European Bank for induced pluripotent Stem Cells

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European Bank for induced pluripotent Stem Cells
NicknameEBiSC
TypeNon-profit
Region
Germany and the United Kingdom
Websiteebisc.org

The European Bank for induced pluripotent Stem Cells (EBiSC) is a non-profit induced pluripotent stem cell (iPSC) repository and service provider with central facilities in Germany and the United Kingdom.

EBiSC was set up between 2014 and 2017 by a consortium that represented researchers, clinicians and industry stakeholders[1]. A second phase of the project will run between 2019 and 2022 with the aim of consolidating EBiSC as a non-for-profit, self-sustainable iPSC bank and service provider.[2] The initiative is funded by the European Commission and the European Federation of Pharmaceutical Industries and Associations under the Innovative Medicines Initiative.[3][4]

The European Bank for induced pluripotent Stem Cells performs collection, banking, quality control and distribution of iPSC lines for research purposes. EBiSC’s stated goal is to supply academic, non-profit and commercial researchers with high-quality, disease-relevant iPSC lines, data and other services. It also seeks to promote the international standardisation of iPSC banking practices and to act as a central hub that ensures the sustainability and accessibility of iPSC lines generated by different research organisations. IPSC lines generated externally can be deposited into EBiSC for storage, banking, quality control and distribution.[5][6][7][8]

Catalogue and facilities

In February 2020, the EBiSC catalogue contained iPSC lines representing more than 30 different diseases and conditions such as Alzheimer’s disease,[9][10] Frontotemporal Dementia, Parkinson's disease, Huntington’s disease, Dravet syndrome, Bardet-Biedl syndrome, Mood disorder|depression and Pain|pain, diabetes mellitus, eye diseases and heart disease.[11] These iPSC lines have been deposited into EBiSC by academic institutions and non-profit and commercial organisations internationally. This includes lines generated within research projects such as StemBANCC, HipSci, IMI-ADAPTED, CRACK IT BadIPS and CRACK IT UnTangle.

The EBiSC Bank is run by two ISO9001:2015-compliant central facilities: the main distributor of EBiSC cell lines, the European Collection of Authenticated Cell Cultures in the UK, and the ‘mirror bank’ storing duplicates of all deposited lines long-term, established by the Fraunhofer Institute for Biomedical Engineering (IBMT) in Germany.

All EBiSC lines are distributed by the European Collection of Authenticated Cell Cultures operated by Public Health England.

References

  1. ↑ CORDIS: European Bank for induced pluripotent Stem Cells
  2. ↑ CORDIS: EBiSC2, A sustainable European Bank for induced pluripotent Stem Cells
  3. ↑ Innovative Medicines Initiative: EBiSC. https://www.imi.europa.eu/projects-results/project-factsheets/ebisc
  4. ↑ Innovative Medicines Initiative: EBiSC2. https://www.imi.europa.eu/projects-results/project-factsheets/ebisc2
  5. ↑ De Sousa, P et al. (March 2017). Rapid establishment of the European Stem Bank for induced Pluripotent Stem Cells (EBiSC) – the Hot Start experience. Stem Cell Research 20: 105-114.
  6. ↑ O'Shea O, Steeg R, Chapman C, Mackintosh P, Stacey GN. Development and implementation of large-scale quality control for the European bank for induced Pluripotent Stem Cells [published online ahead of print, 2020 Mar 20]. Stem Cell Res. 2020; 45:101773. doi:10.1016/j.scr.2020.101773
  7. ↑ Engle, Sandra J et al. (November 2018). Best Practices for Translational Disease Modeling Using Human iPSC-Derived Neurons. Neuron 100 (4): 783-797. URL: https://www.sciencedirect.com/science/article/pii/S0896627318309413. https://doi.org/10.1016/j.neuron.2018.10.033
  8. ↑ Scudellari, M (June 2016). How iPS cells changed the world. Induced pluripotent stem cells were supposed to herald a medical revolution. But ten years after their discovery, they are transforming biological research instead. Nature 534 (7607): 310-312. URL: https://www.nature.com/news/how-ips-cells-changed-the-world-1.20079
  9. ↑ Schmid, B et al (January 2019). Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line. Stem Cell Research 34. URL: https://www.sciencedirect.com/science/article/pii/S1873506118302794?via%3Dihub
  10. ↑ Public Health England (April 2017). EBiSC to develop next generation Alzheimer’s disease iPSC lines. URL: https://www.phe-culturecollections.org.uk/news/ecacc-news/ebisc-alzheimers.aspx
  11. ↑ Public Health England (October 2017). EBiSC: New panel of heart disease-specific iPSC lines for in vitro disease modelling and drug testing. URL: https://www.phe-culturecollections.org.uk/news/ecacc-news/ebisc-new-panel-of-heart-disease-specific-ipsc.aspx

External links

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