Dhevalapally B. Ramachary
Dhevalapally Buchi Ramachary
|Born||June 18, 1973|
Thatikal, Nalgonda, India.
|Alma mater||University of Hyderabad|
Indian Institute of Science
The Scripps Research Institute
|Institutions||University of Hyderabad|
|Thesis||Total synthesis of Sesquiterpenes containing three contiguous quaternary carbon atoms (2001)|
|Doctoral advisor||Prof. Adusumilli Srikrishna|
Dhevalapally Buchi Ramachary FTAS, FASc, FRSC, also known as D. B. Ramachary (born 18 June 1973), is an Indian Chemist and Professor at School of Chemistry, University of Hyderabad. He is notably known for his huge contribution towards organocatalytic sequential one-pot reactions, Ramachary reductive coupling (RRC), asymmetric supramolecular organocatalysis, push-pull dienamine-catalysis, aminoenyne-catalysis, BIRO reactions, and metal-free carbonyls based click chemistry.
Early life & education
D. B. Ramachary was born to Shri Ramalingaiahchary and Ramalingamma on 18 June 1973, at Thatikal village, Nakrekal mandal, Nalgonda district of Telangana. He did his early schooling at ZPHS schools at Thatikal and Nakrekal, and later joined for an under graduate BSc programme at Nagarjuna Government College (Autonomous) at Nalgonda (1991–1994). Later, he moved to School of Chemistry, University of Hyderabad for pursuing MSc chemistry (1994-96). His passion towards chemistry made him to secure PhD in synthetic organic chemistry under the guidance of Prof. A. Srikrishna at Indian Institute of Science in 1996–2001 for the total synthesis of sesquiterpenes like (±)-grimaldone, (±)-epigrimaldone, (±)-β-microbiotene, (±)-microbiotol and (±)-cyclocuparenol. Soon after PhD in 2001, he moved to US as a Skaggs Postdoctoral Fellow and worked with Prof. Carlos F. Barbas III at Department of Chemistry and Molecular Biology, The Scripps Research Institute in La Jolla, United States during 2002–2005 for the development of small molecular-catalysis.
Ramachary was Lecturer (2005–2007), Reader (2007–2010), Associate Professor (2010–2013), and at present he is a Full Professor of Organic Chemistry since 2013 at the Catalysis laboratory, School of Chemistry, University of Hyderabad. He has authored more than 100 research papers. He has delivered more than 100 invited lectures at the both national and international organizations.
Ramachary dealt with ‘Total synthesis of Sesquiterpenes containing three contiguous quaternary carbon atoms’ during his doctoral studies with Prof. Adusumilli Srikrishna’s Laboratory at Indian Institute of Science. In 2005, when Ramachary started his own research carrier at School of Chemistry, UoH, he showed interest towards discovering green reactions and catalysts. His laboratory mainly focused on the development of organocatalytic sequential one-pot reactions, asymmetric supramolecular catalysis and organocatalysis, development of multi-component and multi-catalysis cascade reaction, metal-free carbonyls based click chemistry. His research laboratory discovered important reactions based on three-component reductive alkylation (TCRA) and push-pull dienamine (PPD) reactions. His research also focuses on the theoretical aspects of organocatalysis in finding out the suitable organocatalyst for stereoselective reactions using computational resources which helps in achieving better synthetic methodologies. Using this, his research group observed the electrostatic and dipole-dipole interactions in proline-catalyzed asymmetric desymmetrization of pro-chiral ketones with nitrosobenzene. He has also undertaken the challenging research program by looking at the trapping or stabilizing of king size pre- or post-transition states of asymmetric reactions by designing new tool ‘asymmetric supramolecular catalysis’ through which characterization of large-size supramolecular rings in the pre-transition state (pre-TS) of enol- or enamine-based Michael reactions for high asymmetric induction was reported. He also developed many new green reactions and novels which received great attention from researchers in the scientific community across the world. His contributions through original developed reactions were used by organic, medicinal, material chemists. The reactions which are named after him are: 1) Ramachary Reductive Coupling Reaction, 2) Ramachary-Bressy-Wang Cycloaddition, 3) Ramachary Aminoenyne-catalysis, 4) Ramachary Base Induced Ring Opening (BIRO) Reaction, 5) Ramachary Azide-Carbonyl [3+2]-Cycloaddition.
Awards & Honors
- Fellow, Royal Society of Chemistry – 2020.
- Fellow, Indian Academy of Sciences, Bangalore – 2018.
- Fellow, Telangana Academy of Sciences – 2016.
- Top 10% of Highly Cited Author in RSC Organic and Medicinal Portfolio of Journals - Royal Society of Chemistry – 2016.
- International Advisory Board Member, European Journal of Organic Chemistry, January 2017 to present.
- Chemical Research Society of India (CRSI) Bronze Medal – 2016.
- The Chancellor Award – 2014.
- Member of Royal Society of Chemistry, 2014 to present.
- International Advisory Board Member, Organic & Biomolecular Chemistry, January 2013 to present.
- Certificate of Appreciation as Best Thesis Adviser from the Eli Lilly and Company, USA for the years 2014, 2013, 2012 and 2011.
- B. M. Birla Science Prize in Chemical Sciences – 2011.
- Anil Kumar Bose Memorial Award of the INSA – 2010.
- Associate Fellow of the Andhra Pradesh Academy of Sciences – 2010.
- Member of The National Academy of Sciences, Allahabad – 2009.
- Indian National Science Academy Medal for Young Scientist 2006.
- Member of Chemical Research Society of India (CRSI), Bangalore.
- Author profile published by European Journal of Organic Chemistry.
- Srikrishna, A.; Ramachary, D. B. (1999-09-03). "First total synthesis of (±)-β-microbiotene, (±)-microbiotol and (±)-cyclocuparenol". Tetrahedron Letters. 40 (36): 6669–6670. doi:10.1016/S0040-4039(99)01342-8. ISSN 0040-4039.
- Srikrishna, A.; Ramachary, D. B. (2005-10-10). "Total synthesis of (±)-grimaldone,epigrimaldone and o-cuparenones". Indian Journal of Chemistry (Section B). 45B: 1216–1226. doi:10.1002/chin.200738174.
- Ramachary, D. B.; Barbas, Carlos F. (2005-03-17). "Direct Amino Acid-Catalyzed Asymmetric Desymmetrization of meso-Compounds: Tandem Aminoxylation/O−N Bond Heterolysis Reactions". Organic Letters. 7 (8): 1557–1580. doi:10.1021/ol050246e.
- Suri, Jeff T.; Ramachary, D. B.; Barbas, Carlos F. (2005-03-01). "Mimicking Dihydroxy Acetone Phosphate-Utilizing Aldolases through Organocatalysis: A Facile Route to Carbohydrates and Aminosugars". Organic Letters. 7 (7): 1383–1385. doi:10.1021/ol0502533.
- Ramachary, D. B.; Anebouselvy, K.; Chowdari, Naidu S.; Barbas, Carlos F. (2004-08-06). "Direct Organocatalytic Asymmetric Heterodomino Reactions: The Knoevenagel/Diels−Alder/Epimerization Sequence for the Highly Diastereoselective Synthesis of Symmetrical and Nonsymmetrical Synthons of Benzoannelated Centropolyquinanes". The Journal of Organic Chemistry. 69 (18): 5838–5849. doi:10.1021/jo049581r.
- Ramachary, D. B.; Chowdari, Naidu S.; Barbas, Carlos F. (2003-09-15). "Organocatalytic Asymmetric Domino Knoevenagel/Diels–Alder Reactions: A Bioorganic Approach to the Diastereospecific and Enantioselective Construction of Highly Substituted Spiro[5,5]undecane‐1,5,9‐triones". Angewandte Chemie. 115 (35): 4365–4369. doi:10.1002/ange.200351916.
- Chowdari, Naidu S.; Ramachary, D. B.; Barbas, Carlos F. (2003-04-22). "Organocatalytic Asymmetric Assembly Reactions: One-Pot Synthesis of Functionalized β-Amino Alcohols from Aldehydes, Ketones, and Azodicarboxylates". Organic Letters. 5 (10): 1685–1688. doi:10.1021/ol034333n.
- Prof. D. B. Ramachary Research Laboratory Homepage, http://chemistry.uohyd.ac.in/~dbr/index.htm
- Ramachary, D. B.; Sangeeta Jain (2010-12-01). "Sequential one-pot combination of multi-component and multi-catalysis cascade reactions: an emerging technology in organic synthesis". Organic & Biomolecular Chemistry. 9 (5): 1277–1300. doi:10.1039/C0OB00611D.
- Ramachary, D. B.; Kishor, Mamillapalli; Vijayendar Reddy, Y. (2008-02-06). "Development of Pharmaceutical Drugs, Drug Intermediates and Ingredients by Using Direct Organo‐Click Reactions". European Journal of Organic Chemistr. 2008 (6): 975–993. doi:10.1002/ejoc.200701014.
- Ramachary, D. B.; Rumpa Mondal; Venkaiah, Chintalapudi (2010-05-28). "Rapid Synthesis of Functionalized Indenes, Triazoles, and Glucocorticoid Receptor Modulators by Sequential Multicatalysis Cascade Reactions". European Journal of Organic Chemistry. 2010 (17): 3205–3210. doi:10.1002/ejoc.201000220.
- Ramachary, D. B.; Shaahank, Adluri B.; Karthik, S. (2014-07-30). "An Organocatalytic Azide–Aldehyde [3+2] Cycloaddition: High‐Yielding Regioselective Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles". Angewandte Chemie International Edition. 53 (39): 10420–10424. doi:10.1002/anie.201406721.
- Ramachary, D. B.; Kishor, Mamillapalli (2008-08-12). "Direct amino acid-catalyzed cascade biomimetic reductive alkylations: application to the asymmetric synthesis of Hajos–Parrish ketone analogues". Organic & Biomolecular Chemistry. 6 (22): 4176–4187. doi:10.1039/B807999D.
- Ramachary, D. B.; Vijayendar Reddy, Y. (2009-12-02). "A General Approach to Chiral Building Blocks via Direct Amino Acid-Catalyzed Cascade Three-Component Reductive Alkylations: Formal Total Synthesis of HIV-1 Protease Inhibitors, Antibiotic Agglomerins, Brefeldin A, and (R)-γ-Hexanolide". The Journal of Organic Chemistry. 75 (1): 74–85. doi:10.1021/jo901799n.
- Ramachary, D. B.; Kishor, Mamillapalli (2010-05-07). "Direct catalytic asymmetric synthesis of highly functionalized tetronic acids/tetrahydro-isobenzofuran-1,5-diones via combination of cascade three-component reductive alkylations and Michael-aldol reactions". Organic & Biomolecular Chemistry. 8 (12): 2859–2867. doi:10.1039/C003588B.
- Ramachary, D. B.; Anif Pasha, Mohammed B.; Thirupathi, Guguloth (2017-08-07). "Organocatalytic Asymmetric Formal [3+2] Cycloaddition as a Versatile Platform to Access Methanobenzoannulenes". Angewandte Chemie International Edition. 56 (42): 12930–12934. doi:10.1002/anie.201706557.
- Ramachary, D. B.; Ramakumar, Kinthada; Narayana, Vidadala V. F. (2007-01-20). "Organocatalytic Cascade Reactions Based on Push−Pull Dienamine Platform: Synthesis of Highly Substituted Anilines". The Journal of Organic Chemistry. 72 (4): 1458–1463. doi:10.1021/jo0623639.
- Ramachary, D. B.; Ramakumar, Kinthada; Narayana, Vidadala V. F. (2008-10-10). "Amino Acid‐Catalyzed Cascade [3+2]‐Cycloaddition/Hydrolysis Reactions Based on the Push–Pull Dienamine Platform: Synthesis of Highly Functionalized NH‐1,2,3‐Triazoles". Chemistry – A European Journal. 14 (30): 9143–9147. doi:10.1002/chem.200801325.
- Ramachary, D. B.; Ramakumar, Kinthada (2011-03-09). "Direct Organocatalytic Asymmetric Approach to Baylis–Hillman‐Type Products Through a Push–Pull Dienamine Platform". European Journal of Organic Chemistry. 2011 (14): 2599–2605. doi:10.1002/ejoc.201100075.
- Ramachary, D. B.; Vijayendar Reddy, V. (2011-11-08). "Dienamine Catalysis: An Emerging Technology in Organic Synthesis". European Journal of Organic Chemistry. 2012 (5): 865–887. doi:10.1002/ejoc.201101157.
- Joseph, Jorly; Ramachary, D. B.; Jemmis, Eluvathingal D. (2006-06-21). "Electrostatic repulsion as an additional selectivity factor in asymmetric proline catalysis". Organic & Biomolecular Chemistry. 4 (14): 2685–2689. doi:10.1039/B606996G.
- Ramachary, D. B.; Madhavachary, R. B.; ShivaPrasad, M. (2012-02-10). "Observation of neighboring ortho-hydroxyl group participation in organocatalytic asymmetric sequential Michael-lactonization reactions: synthesis of highly substituted chiral spirodihydrocoumarins". Organic & Biomolecular Chemistry. 10 (30): 5825–5829. doi:10.1039/C2OB07122C.
- Ramachary, D. B.; Sakthidevi, Rajasekar B.; Shruthi, Kodambahalli S. (2012-05-30). "Asymmetric Supramolecular Catalysis: A Bio‐Inspired Tool for the High Asymmetric Induction in the Enamine‐Based Michael Reactions". Chemistry – A European Journal. 18 (26): 8008–8012. doi:10.1002/chem.201200962.
- Highlighted in News, https://www.thehansindia.com/hans/young-hans/breakthrough-findings-by-university-of-hyderabad-professor-579005
- Highlighted in News, https://www.thehindubusinessline.com/news/science/indian-chemist-has-key-chemical-reactions-named-after-him/article29900891.ece
- Fellows - Indian Academy of Sciences, https://www.ias.ac.in/describe/fellow/Ramachary,_Prof._Dhevalapally_B
- Fellows - Telangana Academy of Sciences, https://www.tasc.org.in/newly-elected-fellows.html
- Ramachary, D. B. "CRSI Bronze Medals: P. S. Mukherjee, D. B. Ramachary, T. Govindaraju, and R. Gupta / SwarnaJayanti Fellowships: S. Ghosh and C. M. Reddy / Albrecht Kossel Prize: J. Buchner / DECHEMA Early‐Career Researcher Prize: T. A. M. Gulder / Mattauch–Herzog Prize: K. Pagel / Honorary Doctorates: F. Schüth and T. J. Marks / Karl Max von Bauernfeind Medal: C. W. Kohlpaintner". Angewandte Chemie International Edition. 55 (27): 7578–7579. doi:10.1002/anie.201604544.
- List of International Advisory Board Members, Organic & Biomolecular Chemistry, https://www.rsc.org/journals-books-databases/about-journals/organic-biomolecular-chemistry/
- Previous Recipients of the BM Birla Science Prizes, https://www.birlasciencecentre.org/awards/previous-receipients-of-the-bm-birla-science-prizes/
- Previous Recipients of Anil Kumar Bose Memorial Award, http://insaindia.res.in/youngmedal.php
- Previous Recipients of Indian National Science Academy Medal for Young Scientist 2006, http://insaindia.res.in/youngmedal.php
- Ramachary, D. B. "Author profile". European Journal of Organic Chemistry. 2018 (16): 1834–1834. doi:10.1002/ejoc.201800182.
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