Kuan Wang
Kuan Wang is a Chinese-American biochemist who has made major contributions to muscle biochemistry and cell biology. After receiving a bachelor's degree in chemistry from Taiwan National University, he came to the United States for graduate study and earned a Ph.D. in molecular biophysics and biochemistry from Yale University[1] under the guidance of Frederic M. Richards.[2] He was an NIH Postdoctoral Fellow (1974–1976)[3] at the University of California, San Diego, in the laboratory of Seymour Jonathan Singer.[4][5] In 1977 he joined the Department of Chemistry at the University of Texas at Austin as assistant professor.[6] During his early years at UT, Wang and his co-workers discovered two previously unrecognized high molecular weight proteins of myofibrils, Titin[7] and Nebulin,[8] which fundamentally changed our understanding of muscle sarcomeres.[9]
At UT Wang was promoted to associate professor in 1984 and professor in 1989.[6] During this period, Wang and his coworkers extended and ramified their findings on the structures of Titin and Nebulin and how they function within the sarcomere.[9]
In 1997, Wang moved to the National Institutes of Health where he became Chief of the Laboratory of Physical Biology in the National Institute of Arthritis, Musculoskeletal and Skin Diseases, then becoming Chief of the Laboratory of Muscle Biology in 2002.[3] At NIH, Wang's interests and responsibilities broadened to include a broad range of biophysical methods and nanomedicine.[10]
In 2011, after retiring from the NIH, Wang returned to Taiwan where he served the Academia Sinica in several capacities, including Director of the Chemistry Institute, Distinguished Research Fellow in Biological Chemistry, and Director of the Nanomedicine Program[3] until amyotrophic lateral sclerosis forced his retirement. Despite his physical disability, Wang continues to hold (2015-) a University Chair Professorship in the College of Biomedical Engineering of Taipei Medical University[11] through which he continues to mentor young scientists and to collaborate in ongoing research.
References
- ↑ Wang, Kuan (1974). An Approach to Nearest Neighbor Analysis of Membrane Proteins Application to the Human Erythrocyte Membrane of a Method Employing Cleavable Crosslinkages.
- ↑ Wang, Kuan; Richards, Frederic M. (December 1974). "An Approach to Nearest Neighbor Analysis of Membrane Proteins". Journal of Biological Chemistry. 249 (24): 8005–8018. doi:10.1016/s0021-9258(19)42065-6. ISSN 0021-9258.
- ↑ 3.0 3.1 3.2 "中央研究院物理研究所". www.phys.sinica.edu.tw. Retrieved 2021-12-18.
- ↑ Wang, K.; Ash, J. F.; Singer, S. J. (1975-11-01). "Filamin, a new high-molecular-weight protein found in smooth muscle and non-muscle cells". Proceedings of the National Academy of Sciences. 72 (11): 4483–4486. doi:10.1073/pnas.72.11.4483. ISSN 0027-8424.
- ↑ Wang, K.; Singer, S. J. (1977-05-01). "Interaction of filamin with f-actin in solution". Proceedings of the National Academy of Sciences. 74 (5): 2021–2025. doi:10.1073/pnas.74.5.2021. ISSN 0027-8424.
- ↑ 6.0 6.1 "UT-Austin Chemistry faculty list, 1883-2018" (PDF).
{{cite web}}: CS1 maint: url-status (link) - ↑ Wang, K.; McClure, J.; Tu, A. (1979-08-01). "Titin: major myofibrillar components of striated muscle". Proceedings of the National Academy of Sciences. 76 (8): 3698–3702. doi:10.1073/pnas.76.8.3698. ISSN 0027-8424.
- ↑ Wang, K.; Williamson, C. L. (1980-06-01). "Identification of an N2 line protein of striated muscle". Proceedings of the National Academy of Sciences. 77 (6): 3254–3258. doi:10.1073/pnas.77.6.3254. ISSN 0027-8424.
- ↑ 9.0 9.1 Wang, K. (1995), "Titin and Nebulin: Giant Multitasking Protein Rulers in Muscle", The Cytoskeleton, Berlin, Heidelberg: Springer Berlin Heidelberg, pp. 93–106, ISBN 978-3-642-79484-1, retrieved 2021-12-25
- ↑ NIH Record, vol. 61, no. 10; May 15, 2009
- ↑ "Wang Kuan". Taipei Medical University. Retrieved 2022-01-16.
External links
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