Dan V. Nicolau Jr.
Dan V. Nicolau Jr. | |
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| Born | Dan V. Nicolau Bucharest, Romania |
| Nationality | Romanian and Australian |
| Alma mater | University of Oxford (DPhil, BMBCh) |
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| Scientific career | |
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| Thesis | In Silico Evolution of Bacterial Chemotaxis (2009) |
| Doctoral advisor | Philip K. Maini |
Dan V. Nicolau, Jr. is a Romanian-Australian mathematician, physician and engineer.[1] He is Associate Professor of Mathematics at the Queensland University of Technology and a Future Fellow of the Australian Research Council.[2]
Education
Nicolau holds six university degrees, including in mathematics, engineering and medicine. He completed a DPhil at Balliol College, Oxford under the supervision of Philip Maini FRS and his medical degree from Green Templeton College, Oxford.[3] He went on to a Miller Fellowship at the University of California, Berkeley between 2008 and 2011 in the laboratory of M. A. R. Koehl.[4]
Research and career
Nicolau is credited with pioneering the emerging field of networks-based biocomputation that use biological agents instead of digital signals to perform complex computational tasks.[5] His approach led to the design and implementation of a biological computer that could solve the subset sum problem within a polinnomial time bound, thus creating a new computing paradigm to solve NL-complete problems effectivelly and efficiently.[6] He is also known for his work on using mathematics to understand complex biological systems by constructing computational models of mechanisms underlying protein-protein interactions on the plasma memberance and bacterial flagellar switch's coordination.[7][8] Early in the COVID-19 pademic outbreak, Nicolau constructed an epidemiological model of pandemic progression.[9][10] His research on COVID-19 also led to proposed cost-effective preventative treatments within clinical trials aimed at stopping hyperinflammation through the use of inhaled corticosteroid and budesonide. [11] Nicolau was co-founder and CEO of Altitude Medical, Inc[12].
References
- ↑ Technology (QUT), Queensland University of. "Living, breathing, reasoning computers: QUT research". QUT. Retrieved 2020-07-30.
- ↑ Layt, Stuart (2019-03-17). "Scientists look to pig brains and bacteria for computers of the future". Brisbane Times. Retrieved 2020-07-30.
- ↑ College, Green Templeton. "Dr Dan Nicolau". Green Templeton College. Retrieved 2021-03-06.
- ↑ "All Miller Fellows: By Name". miller.berkeley.edu. Retrieved 2021-03-06.
- ↑ Jr, Dan Valeriu Nicolau (2002-11-14). "Computing with the Actin-Myosin molecular motor system". Biomedical Applications of Micro- and Nanoengineering. International Society for Optics and Photonics. 4937: 219–225. doi:10.1117/12.471944.
- ↑ Nicolau, Dan V.; Lard, Mercy; Korten, Till; van Delft, Falco C. M. J. M.; Persson, Malin; Bengtsson, Elina; Månsson, Alf; Diez, Stefan; Linke, Heiner; Nicolau, Dan V. (2016-02-22). "Parallel computation with molecular-motor-propelled agents in nanofabricated networks". Proceedings of the National Academy of Sciences. 113 (10): 2591–2596. doi:10.1073/pnas.1510825113. ISSN 0027-8424. PMC 4791004. PMID 26903637.
- ↑ Nicolau, Dan V.; Burrage, Kevin; Parton, Robert G.; Hancock, John F. (2006-01-01). "Identifying Optimal Lipid Raft Characteristics Required To Promote Nanoscale Protein-Protein Interactions on the Plasma Membrane". Molecular and Cellular Biology. 26 (1): 313–323. doi:10.1128/MCB.26.1.313-323.2006. ISSN 0270-7306. PMC 1317633. PMID 16354701.
- ↑ Bai, F.; Branch, R. W.; Nicolau, D. V.; Pilizota, T.; Steel, B. C.; Maini, P. K.; Berry, R. M. (2010-02-05). "Conformational Spread as a Mechanism for Cooperativity in the Bacterial Flagellar Switch". Science. 327 (5966): 685–689. doi:10.1126/science.1182105. ISSN 0036-8075.
- ↑ Nicolau, Dan Valeriu; Hasson, Alexander; Bafadhel, Mona (2020-04-14). "Recovery Ratios Reliably Anticipate COVID-19 Pandemic Progression". medRxiv: 2020.04.09.20059824. doi:10.1101/2020.04.09.20059824.
- ↑ "COVID19". www.covidwave.org. Retrieved 2021-02-13.
- ↑ Ramakrishnan, Sanjay; Nicolau, Dan V.; Langford, Beverly; Mahdi, Mahdi; Jeffers, Helen; Mwasuku, Christine; Krassowska, Karolina; Fox, Robin; Binnian, Ian; Glover, Victoria; Bright, Stephen (2021-02-08). "Inhaled budesonide in the treatment of early COVID-19 illness: a randomised controlled trial". medRxiv: 2021.02.04.21251134. doi:10.1101/2021.02.04.21251134. ISSN 2125-1134.
- ↑ Tyler, Richard (2009-08-29). "Bob Wigley can open doors for Altitude Medical". ISSN 0307-1235. Retrieved 2020-07-30.
External links
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