Csaba Pal

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Csaba Pal
Csaba Pal.png
Born (1975-03-27) March 27, 1975 (age 48)
Budapest, Hungary
EducationMasters in Biology
Doctor of Philosophy
Doctor of Science
Alma materEötvös Loránd University, Budapest
Hungarian Academy of Sciences
Scientific adviser
AwardsIgnaz Lieben Award
Szent-György Talentum Prize
Bolyai Prize

Csaba Pal (born March 27, 1975)[1][2] is a Hungarian biologist at the Biological Research Centre (BRC)[3] in Szeged Hungary. His laboratory is part of the Synthetic and Systems Biology Unit at BRC.[4][5] His research is at the interface of evolution, antibiotic resistance and genome engineering[6][7] and has published over 70 scientific publications in these areas.[8][9]


Csaba Pal completed his Masters in Biology at Eötvös Loránd University, Budapest, in 1998.[2][10] Four years later he was awarded a Doctor of Philosophy degree from the Eötvös Loránd University, Budapest in 2002.[2][10] In 2018 he received a Doctor of Science degree from the Hungarian Academy of Sciences.[2] Csaba Pal spent several years abroad with scholarships. He had the opportunity to research in Bath,[11] Oxford, Heidelberg and Italy.[2][10] Prior to his return to Hungary in 2008, he worked as a visiting scientist at the University of Trento.[2][10]

Career and Research

Csaba Pal works on fundamental and applied problems in the evolution of genomes networks and antibiotic resistance.[6] To achieve these goals, he develops methods in systems biology, computational metabolic modelling and genome engineering.

Genome evolution

In 2001, Csaba Pal and colleagues demonstrated that highly expressed genes in yeast evolve slowly.[12] Later, they argued that evolutionary rate of a protein is predominantly influenced by its expression level rather than functional importance. This research has contributed to a paradigmatic shift in the field of protein evolution.[13][14] Balazs Papp, Csaba Pal, and Laurence Hurst studied molecular mechanisms underlying dosage sensitivity.[15] They specifically tested what is now known as the dosage balance hypothesis.[16] The hypothesis offers a synthesis on seemingly unrelated problems such as the evolution of dominance, gene duplicability and co-evolution of protein complex subunits. More recently, the Pal lab explored the consequences of compensatory adaptation on gene content evolution.[17] It is well known that while core cellular processes are generally conserved during evolution, the underlying genes differ somewhat between related species. They demonstrated that gene loss initiates adaptive genomic changes that rapidly restores fitness, but this process has substantial pleiotropic effects on cellular physiology and evolvability upon environmental change.[18]

Network evolution

The Pal lab has also contributed to the nascent field of evolutionary systems biology.[19] Their research focused on understanding the extent to which evolution is predictable at the molecular level. Using genome-scale metabolic network modeling combined with experimental tools they studied key issues in evolution, such as mutational robustness,[20] horizontal gene transfer,[21] genome reduction,[22] epistasis,[23][24] promiscuous enzyme reactions,[25] and complex adaptations.[26]

Awards and honours

Csaba Pal received several domestic and international awards, including the Ignaz Lieben Award (2009),[27][28] Szent-György Talentum Prize (2014),[29] and the Bolyai Prize (2015).[30][31][32][33] In 2016, Csaba Pal became member of Academiae Europae.[34] In 2017 he was selected as EMBO (European Molecular Biology Organization) member.[35][36] and in 2018, became a member of the FEMS. (Federation of European Microbiological Society)[7]

External Links


  1. "BRC Csaba PÁL D.Sc". www.brc.hu. Retrieved 29 January 2020.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 "BRC Csaba PÁL CV" (PDF). Retrieved 29 January 2020.
  3. "BRC". www.brc.hu. Retrieved 28 January 2020.
  4. "BRC Synthetic and Systems Biology Unit". www.brc.hu. Retrieved 29 January 2020.
  5. "Csaba Pál Laboratory". group.szbk.u-szeged.hu. Retrieved 28 January 2020.
  6. 6.0 6.1 "New members greeted in Heidelberg". EMBO. Retrieved 19 December 2018.
  7. 7.0 7.1 "FEMS Expert: Dr Csaba Pal". FEMS. Retrieved 29 January 2020.
  8. "Magyar Tudományos Művek Tára". m2.mtmt.hu. Retrieved 31 January 2020.
  9. "Csaba Pal - Google Scholar Citations". scholar.google.hu. Retrieved 31 January 2020.
  10. 10.0 10.1 10.2 10.3 "Academy of Europe: CV". www.ae-info.org. Retrieved 29 January 2020.
  11. "Students and post-docs past and present". people.bath.ac.uk. Retrieved 28 January 2020.
  12. Hurst, Laurence D.; Papp, Balázs; Pál, Csaba (June 2001). "Highly Expressed Genes in Yeast Evolve Slowly". Genetics. 158 (2): 927–931.
  13. Zhang, Jianzhi; Yang, Jian-Rong (2015). "Determinants of the rate of protein sequence evolution". Nature Reviews Genetics. 16 (7): 409–420. doi:10.1038/nrg3950. PMC 4523088. PMID 26055156.
  14. Koonin, E. V. (2011). "Are there laws of genome evolution?". Plos Computational Biology. 7 (8): e1002173. doi:10.1371/journal.pcbi.1002173. PMC 3161903. PMID 21901087.
  15. Papp, Balázs; Pál, Csaba; Hurst, Laurence D. (July 2003). "Dosage sensitivity and the evolution of gene families in yeast". Nature. 424 (6945): 194–197. doi:10.1038/nature01771. ISSN 1476-4687. Retrieved 10 July 2003.
  16. Birchler, J. A.; Veitia, R. A. (20 August 2012). "Gene balance hypothesis: Connecting issues of dosage sensitivity across biological disciplines". Proceedings of the National Academy of Sciences. 109 (37): 14746–14753. doi:10.1073/pnas.1207726109. ISSN 0027-8424. Retrieved Sep 11, 2012.
  17. Szamecz, Béla; Boross, Gábor; Kalapis, Dorottya; Kovács, Károly; Fekete, Gergely; Farkas, Zoltán; Lázár, Viktória; Hrtyan, Mónika; Kemmeren, Patrick; Groot Koerkamp, Marian J. A.; Rutkai, Edit; Holstege, Frank C. P.; Papp, Balázs; Pál, Csaba (2014). "The Genomic Landscape of Compensatory Evolution". PLOS Biology. 12 (8): e1001935. doi:10.1371/journal.pbio.1001935. PMC 4144845. PMID 25157590.
  18. Szamecz, Béla; Boross, Gábor; Kalapis, Dorottya; Kovács, Károly; Fekete, Gergely; Farkas, Zoltán; Lázár, Viktória; Hrtyan, Mónika; Kemmeren, Patrick; Groot Koerkamp, Marian J. A.; Rutkai, Edit; Holstege, Frank C. P.; Papp, Balázs; Pál, Csaba (2014). "The Genomic Landscape of Compensatory Evolution". PLOS Biology. 12 (8): e1001935. doi:10.1371/journal.pbio.1001935. PMC 4144845. PMID 25157590.
  19. Papp, Balázs; Notebaart, Richard A.; Pál, Csaba (September 2011). "Systems-biology approaches for predicting genomic evolution". Nature Reviews Genetics. 12 (9): 591–602. doi:10.1038/nrg3033. ISSN 1471-0064. Retrieved 2 August 2011.
  20. Papp, Balázs; Pál, Csaba; Hurst, Laurence D. (June 2004). "Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast". Nature. 429 (6992): 661–664. doi:10.1038/nature02636. ISSN 1476-4687. Retrieved 10 June 2004.
  21. Pál, Csaba; Papp, Balázs; Lercher, Martin J. (December 2005). "Adaptive evolution of bacterial metabolic networks by horizontal gene transfer". Nature Genetics. 37 (12): 1372–1375. doi:10.1038/ng1686. ISSN 1546-1718. Retrieved 20 November 2005.
  22. Pál, Csaba; Papp, Balázs; Lercher, Martin J.; Csermely, Péter; Oliver, Stephen G.; Hurst, Laurence D. (March 2006). "Chance and necessity in the evolution of minimal metabolic networks". Nature. 440 (7084): 667–670. doi:10.1038/nature04568. ISSN 1476-4687. Retrieved 30 March 2006.
  23. Harrison, Richard; Papp, Balázs; Pál, Csaba; Oliver, Stephen G.; Delneri, Daniela (13 February 2007). "Plasticity of genetic interactions in metabolic networks of yeast". Proceedings of the National Academy of Sciences. 104 (7): 2307–2312. doi:10.1073/pnas.0607153104. ISSN 0027-8424. Retrieved February 13, 2007.
  24. Szappanos, Balázs; Kovács, Károly; Szamecz, Béla; Honti, Frantisek; Costanzo, Michael; Baryshnikova, Anastasia; Gelius-Dietrich, Gabriel; Lercher, Martin J.; Jelasity, Márk; Myers, Chad L.; Andrews, Brenda J.; Boone, Charles; Oliver, Stephen G.; Pál, Csaba; Papp, Balázs (July 2011). "An integrated approach to characterize genetic interaction networks in yeast metabolism". Nature Genetics. 43 (7): 656–662. doi:10.1038/ng.846. ISSN 1546-1718. Retrieved 29 May 2011.
  25. Notebaart, Richard A.; Szappanos, Balázs; Kintses, Bálint; Pál, Ferenc; Györkei, Ádám; Bogos, Balázs; Lázár, Viktória; Spohn, Réka; Csörgő, Bálint; Wagner, Allon; Ruppin, Eytan; Pál, Csaba; Papp, Balázs (12 August 2014). "Network-level architecture and the evolutionary potential of underground metabolism". Proceedings of the National Academy of Sciences. 111 (32): 11762–11767. doi:10.1073/pnas.1406102111. ISSN 0027-8424. Retrieved August 12, 2014.
  26. Szappanos, Balázs; Fritzemeier, Jonathan; Csörgő, Bálint; Lázár, Viktória; Lu, Xiaowen; Fekete, Gergely; Bálint, Balázs; Herczeg, Róbert; Nagy, István; Notebaart, Richard A.; Lercher, Martin J.; Pál, Csaba; Papp, Balázs (20 May 2016). "Adaptive evolution of complex innovations through stepwise metabolic niche expansion". Nature Communications. 7 (1): 1–10. doi:10.1038/ncomms11607. ISSN 2041-1723. Retrieved 20 May 2016.
  27. "Lieben Prize". Wikipedia. 17 January 2020. Retrieved 29 January 2020.
  28. "Csaba Pal". stipendien.oeaw.ac.at. Retrieved 17 November 2008.
  29. "Szent-Györgyi Talents Award". www.nobel-szeged.hu. Retrieved 29 January 2020.
  30. "Pál Csaba biológus a Bolyai-díjas 2015-ben". Hivatalos weboldalra költözött a Bolyai-díj. Retrieved 17 May 2015.
  31. "Bolyai-díj – 2015". National Geographic (in magyar). Retrieved 18 May 2015.
  32. "Biologist Csaba Pál is awarded this year's Bolyai Prize". www.t-systems.hu. Retrieved 18 May 2015.
  33. "Pál Csaba biológus kapta az idei Bolyai-díjat". hirado.hu (in magyar). Retrieved 17 May 2015.
  34. "Academy of Europe: P%C 3%A 1 l Csaba". www.ae-info.org. Retrieved 28 January 2020.
  35. Jukic, Igor. "EMBO welcomes 65 new members". EMBO. Retrieved 16 June 2017.
  36. "Find people in the EMBO Communities". people.embo.org. Retrieved 28 January 2020.

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