and the Food Integrity Global conference. His research has been published in over 200 peer-reviewed articles in journals including Nature, Cell, and PNAS. Additionally, he has edited books on topics such as genomics technology, systems biology, and environmental contaminants.

Publications and their focus areas

Books

The following books provide insights into various biological disciplines, emphasizing advancements in technology, data analysis, and applications across genomics, environmental health, and systems biology:

  • Environmental Contaminants and Endocrine Health (2023)[17] This book explores the effects of environmental contaminants on endocrine systems. It delves into biological pathways influenced by toxins and examines complex interactions between environmental factors and endocrine health.
  • System Analytics and Integration of Big Omics Data (2020)[18][19] This work highlights the role of computational tools and data integration in analyzing large-scale biological datasets. It emphasizes the combination of genomics, transcriptomics, and proteomics to derive system-level insights.
  • Microarray Innovations: Technology and Experimentation (2009)[20] This book discusses advances in microarray technology, with a focus on their application in analyzing gene expression and genetic variations.
  • Biochips as Pathways to Drug Discovery (2003)[21] This publication explores the role of biochips in drug discovery, focusing on their utility in studying protein interactions and molecular mechanisms.
  • Microarrays Methods and Applications: Nuts & Bolts (2003)[22] This book provides a practical overview of microarray technology, detailing methods for analyzing gene expression and RNA applications.

Publications and research insights

The list below includes publications showcasing research across different biological disciplines :

References

  1. ↑ https://www.rsb.org.uk/membership/individual-membership/fellowship-frsb
  2. ↑ https://www.qub.ac.uk/Research/GRI/TheInstituteforGlobalFoodSecurity/
  3. ↑ https://www.qub.ac.uk/schools/SchoolofBiologicalSciences/Connect/AcademicStaff/ProfessorGaryHardiman/
  4. ↑ https://garyhardiman.com/
  5. ↑ https://www.universityofgalway.ie/
  6. ↑ https://fr.linkedin.com/company/dnax-research-institute
  7. ↑ https://www.nature.com/articles/385640a0
  8. ↑ Rock, Fernando L.; Hardiman, Gary; Timans, Jackie C.; Kastelein, Robert A.; Bazan, J. Fernando (1998). "A family of human receptors structurally related to Drosophila Toll". Proceedings of the National Academy of Sciences. 95 (2): 588–593. Bibcode:1998PNAS...95..588R. doi:10.1073/pnas.95.2.588. PMID 9435236.
  9. ↑ https://www.yumpu.com/en/document/read/4018063/ucsds-gary-hardiman-discusses-the-future-of-core-biogem
  10. ↑ https://research.musc.edu/stories/news/2017/12/05/guardians-of-the-environment
  11. ↑ https://www.qub.ac.uk/schools/SchoolofBiologicalSciences/Connect/AcademicStaff/ProfessorGaryHardiman/
  12. ↑ https://altomicsdatamation.com/
  13. ↑ https://altomicsdatamation.com/
  14. ↑ https://www.rsb.org.uk/membership/individual-membership/fellowship-frsb
  15. ↑ https://www.aaas.org/
  16. ↑ https://escendoinfo.blogspot.com/
  17. ↑ CARNEVALI, Oliana (2023-05-30). Environmental Contaminants and Endocrine Health. Vol. 19. Cambridge, Massachussets, USA: Academic Press, Massachussets, USA. pp. 147–148. doi:10.4183/aeb.2023.147. ISBN 978-0-12824-464-7. PMC 10439325.
  18. ↑ HARDIMAN, Gary (2020-04-15). Systems Analytics and Integration of Big Omics Data. Basel, Switzerland: Mdpi AG. ISBN 978-3-03928-744-4. Retrieved 2025-01-18.
  19. ↑ CARNEVALI, Oliana; HARDIMAN, Gary (2023-05-30). Environmental Contaminants and Endocrine Health. Cambridge, Massachussets, USA: Academic Press. ISBN 978-0-12824-464-7.
  20. ↑ HARDIMAN, Gary (2009-04-01). Hardiman, Gary (ed.). Microarray Innovations Technology and Experimentation. Boca Raton, Florida, USA: CRC Press. doi:10.1201/9781420094510. ISBN 978-1-42009-448-0.
  21. ↑ HARDIMAN, Gary; CARMEN, Andrew (2003-01-01). Biochips as Pathways to Drug Discovery. Boca Raton, Florida, USA: CRC Press. doi:10.1201/9781420015607. ISBN 978-1-57444-450-6. Retrieved 2025-01-18.
  22. ↑ HARDIMAN, Gary (2003-01-01). Microarrays Methods and Applications : Nuts & Bolts. Seattle, Washington, USA: DNA Press. ISBN 978-0-96640-276-6. Retrieved 2025-01-01.
  23. ↑ Dennis, E. A.; Deems, R. A.; Harkewicz, R.; Quehenberger, O.; Brown, H. A.; Milne, S. B.; Myers, D. S.; Glass, C. K.; Hardiman, G.; Reichart, D.; Merrill Jr, A. H.; Sullards, M. C.; Wang, E.; Murphy, R. C.; Raetz, C. R.; Garrett, T. A.; Guan, Z.; Ryan, A. C.; Russell, D. W.; McDonald, J. G.; Thompson, B. M.; Shaw, W. A.; Sud, M.; Zhao, Y.; Gupta, S.; Maurya, M. R.; Fahy, E.; Subramaniam, S. (2010). "A mouse macrophage lipidome". The Journal of Biological Chemistry. 285 (51): 39976–39985. doi:10.1074/jbc.M110.182915. PMC 3000979. PMID 20923771.
  24. ↑ Bazan, J. F.; Bacon, K. B.; Hardiman, G.; Wang, W.; Soo, K.; Rossi, D.; Greaves, D. R.; Zlotnik, A.; Schall, T. J. (1997). "A new class of membrane-bound chemokine with a CX3C motif". Nature. 385 (6617): 640–644. doi:10.1038/385640a0. PMID 9024663.
  25. ↑ Hardiman, G.; Rock, F. L.; Balasubramanian, S.; Kastelein, R. A.; Bazan, J. F. (1996). "Molecular characterization and modular analysis of human MyD88". Oncogene. 13 (11): 2467–2475. PMID 8957090.
  26. ↑ Da Silveira, W. A.; Renaud, L.; Simpson, J.; Glen Jr, W. B.; Hazard, E. S.; Chung, D.; Hardiman, G. (2018). "MiRmapper: A Tool for Interpretation of miRNA⁻mRNA Interaction Networks". Genes. 9 (9): 458. doi:10.3390/genes9090458. PMC 6162471. PMID 30223528.
  27. ↑ Hardiman, G.; Savage, S. J.; Hazard, E. S.; Wilson, R. C.; Courtney, S. M.; Smith, M. T.; Hollis, B. W.; Halbert, C. H.; Gattoni-Celli, S. (2016). "Systems analysis of the prostate transcriptome in African-American men compared with European-American men". Pharmacogenomics. 17 (10): 1129–1143. doi:10.2217/pgs-2016-0025. PMC 6040053. PMID 27359067.
  28. ↑ Xu, E. G.; Mager, E. M.; Grosell, M.; Pasparakis, C.; Schlenker, L. S.; Stieglitz, J. D.; Benetti, D.; Hazard, E. S.; Courtney, S. M.; Diamante, G.; Freitas, J.; Hardiman, G.; Schlenk, D. (2016). "Time- and Oil-Dependent Transcriptomic and Physiological Responses to Deepwater Horizon Oil in Mahi-Mahi (Coryphaena hippurus) Embryos and Larvae". Environmental Science & Technology. 50 (14): 7842–7851. Bibcode:2016EnST...50.7842X. doi:10.1021/acs.est.6b02205. PMID 27348429.
  29. ↑ Taniguchi, K.; Wu, L. W.; Grivennikov, S. I.; De Jong, P. R.; Lian, I.; Yu, F. X.; Wang, K.; Ho, S. B.; Boland, B. S.; Chang, J. T.; Sandborn, W. J.; Hardiman, G.; Raz, E.; Maehara, Y.; Yoshimura, A.; Zucman-Rossi, J.; Guan, K. L.; Karin, M. (2015). "A gp130-SRC-YAP module links inflammation to epithelial regeneration". Nature. 519 (7541): 57–62. Bibcode:2015Natur.519...57T. doi:10.1038/nature14228. PMC 4447318. PMID 25731159.
  30. ↑ https://pureadmin.qub.ac.uk/ws/portalfiles/portal/234476289/
  31. ↑ Biamis, Christina; Driscoll, Kieran O'; Hardiman, Gary (2021). "Microplastic toxicity: A review of the role of marine sentinel species in assessing the environmental and public health impacts". Case Studies in Chemical and Environmental Engineering. 3. Bibcode:2021CSCEE...300073B. doi:10.1016/j.cscee.2020.100073.
  32. ↑ Da Silveira, W. A.; et al. (2020). "Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact". Cell. 183 (5): 1185–1201.e20. Bibcode:2020Cell..183.1185D. doi:10.1016/j.cell.2020.11.002. PMC 7870178. PMID 33242417.
  33. ↑ Cahill, T.; Hardiman, G. (2020). "Nutritional challenges and countermeasures for space travel". Nutrition Bulletin. 45 (1): 98–105. doi:10.1111/nbu.12422.
  34. ↑ Davis-Turak, J.; Courtney, S. M.; Hazard, E. S.; Glen Jr, W. B.; Da Silveira, W. A.; Wesselman, T.; Harbin, L. P.; Wolf, B. J.; Chung, D.; Hardiman, G. (2017). "Genomics pipelines and data integration: Challenges and opportunities in the research setting". Expert Review of Molecular Diagnostics. 17 (3): 225–237. doi:10.1080/14737159.2017.1282822. PMC 5580401. PMID 28092471.
  35. ↑ Hardiman, G.; Gannon, F. (1996). "Differential transferrin gene expression in Atlantic salmon (Salmo salar L.) freshwater parr and seawater smolts". Journal of Applied Ichthyology. 12 (1): 43–47. Bibcode:1996JApIc..12...43H. doi:10.1111/j.1439-0426.1996.tb00058.x.
  36. ↑ Baker, M. E.; Ruggeri, B.; Sprague, L. J.; Eckhardt-Ludka, C.; Lapira, J.; Wick, I.; Soverchia, L.; Ubaldi, M.; Polzonetti-Magni, A. M.; Vidal-Dorsch, D.; Bay, S.; Gully, J. R.; Reyes, J. A.; Kelley, K. M.; Schlenk, D.; Breen, E. C.; Šášik, R.; Hardiman, G. (2008). "Analysis of Endocrine Disruption in Southern California Coastal Fish Using an Aquatic Multispecies Microarray". Environmental Health Perspectives. 117 (2): 223–230. Bibcode:2009EnvHP.117..223B. doi:10.1289/ehp.11627. PMC 2649224. PMID 19270792.
  37. ↑ Talapatra, A.; Rouse, R.; Hardiman, G. (2002). "Protein microarrays: Challenges and promises". Pharmacogenomics. 3 (4): 527–536. doi:10.1517/14622416.3.4.527. PMID 12164775.
  38. ↑ Hardiman, G. (2004). "Microarray platforms--comparisons and contrasts". Pharmacogenomics. 5 (5): 487–502. doi:10.1517/14622416.5.5.487. PMID 15212585.

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