Christoph W Müller
Christoph W Müller | |
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| Alma mater | University of Freiburg (PhD) |
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| Institutions | European Molecular Biology Laboratory |
| Website | https://www.embl.org/groups/mueller/ |
Christoph W Müller (born 2nd April 1960) is a German structural biologist. He is the Head of the Structural and Computational Biology Unit[1] [2] at the European Molecular Biology Laboratory in Heidelberg, Germany.
Education
Müller studied chemistry at the University of Freiburg from 1981 to 1986. He received his PhD in x-ray crystallography and biochemistry in 1991 from the University of Freiburg.
Career and Research
Müller held postdoctoral fellowships at the University of Freiburg, and Harvard University. He was appointed Group leader in structural biology at EMBL Grenoble in 1995 and Deputy Head of EMBL Grenoble in 2000. Müller has been the Head of the Structural and Computational Biology Unit at EMBL Heidelberg since 2007. Müller’s research uses Cryogenic electron microscopy|cryo-electron microscopy, x-ray crystallography, biophysical and biochemical approaches to learn about the molecular mechanisms of transcription regulation in Eukaryote|eukaryotes where DNA is packaged into chromatin. His areas of research comprise DNA recognition by eukaryotic transcription factors[3], molecular mechanisms of nuclear transport[4], and the structural basis of DNA-dependent RNA transcription initiation, elongation and termination by RNA polymerase I and III.[5]
- ↑ "Christoph Müller, Head of Structural and Computational Biology Unit | People | EMBL". embl.org.
- ↑ "Structural and Computational Biology". embl.org.
- ↑ Becker, Stefan; Groner, Bernd; Müller, Christoph W. (July 1998). "Three-dimensional structure of the Stat3β homodimer bound to DNA". Nature. 394 (6689): 145–151. doi:10.1038/28101.
- ↑ Cingolani, Gino; Petosa, Carlo; Weis, Karsten; Müller, Christoph W. (May 1999). "Structure of importin-β bound to the IBB domain of importin-α". Nature. 399 (6733): 221–229. doi:10.1038/20367.
- ↑ Girbig, Mathias; Misiaszek, Agata D.; Müller, Christoph W. (September 2022). "Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases". Nature Reviews Molecular Cell Biology. 23 (9): 603–622. doi:10.1038/s41580-022-00476-9.