Abdul Waseh Basit

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Abdul W. Basit
Alma mater
  • University of Bath (BPharm)
  • The School of Pharmacy
  • University of London (PhD)
Known for3D printing of pharmaceuticals

Drug delivery

Gastroenterology
Scientific career
FieldsPharmaceutics
InstitutionsUniversity College London
Doctoral advisorJohn Michael Newton
Add a Photo
NationalityBritish
CitizenshipEngland

Abdul Waseh Basit is a British pharmacist and Professor of Pharmaceutics at University College London.[1]. He is also the founder of two pharmaceutical spin-out companies from UCL, FabRx Ltd[2] and Intract Pharma[3]. Basit is known for his scientific research in gastroenterology, oral drug delivery, and pharmaceutical 3D printing[4][5][6].

Background

Basit graduated with a First Class Honours degree in Pharmacy in 1993 from the University of Bath, and undertook his pharmacy pre-registration training at Pfizer Pharmaceuticals, becoming a registered pharmacist in 1994[7][8]. He joined the School of Pharmacy, University of London (now UCL School of Pharmacy) in 1994 where he completed his PhD in Pharmaceutics and was appointed Professor in Pharmaceutics in 2010.

Research & career

Basit leads a research group that investigates the oral delivery of biologicals[9][10], sex differences in the effects of excipients on drug absorption[11][12], metabolic potential of the intestinal microbiota on drug behaviour[13][14], and the development of modern pharmaceutical manufacturing techniques using three-dimensional (3D) printing[15][16][17]. His group pioneered the use of fused deposition modelling (FDM) 3D printing[17] and selective laser sintering (SLS) 3D printing[15] for producing pharmaceutical formulations. Basit holds several granted patents[18][19][20][21] and has invented a number of advanced drug delivery technologies that have been translated into the clinic, including PHLORAL™, DuoCoat™, Opticore™ and Soteria™[22]. To date, Basit has attracted £100 million in investments as a principal investigator (PI) or co-PI[23]. In 2016, Basit was appointed the European editor of the International Journal of Pharmaceutics[24]. He is also an editorial board member of Drug Development and Industrial Pharmacy[25], AAPS PharmSciTech[26], Journal of Drug Delivery Science and Technology[27], and Pharmaceutics (journal)[28].

Entrepreneurship

FabRx

In 2014, Basit founded FabRx with Simon Gaisford, Alvaro Goyanes Goyanes, and Bill Lindsay. FabRx is a biotechnology company specialising in the development of 3D printing technology for medicines and medical devices. In 2017, FabRx was awarded the TCT Best Start-Up Award[29]. In 2019, FabRx was awarded over £600,000 from Innovate UK to develop a 3D printer for the production of personalised medicines[30]. In September 2019, FabRx completed a clinical study using its Printlets™ technology to treat children with maple syrup urine disease[31].

Intract Pharma

In 2016, Basit founded Intract Pharma with Vipul Yadav and Bill Lindsay. Intract Pharma is a pharmaceutical company that provides licensable technologies for targeted delivery in the gastrointestinal tract. In 2018, Intract Pharma was awarded £1.4 million from Innovate UK to develop a scalable manufacturing process for novel oral antibody products using its Soteria™ technology[32][33]. In the same year, Intract Pharma received an award from the Bill & Melinda Gates Foundation to fund investigation of its Soteria™ technology as a means to stabilise orally-administered therapeutic antibodies to fight against diarrhoeal diseases in children in the developing world[34]. In December 2018, in collaboration with Tillots Pharma AG, Intract Pharma launched Yaldigo®/Asacol 1600[35], a medicine used for the treatment of ulcerative colitis.

Awards & Honours

Selected awards received by Basit include:

  • 2004 American Association of Pharmaceutical Scientists Young Investigator Award in Pharmaceutics and Pharmaceutical Technology.[36]
  • 2014 Academy of Pharmaceutical Sciences AstraZeneca Award.[37]
  • 2017 Academy of Pharmaceutical Sciences Science Chairman.[38]
  • 2019 GlaxoSmithKline Innovative Science Award.[39]
  • 2019 Web of Science Group World’s Most Highly Cited Researchers.[40]

Books

  • 3D Printing of Pharmaceuticals[41]

References

  1. ↑ UCL (2018-04-25). "Professor Abdul Basit". UCL School of Pharmacy. Retrieved 2020-01-07.
  2. ↑ "Abdul Basit". FabRx. Retrieved 2020-01-07.
  3. ↑ "About Us". Intract Pharma. Retrieved 2020-01-07.
  4. ↑ "Abdul Basit - Google Scholar Citations". scholar.google.co.uk. Retrieved 2020-01-07.
  5. ↑ "Abdul W Basit, Author at ONdrugDelivery". ONdrugDelivery. Retrieved 2020-01-07.
  6. ↑ "Abdul Basit". scholar.google.com. Retrieved 2020-10-14.
  7. ↑ "Professor Abdul Basit". www.ucl.ac.uk. Retrieved 2020-01-07.
  8. ↑ "Joint Pharmaceutical Analysis Group". www.jpag.org. Retrieved 2020-01-07.
  9. ↑ Yadav, Vipul; Varum, Felipe; Bravo, Roberto; Furrer, Esther; Basit, Abdul W. (2016-04-11). "Gastrointestinal stability of therapeutic anti-TNF α IgG1 monoclonal antibodies". International Journal of Pharmaceutics. 502 (1): 181–187. doi:10.1016/j.ijpharm.2016.02.014. ISSN 0378-5173. PMID 26892815.
  10. ↑ Yadav, Vipul; Varum, Felipe; Bravo, Roberto; Furrer, Esther; Bojic, Daniela; Basit, Abdul W. (2016-10-01). "Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets". Translational Research. 176: 38–68. doi:10.1016/j.trsl.2016.04.009. ISSN 1931-5244. PMID 27220087.
  11. ↑ Freire, Ana C.; Basit, Abdul W.; Choudhary, Rahul; Piong, Chee W.; Merchant, Hamid A. (2011-08-30). "Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery". International Journal of Pharmaceutics. 415 (1): 15–28. doi:10.1016/j.ijpharm.2011.04.069. ISSN 0378-5173. PMID 21640175.
  12. ↑ Mai, Yang; Dou, Liu; Madla, Christine M.; Murdan, Sudaxshina; Basit, Abdul W. (May 2019). "Sex-Dependence in the Effect of Pharmaceutical Excipients: Polyoxyethylated Solubilising Excipients Increase Oral Drug Bioavailability in Male but Not Female Rats". Pharmaceutics. 11 (5): 228. doi:10.3390/pharmaceutics11050228. PMC 6571596. PMID 31083453.
  13. ↑ Sousa, Tiago; Paterson, Ronnie; Moore, Vanessa; Carlsson, Anders; Abrahamsson, Bertil; Basit, Abdul W. (2008-11-03). "The gastrointestinal microbiota as a site for the biotransformation of drugs". International Journal of Pharmaceutics. 363 (1): 1–25. doi:10.1016/j.ijpharm.2008.07.009. ISSN 0378-5173. PMID 18682282.
  14. ↑ Wilson, Peter J; Basit, Abdul W (2005-08-26). "Exploiting gastrointestinal bacteria to target drugs to the colon: An in vitro study using amylose coated tablets". International Journal of Pharmaceutics. Festschrift in Honour of the 65th Birthday of Professor A.T. Florence. 300 (1): 89–94. doi:10.1016/j.ijpharm.2005.05.010. ISSN 0378-5173. PMID 16023805.
  15. ↑ 15.0 15.1 Fina, Fabrizio; Goyanes, Alvaro; Gaisford, Simon; Basit, Abdul W. (2017-08-30). "Selective laser sintering (SLS) 3D printing of medicines". International Journal of Pharmaceutics. 529 (1): 285–293. doi:10.1016/j.ijpharm.2017.06.082. ISSN 0378-5173. PMID 28668582.
  16. ↑ Goyanes, Alvaro; Buanz, Asma B. M.; Basit, Abdul W.; Gaisford, Simon (2014-12-10). "Fused-filament 3D printing (3DP) for fabrication of tablets". International Journal of Pharmaceutics. 476 (1): 88–92. doi:10.1016/j.ijpharm.2014.09.044. ISSN 0378-5173. PMID 25275937.
  17. ↑ 17.0 17.1 Goyanes, Alvaro; Chang, Hanah; Sedough, Daniel; Hatton, Grace B.; Wang, Jie; Buanz, Asma; Gaisford, Simon; Basit, Abdul W. (2015-12-30). "Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing". International Journal of Pharmaceutics. 496 (2): 414–420. doi:10.1016/j.ijpharm.2015.10.039. ISSN 0378-5173. PMID 26481468.
  18. ↑ [1], "Colonic drug delivery formulation", issued 2020-02-24 
  19. ↑ [2], "Solid dosage forms comprising an enteric coating with accelerated drug release", issued 2012-09-05 
  20. ↑ [3], "Delayed release drug formulation", issued 2016-09-16 
  21. ↑ [4], "Apparatus and method for testing medicaments", issued 2016-12-28 
  22. ↑ "Abdul Waseh Basit Inventions, Patents and Patent Applications - Justia Patents Search". patents.justia.com. Retrieved 2020-01-07.
  23. ↑ UCL (2018-04-25). "Professor Abdul Basit". UCL School of Pharmacy. Retrieved 2020-01-30.
  24. ↑ International Journal of Pharmaceutics Editorial Board.
  25. ↑ "Drug Development and Industrial Pharmacy". www.tandfonline.com. Retrieved 2020-01-07.
  26. ↑ "Meet the Editorial Advisory Board of AAPS PharmSciTech". springer.com. Retrieved 2020-01-07.
  27. ↑ Journal of Drug Delivery Science and Technology Editorial Board.
  28. ↑ "Pharmaceutics". www.mdpi.com. Retrieved 2020-01-07.
  29. ↑ Davies, Sam (2017-12-04). "FabRx launches Kickstarter campaign as it looks to 3D print medicine for children". TCT Magazine. Retrieved 2020-01-07.
  30. ↑ "FabRx Awarded Innovate UK Grant to Design the World's First Personalised Medicine 3D Printer". FabRx. 2019-04-14. Retrieved 2020-01-07.
  31. ↑ "FabRx performs the first clinical study using personalised 3D printed dosage forms to treat children with a rare metabolic disease". FabRx. 2019-09-03. Retrieved 2020-01-07.
  32. ↑ UCL (2019-03-07). "Intract awarded Innovate UK grant to make oral antibody formulation using Soteria® technology". UCL School of Pharmacy. Retrieved 2020-01-07.
  33. ↑ "Intract Pharma awarded £1.4m grant to develop antibodies". EPM Magazine. 2018-12-28. Retrieved 2020-01-07.
  34. ↑ "Intract Pharma to join fight against diarrhoeal diseases in children in the developing world". Intract Pharma. 2018-11-23. Retrieved 2020-01-07.
  35. ↑ "Intract Pharma announces market launch of a first Phloral® colon-targeting product". Intract Pharma. 2019-03-27. Retrieved 2020-01-07.
  36. ↑ "Our Advisors". Biokier. Retrieved 2020-01-07.
  37. ↑ UCL (2014-08-21). "Professor Abdul Basit receives Academy of Pharmaceutical Sciences Award". UCL School of Pharmacy. Retrieved 2020-01-07.
  38. ↑ Andy (2019-02-21). "APS PharmSci Conference Blog". The Academy of Pharmaceutical Sciences. Retrieved 2020-01-07.
  39. ↑ Andy. "Academy Awards Application". The Academy of Pharmaceutical Sciences. Retrieved 2020-01-07.
  40. ↑ UCL (2019-11-20). "Three Pharmacy academics listed amongst World's Most Influential Researchers by Web of Science". UCL School of Pharmacy. Retrieved 2020-01-07.
  41. ↑ Basit, Abdul; Gaisford, Simon, eds. (2018). 3D Printing of Pharmaceuticals. AAPS Advances in the Pharmaceutical Sciences Series. Springer International Publishing. ISBN 978-3-319-90754-3.

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