Cyriel Pennartz

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Cyriel Pennartz
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Born (1963-10-07) 7 October 1963 (age 60)
Alma materUniversity of Amsterdam
Known forMemory, circadian rhythm, perception and consciousness
AwardsUnilever Research Prize
Scientific career
FieldsSystems neuroscience, cognitive neuroscience
InstitutionsUniversity of Amsterdam
Doctoral advisorFernando Lopes da Silva
Doctoral studentsMarcel de Jeu, Stefano Taverna, Rebecca Nordquist, Yvette van Dongen, Esther van Duuren, Carien Lansink, Willem Huijbers, Eunjeong Lee, Marijn van Wingerden, Martin Vinck, Henrique Cabral, Pieter Goltstein, Hemi Malkki, Jorrit Montijn, Jeroen Bos, Tara Arbab, Guido Meijer

Cyriel Pennartz (born October 7, 1963) is a Professor of neuroscience and head of the Department of Cognitive and Systems Neuroscience at the University of Amsterdam, the Netherlands.[1] He is known for his research on memory, motivation, circadian_rhythm, perception and consciousness. Pennartz’ work uses a Interdisciplinarity|multidisciplinary combination of techniques to understand the relationships between distributed neural activity and cognition, including in vivo electrophysiology and Calcium imaging, Behavioral neuroscience and Computational neuroscience.

Scientific Career

Cyriel Pennartz studied biology at Radboud University Nijmegen and University of Amsterdam with specializations in neurobiology, philosophy and computational neuroscience. He obtained his PhD degree in Neuroscience cum laude at the University of Amsterdam under the supervision of Fernando Lopes da Silva|Fernando Lopes da Silva and Henk Groenewegen|Henk Groenewegen. His PhD project and follow-up research examined the physiology and neuroplasticity|plasticity of Neural_circuit|brain circuits involved in memory and motivation, focusing on the hippocampus and ventral striatum.[2][3][4][5][6]

He proceeded to work on computational models of reinforcement learning as a postdoctoral fellow in Computational Neuroscience at the Department of Physics of Computation of the California Institute of Technology with John Hopfield.[7][8]

In 1994 he initiated research on the cellular electrophysiology of the brain’s circadian clock as tenured group leader at the Netherlands Institute for Brain Research.[9] [10] He uncovered replay of reward information in the ventral striatum during sleep, using in vivo ensemble recordings made with tetrode arrays, a technique he introduced to the Netherlands in collaboration with Bruce McNaughton and Carol Barnes at the University of Arizona (Tucson, U.S.A.).[11] [12] [13]

In 2003 he was appointed Professor in Cognitive and Systems Neuroscience at the University of Amsterdam, where he currently leads a group of ~35 people. His main goal is to advance our understanding of multisensory perception[14] [15] [16], learning and memory[17] [18] [19] [20] [21] and consciousness[22] [23] by integrating experimental, theoretical and computational approaches to neuroscience. To achieve this, the group develops novel techniques for multi-area electrophysiology[24], computer simulations of brain processes[25], analytical tools[26] [27] and causal interventions.[28] Pennartz published a theory on consciousness known as Neurorepresentationalism.[29] [30] [31] [32] [33] Using Predictive_coding|predictive processing principles[34], this theory characterizes conscious experience as a multimodally rich, spatially encompassing representation of one’s world, including one’s own body. Recently his work has been ramifying into the clinical domain, studying disorders of consciousness and memory, and into neurotechnology, developing new methods to combat consequences of stroke.

Leadership in science and education; honors and awards

At the University of Amsterdam, he co-develops curriculi and courses in Psychobiology (Bachelor), Biomedical Sciences (Bachelor), Brain and Cognitive Sciences (Master) and founded the Master track Cognitive Neurobiology and Clinical Neurophysiology. At the national level, he served for instance as co-leader of the National Science Agenda section on Brain, Behavior & Cognition (Neurolab.nl) with Prof. [Eveline Crone] and Prof. [Andrea Evers]. Since 2015, he joined the EU Future_and_Emerging_Technologies|FET Flagship Human_Brain_Project|Human Brain Project (HBP)[35] through an open call, and continues to lead HBP’s Systems and Cognitive Neuroscience Research. Representing these disciplines, he was elected member of the main governing body of HBP, the Scientific and Infrastructure Board. Pennartz received various awards, grants and honours, for example:

  • Unilever Research Prize (1986)
  • Postdoctoral Fellowship, Human Frontier Science Program Organization (1993)
  • Program Grant, Human Frontier Science Program Organization (2001)
  • VICI grant from the Netherlands Organization for Scientific Research (NWO, 2004)
  • Program Grant, Senter-Novem (Ministry of Economic Affairs) "Mouse Phenomics" (2004)
  • Project Grant, Foundation for Technical Sciences (TTW) for novel neurotechnology (2007)
  • Human Brain Project grant, FET Flagship Project, Systems and Cognitive Neuroscience Open Call (2015) and grants in subsequent grant agreements (2017, 2020).

Bibliography

  • Pennartz, C. M. A. (2015) The Brain's Representational Power - On Consciousness and the Integration of Modalities. MIT press (382pp.). ISBN: 9780262029315
  • Pennartz, C. M. A. (2021) The Code of Consciousness. How the Brain Shapes Our Reality. (Dutch: De Code van het Bewustzijn. Hoe de Hersenen Onze Werkelijkheid Vormgeven). Prometheus (349 pp.). ISBN: 9789044631913

References

  1. ↑ "Systems and Cognitive Neuroscience at the University of Amsterdam".
  2. ↑ Pennartz, C. M.; Groenewegen, H. J.; Lopes da Silva, F. H. (1994). "The nucleus accumbens as a complex of functionally distinct neuronal ensembles: an integration of behavioural, electrophysiological and anatomical data". Prog. Neurobiol. 42: 719–761. doi:10.1016/0301-0082(94)90025-6.
  3. ↑ Pennartz, C. M.; Ameerun, R. F.; Lopes da Silva, F. H. (1993). "Synaptic plasticity in an in vitro slice preparation of the rat nucleus accumbens". Eur. J. Neurosci. 5: 107–117. doi:10.1111/j.1460-9568.1993.tb00475.x.
  4. ↑ Pennartz, C. M.; Kitai, S. T. (1991). "Hippocampal inputs to identified neurons in an in vitro slice preparation of the rat nucleus accumbens: evidence for feed-forward inhibition". J. Neurosci. 11: 2838–2847. doi:10.1523/jneurosci.11-09-02838.1991.
  5. ↑ Pennartz, C. M.; Ito, R.; Verschure, P. F.; Battaglia, F. P.; Robbins, T.W. (2011). "The hippocampal-striatal axis in learning, prediction and goal-directed behavior". Trends Neurosci. 34: 548–559. doi:10.1016/j.tins.2011.08.001.
  6. ↑ Taverna, S.; Van Dongen, Y. C.; Groenewegen, H. J.; Pennartz, C. M. (2004). "Direct physiological evidence for synaptic connectivity between medium-sized spiny neurons in rat nucleus accumbens in situ". J. Neurophysiol. 91: 1111–1121. doi:10.1152/jn.00892.2003.
  7. ↑ Pennartz, C. M. A. (1997). "Reinforcement learning by Hebbian synapses with adaptive thresholds". Neuroscience. 81: 303–319. doi:10.1016/S0306-4522(97)00118-8.
  8. ↑ Pennartz, C. M. A. (1995). "The ascending neuromodulatory systems in learning by reinforcement: comparing computational conjectures with experimental findings". Brain Res Rev. 21: 219–245. doi:10.1016/0165-0173(95)00014-3.
  9. ↑ Pennartz, C. M.; De Jeu, M. T.; Bos, N. P.; Schaap, J.; Geurtsen, A. M. (2002). "Diurnal modulation of pacemaker potentials and calcium current in the mammalian circadian clock". Nature. 416: 286–290. doi:10.1038/nature728.
  10. ↑ De Jeu, M.; Pennartz, C. (2002). "Circadian modulation of GABA function in the rat suprachiasmatic nucleus: excitatory effects during the night phase". J. Neurophysiol. 87: 834–844. doi:10.1152/jn.00241.2001.
  11. ↑ Lansink, C. S.; Goltstein, P. M.; Lankelma, J. V.; McNaughton, B. L.; Pennartz, C. M. (2009). "Hippocampus leads ventral striatum in replay of place-reward information". PLoS Biology. 7: e1000173. doi:10.1371/journal.pbio.1000173.
  12. ↑ Pennartz, C. M.; Lee, E.; Verheul, J.; Lipa, P.; Barnes, C. A.; McNaughton, B. L. (2004). "The ventral striatum in off-line processing: ensemble reactivation during sleep and modulation by hippocampal ripples". J. Neurosci. 24: 6446–6456. doi:10.1523/JNEUROSCI.0575-04.2004.
  13. ↑ Lansink, C. S.; Goltstein, P. M.; Lankelma, J. V; Joosten, R. N. J. M. A.; McNaughton, B. L.; Pennartz, C. M. A. (2008). "Preferential reactivation of motivationally relevant information in the ventral striatum". J. Neurosci. 28: 6372–6382. doi:10.1523/JNEUROSCI.1054-08.2008.
  14. ↑ Meijer, G. T.; Marchesi, P.; Mejias, J. F.; Montijn, J. S.; Lansink, C. S.; Pennartz, C. M. A. (2020). "Neural correlates of multisensory detection behavior: comparison of primary and higher-order visual cortex". Cell Rep. 31: 107636. doi:10.1016/j.celrep.2020.107636.
  15. ↑ Montijn, J. S.; Goltstein, P. M.; Pennartz, C. M. (2015). "Mouse V1 population correlates of visual detection rely on heterogeneity within neuronal response patterns". eLife. 4: e10163. doi:10.7554/eLife.10163.
  16. ↑ Montijn, J. S.; Meijer, G. T.; Lansink, C. S.; Pennartz, C. M. (2016). "Population-level neural codes are robust to single-neuron variability from a multidimensional coding perspective". Cell Rep. 16: 2486–2498. doi:10.1016/j.celrep.2016.07.065.
  17. ↑ Goltstein, P. M.; Coffey, E. B.; Roelfsema, P. R.; Pennartz, C. M. (2013). "In vivo two-photon Ca2+ imaging reveals selective reward effects on stimulus-specific assemblies in mouse visual cortex". J. Neurosci. 33: 11540–11555. doi:10.1523/JNEUROSCI.1341-12.2013.
  18. ↑ Goltstein, P. M.; Meijer, G. T.; Pennartz, C. M. (2018). "Conditioning sharpens the spatial representation of rewarded stimuli in mouse primary visual cortex". eLife. 7: e37683. doi:10.7554/eLife.37683.
  19. ↑ Daselaar, S. M.; Huijbers, W.; De Jonge, M.; Goltstein, P. M.; Pennartz, C.M. (2010). "Experience-dependent alterations in conscious resting state activity following perceptuomotor learning". Neurobiol. Learn. Mem. 93: 422–427. doi:10.1016/j.nlm.2009.12.009.
  20. ↑ Lansink, C. S.; Jackson, J. C.; Lankelma, J. V.; Ito, R.; Robbins, T. W.; Everitt, B. J.; Pennartz, C. M. A. (2012). "Reward cues in space: commonalities and differences in neural coding by hippocampal and ventral striatal ensembles". J. Neurosci. 32: 12444–12459. doi:10.1523/JNEUROSCI.0593-12.2012.
  21. ↑ Van Wingerden, M.; Vinck, M.; Lankelma, J. V.; Pennartz, C. M. (2010). "Learning-associated gamma-band phase-locking of action-outcome selective neurons in orbitofrontal cortex". J. Neurosci. 30: 10025–10038. doi:10.1523/JNEUROSCI.0222-10.2010.
  22. ↑ Goltstein, P. M.; Montijn, J. S.; Pennartz, C. M. (2015). "Effects of isoflurane anesthesia on ensemble patterns of Ca2+ activity in mouse V1: reduced direction selectivity independent of increased correlations in cellular activity". PloS one. 10: e0118277. doi:10.1371/journal.pone.0118277.
  23. ↑ Olcese, U.; Bos., J. J.; Vinck, M.; Lankelma, J. V.; Van Mourik-Donga, L. B.; Schlumm, F.; Pennartz, C. M. A. (2016). "Spike-based functional connectivity in cerebral cortex and hippocampus: loss of global connectivity is coupled to preservation of local connectivity during non-REM sleep". J. Neurosci. 36: 7676–7692. doi:10.1523/JNEUROSCI.4201-15.2016.
  24. ↑ Bos, J. J.; Vinck, M.; Van Mourik-Donga, L. A.; Jackson, J. C.; Witter, M. P.; Pennartz, C. M. A. (2017). "Perirhinal firing patterns are sustained across large spatial segments of the task environment". Nat. Commun. 8: 15602. doi:10.1038/ncomms15602.
  25. ↑ Dora, S.; Pennartz, C.; Bohte, S. (2018). "A deep predictive coding network for inferring hierarchical causes underlying sensory inputs". ICANN 2018 conference submission: 457–467. doi:10.1007/978-3-030-01424-7_45.
  26. ↑ Vinck, M.; Battaglia, F. P.; Womelsdorf, T.; Pennartz, C. (2012). "Improved measures of phase-coupling between spikes and the local field potential". J. Comp. Neurosci. 33: 53–75. doi:10.1007/s10827-011-0374-4.
  27. ↑ Vinck, M.; Oostenveld, R.; Van Wingerden, M.; Battaglia, F.; Pennartz, C. M. (2011). "An improved index of phase synchronization for electrophysiological data in the presence of volume-conduction, noise and sample-size bias". Neuroimage. 55: 1548–1565. doi:10.1016/j.neuroimage.2011.01.055.
  28. ↑ Van Wingerden, M.; Vinck, M.; Tijms, V.; Ferreira, I. R. S.; Jonker, A. J.; Pennartz, C. M. A. (2012). "NMDA receptors control cue-outcome selectivity and plasticity of orbitofrontal firing patterns during associative stimulus-reward learning". Neuron. 76: 813–825. doi:10.1016/jneuron.201209.039.
  29. ↑ Pennartz, C. M. A. (2015). The brain's representational power - on consciousness and the integration of modalities. MIT Press. ISBN 9780262029315.
  30. ↑ Pennartz, C. M. A. (2018). "Consciousness, Representation, Action: the importance of being goal-directed". Trends Cogn. Sci. 22: 137–153. doi:10.1016/j.tics.2017.10.006.
  31. ↑ Olcese, U.; Oude Lohuis, M. N.; Pennartz, C. M. A. (2018). "Sensory processing across conscious and nonconscious brain states: from single neurons to distributed networks for inferential representation". Front. Syst. Neurosci. 12. doi:10.3389/vnsys.2018.00049.
  32. ↑ Pennartz, C. M. A. (2009). "Identification and integration of sensory modalities: neural basis and relation to consciousness". Conscious. Cogn. 18: 718–739. doi:10.1016/j.concog.2009.03.003.
  33. ↑ Pennartz, C. M. A. (2021). De code van het bewustzijn (The code of consciousness; in Dutch). Prometheus. ISBN 9789044631913.
  34. ↑ Pennartz, C. M. A.; Dora, S.; Muckli, L.; Lorteije, J. A. M. (2019). "Towards a unified view on pathways and functions of neural recurrent processing". Trends Neurosci. 42: 589–603. doi:10.1016/j.tins.2019/07.005.
  35. ↑ Amunts, K.; Knoll, A. C.; Lippert, T.; Pennartz, C. M. A.; Ryvlin, P.; Destexhe, A.; Jirsa, V. K.; D'Angelo, E.; Bjaalie, J. G. (2019). "The Human Brain Project - synergy between neuroscience, computing, informatics, and brain-inspired technologies". PLoS Biology. 17: e30000344. doi:10.1371/journal.pbio.30000344.

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