Axel Schumacher

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Dr. Axel Schumacher
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Born (1969-06-14) June 14, 1969 (age 52)
Kreuztal, Germany
NationalityGerman
CitizenshipGermany
EducationPhD in Biology
Alma materUniversity of Cologne
OccupationResearcher
Websitehttps://HLTH.network

Dr. Axel Schumacher, born (1969-06-14) June 14, 1969 (age 52), is a German epigenetics researcher. He invented the first microarray technologies for epigenetic biomarker discovery, developed the ‘epigenetic theory of aging’ with his research leading to the worldwide first proof of whole genome epigenetic abnormalities in Alzheimer's disease.

Alongside his work as a scientist he is a published author, a futurologist and as of July 2017, CEO and co-founder of the HLTH.network.

Education and Early Life

Dr. Schumacher was born in Kreuztal/Germany in 1969. Schumacher graduated with a PhD in Biology from University of Cologne under the supervision of Rober Koch Prize laureate Prof. Walter Doerfler in 2002.

Career

Epigenetics

Schumacher started his career in epigenetics as a visiting researcher at the laboratory of Wolf Reik at the Babraham Institute near Cambridge, England working on DNA methylation and genomic imprinting.

During his career he made several breakthrough discoveries including, how genomic imprinting is regulated by DNA methylation [1] [2], the effect of in vitro manipulation on imprinted regions in the genome[3], the first description of ‘epigenetic SNPs’[4], the invention of single-cell epigenomics[5], with his research leading to the world's first proof of whole genome epigenetic abnormalities in Alzheimer's disease[6], indicating that the main predisposing factors for Alzheimer’s disease, PSEN1|PSEN and Apolipoprotein E|APOE, have a high interindividual variation in humans, which could indicate they are prone to epigenetic abnormalities.

Schumacher invented the technology of ‘epigenetic microarrays’[7], a technology that transformed the research field and led to hundreds of research discoveries across the world, including the the worldwide the first proof of whole genome epigenetic changes in schizophrenia and bipolar disorder[8].

In 2010, Schumacher proposed the ‘epigenetic theory of aging’ a new unifying model of aging and the development of complex diseases, incorporating classical aging theories and epigenetics[9]. His work on epigenetic drift and age-related epigenetic changes in mice and humans[10][11] laid the foundation to the epigenetic clock theory of aging.

Blockchain Technology

Dr. Schumacher at GES Summit 2019 with former US secretary of State Mike Pompeo, Mayor Pauline Krikke, and Dutch Prime Minister Mark Rutte Schumacher at GES Summit 2019 with former US secretary of State Mike Pompeo, Mayor Pauline Krikke, and Dutch Prime Minister Mark Rutte Dr. Schumacher is one of the pioneers of blockchain. In July 2017, Dr. Axel Schumacher co-founded HLTH.network alongside George Church (geneticist)|Dr. George Church and Gourish Singla with the aim of developing the world's first base layer protocol for global health data. Currently, Axel operates as HLTH.network's CEO.

He is the author of the popular 'Blockchain & Healthcare Strategy Guide'[12]. Dr. Schumacher is also a researcher at the Blockchain Research Institute in Toronto, the world’s leading Blockchain Think Tank.

Other Work

During the 1990’s, Schumacher worked as comic book author and artist[13]. Among others he worked alongside famous artists such as Russian painter Oleg Yudin[14] on titles such as 'High Speed'[15] and on various stories for the American science fiction and fantasy comics magazine Heavy Metal (magazine)|Heavy Metal.

Late Night Science Show

Since 2020, Axel has been the host of the popular Late Night Science Show. He has had many prestigious guests such as Charles Hoskinson, Ben Goertzel and George Church (geneticist)|George Church. The podcast discusses the "wonders of science"[16] and spreads the "word about the way of acquiring knowledge that has characterized our species development since the 17th century."[17]

References

  1. Schumacher, Axel; Buiting, Karin; Zeschnigk, Michael; Doerfler, Walter; Horsthemke, Bernhard (August 1998). "Methylation analysis of the PWS/AS region does not support an enhancer-competition model". Nature Genetics. 19 (4): 324–325. doi:10.1038/1211. ISSN 1546-1718.
  2. Schumacher, A.; Koetsier, P. A.; Hertz, J.; Doerfler, W. (2000-12-01). "Epigenetic and genotype-specific effects on the stability of de novo imposed methylation patterns in transgenic mice". The Journal of Biological Chemistry. 275 (48): 37915–37921. doi:10.1074/jbc.M004839200. ISSN 0021-9258. PMID 10954710.
  3. Schumacher, Axel; Doerfler, Walter (2004). "Influence of in vitro manipulation on the stability of methylation patterns in the Snurf/Snrpn-imprinting region in mouse embryonic stem cells". Nucleic Acids Research. 32 (4): 1566–1576. doi:10.1093/nar/gkh322. ISSN 1362-4962. PMID 15004243.
  4. Schumacher, Axel; Friedrich, Patricia; Diehl-Schmid, Janine; Ibach, Bernd; Eisele, Tamara; Laws, Simon M.; Förstl, Hans; Kurz, Alexander; Riemenschneider, Matthias (November 2007). "No association of chromatin-modifying protein 2B with sporadic frontotemporal dementia". Neurobiology of Aging. 28 (11): 1789–1790. doi:10.1016/j.neurobiolaging.2006.07.016. ISSN 1558-1497. PMID 16979267.
  5. Kantlehner, Martin; Kirchner, Roland; Hartmann, Petra; Ellwart, Joachim W.; Alunni-Fabbroni, Marianna; Schumacher, Axel (April 2011). "A high-throughput DNA methylation analysis of a single cell". Nucleic Acids Research. 39 (7): e44. doi:10.1093/nar/gkq1357. ISSN 0305-1048. PMC 3074158. PMID 21266484.
  6. Wang, Sun-Chong; Oelze, Beatrice; Schumacher, Axel (2008-07-16). "Age-specific epigenetic drift in late-onset Alzheimer's disease". PloS One. 3 (7): e2698. doi:10.1371/journal.pone.0002698. ISSN 1932-6203. PMC 2444024. PMID 18628954.
  7. Schumacher, Axel; Kapranov, Philipp; Kaminsky, Zachary; Flanagan, James; Assadzadeh, Abbas; Yau, Patrick; Virtanen, Carl; Winegarden, Neil; Cheng, Jill; Gingeras, Thomas; Petronis, Arturas (2006). "Microarray-based DNA methylation profiling: technology and applications". Nucleic Acids Research. 34 (2): 528–542. doi:10.1093/nar/gkj461. ISSN 1362-4962. PMC 1345696. PMID 16428248.
  8. Mill, Jonathan; Tang, Thomas; Kaminsky, Zachary; Khare, Tarang; Yazdanpanah, Simin; Bouchard, Luigi; Jia, Peixin; Assadzadeh, Abbas; Flanagan, James; Schumacher, Axel; Wang, Sun-Chong (March 2008). "Epigenomic profiling reveals DNA-methylation changes associated with major psychosis". American Journal of Human Genetics. 82 (3): 696–711. doi:10.1016/j.ajhg.2008.01.008. ISSN 1537-6605. PMC 2427301. PMID 18319075.
  9. Schumacher, Axel. Handbook of Epigenetics: The New Molecular and Medical Genetics. pp. 405–422. ISBN 978-0123757098.
  10. Schumacher, Axel (Jan 2009). "An epigenetic clock: Anticorrelation & DNA methylation as biomarker for aging". ResearchGate.
  11. Wang, Sun-Chong; Oelze, Beatrice; Schumacher, Axel (2008-07-16). "Age-specific epigenetic drift in late-onset Alzheimer's disease". PloS One. 3 (7): e2698. doi:10.1371/journal.pone.0002698. ISSN 1932-6203. PMC 2444024. PMID 18628954.
  12. "Blockchain & Healthcare - 2017 Strategy Guide released". www.linkedin.com. Retrieved 2021-08-17.
  13. "Axel Schumacher". lambiek.net. Retrieved 2021-08-17.
  14. "High Speed (2000) issue OGN SC vol. 01". comicbookcollect.com. Retrieved 2021-08-17.
  15. "Oleg Yudin". lambiek.net. Retrieved 2021-08-17.
  16. "Late Night Science - YouTube". www.youtube.com. Retrieved 2021-08-17.
  17. "Late Night Science - YouTube". www.youtube.com. Retrieved 2021-08-17.

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